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1.发明授权Methods of identifying compounds that inhibit DNA synthesis in mycobacterium tuberculosis and compositions, reagents and kits for performing the same 失效识别在结核分枝杆菌中抑制DNA合成的化合物的方法及其组合物，试剂和用于进行结核分枝杆菌的试剂盒的方法
公开(公告)号：US5834279A
公开(公告)日：1998-11-10
申请号：US813940
申请日：1997-03-03
申请人： Harvey Rubin , Fude Yang , David Avarbock , Sean Curran
发明人： Harvey Rubin , Fude Yang , David Avarbock , Sean Curran
CPC分类号： C12N9/0093 , C12N9/90 , C12Y117/04001 , C12Y599/01002 , A01K2217/05
摘要： Nucleic acid molecules that encode R2 subunit protein and topoisomerase I protein, fragments thereof, recombinant expression vectors and host cells are disclosed. Oligonucleotide molecules with nucleotide sequences complimentary to a nucleotide sequence encode R2 subunit protein and topoisomerase I protein are disclosed.
摘要翻译： 公开了编码R2亚基蛋白和拓扑异构酶I蛋白的核酸分子，其片段，重组表达载体和宿主细胞。 公开了具有与编码R2亚单位蛋白质和拓扑异构酶I蛋白质的核苷酸序列互补的核苷酸序列的寡核苷酸分子。
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公开(公告)号：US09648488B2
公开(公告)日：2017-05-09
申请号：US12289298
申请日：2008-10-24
CPC分类号： H04W8/02 , H04L63/0892 , H04W12/06 , H04W76/12
摘要： Example embodiments and methods are directed to providing and otherwise handling user information within telecommunications networks, including wireless telecommunications networks. Example embodiments may include wireless networks having a Correlation Data Records Store (CDRS) that may store and update all user data needed by applications and services operating in example networks. Example methods may provide for collection and handling in the CDRS of all user information relied upon by applications and services operating in wireless networks, so as to reduce resource consumption by such applications and services.
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公开(公告)号：US09107032B2
公开(公告)日：2015-08-11
申请号：US12545607
申请日：2009-08-21
摘要： The present invention provides a method for implementation in a wireless communication system including a plurality of base stations, a plurality of gateways, and a plurality of mobility management entities. The method includes receiving, at a first mobility management entity and from a first base station, measurement data collected by the first base station for a first mobile unit having a connection to the wireless communication system via the first base station. The measurement data includes a temporary identifier associated with the first mobile unit for the duration of the connection. The method also includes identifying the first mobile unit using the temporary identifier and forming a first record associated with the first mobile unit. The first record includes the measurement data collected by the first base station for the first mobile unit and previously collected measurement data for the first mobile unit.
摘要翻译： 本发明提供一种在包括多个基站，多个网关和多个移动性管理实体的无线通信系统中实现的方法。 该方法包括在第一移动性管理实体和第一基站处接收由第一基站收集的用于具有经由第一基站与无线通信系统的连接的第一移动单元的测量数据。 测量数据包括在连接期间与第一移动单元相关联的临时标识符。 该方法还包括使用临时标识符识别第一移动单元并形成与第一移动单元相关联的第一记录。 第一记录包括由第一移动单元的第一基站收集的测量数据和第一移动单元的先前收集的测量数据。
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公开(公告)号：US20110044283A1
公开(公告)日：2011-02-24
申请号：US12545607
申请日：2009-08-21
摘要： The present invention provides a method for implementation in a wireless communication system including a plurality of base stations, a plurality of gateways, and a plurality of mobility management entities. The method includes receiving, at a first mobility management entity and from a first base station, measurement data collected by the first base station for a first mobile unit having a connection to the wireless communication system via the first base station. The measurement data includes a temporary identifier associated with the first mobile unit for the duration of the connection. The method also includes identifying the first mobile unit using the temporary identifier and forming a first record associated with the first mobile unit. The first record includes the measurement data collected by the first base station for the first mobile unit and previously collected measurement data for the first mobile unit.
摘要翻译： 本发明提供一种在包括多个基站，多个网关和多个移动性管理实体的无线通信系统中实现的方法。 该方法包括在第一移动性管理实体和第一基站处接收由第一基站收集的用于具有经由第一基站与无线通信系统的连接的第一移动单元的测量数据。 测量数据包括在连接期间与第一移动单元相关联的临时标识符。 该方法还包括使用临时标识符识别第一移动单元并形成与第一移动单元相关联的第一记录。 第一记录包括由第一移动单元的第一基站收集的测量数据和第一移动单元的先前收集的测量数据。
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公开(公告)号：US06490297B1
公开(公告)日：2002-12-03
申请号：US09325968
申请日：1999-06-04
IPC分类号： H04J312
摘要： The system and method of the invention enable any channel of a multi-channel communication link to be used for transmission of a control signal to a system component by a system controller. The system component, connected to the system controller by the multi-channel communication link, automatically locates the one or more signaling channels carrying the control signal(s) and then establishes communication with the system controller in accordance with the control signal(s). If no signaling channels are located after a predetermined number of attempts or after a predetermined period of time, the system component may, if particular conditions are met, reset itself before continuing to search for the signaling channel(s).
摘要翻译： 本发明的系统和方法使得多信道通信链路的任何信道能够用于由系统控制器将控制信号发送到系统组件。 通过多信道通信链路连接到系统控制器的系统组件自动定位携带控制信号的一个或多个信令信道，然后根据控制信号建立与系统控制器的通信。 如果在预定次数的尝试之后或在预定时间段之后没有信令信道被定位，则如果特定条件被满足，则系统组件可以在继续搜索信令信道之前重置自身。
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6.发明授权Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies 失效检测导致蛋白酶抑制剂不足的遗传突变的方法
公开(公告)号：US5827662A
公开(公告)日：1998-10-27
申请号：US722268
申请日：1996-12-18
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A method of producing a recombinant serine protease inhibitor capable of effectively modulating serine protease activity is provided. Compositions capable of modulating serine protease activity and use of such compositions to regulate inflammatory processes in cells are also provided.
摘要翻译： 提供了能够有效调节丝氨酸蛋白酶活性的重组丝氨酸蛋白酶抑制剂的制备方法。 还提供能够调节丝氨酸蛋白酶活性的组合物和这种组合物用于调节细胞中的炎症过程的组合物。
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公开(公告)号：US5266465A
公开(公告)日：1993-11-30
申请号：US735322
申请日：1991-07-24
申请人： Harvey Rubin , Zhi M. Wang , Barry S. Cooperman , Norman Schecter
发明人： Harvey Rubin , Zhi M. Wang , Barry S. Cooperman , Norman Schecter
CPC分类号： C07K14/8125 , A61K38/00
摘要： The invention provides .alpha.-1-antichymotrypsin and protein preparations comprising human .alpha.-1-antichymotrypsin produced by E. coli cells transformed with a DNA sequence encoding human .alpha.-1-antichymotrypsin. The invention also provides methods for producing .alpha.-1-antichymotrypsin. The invention further provides analogues of .alpha.-1-antichymotrypsin that exhibit antichymotrypsin, anti-trypsin and anti-thrombin activity and methods of producing the analogues.
摘要翻译： 本发明提供了包含用编码人α1-抗胰凝乳蛋白酶的DNA序列转化的大肠杆菌细胞产生的人α1-抗胰凝乳蛋白酶的α-1抗胰凝乳蛋白酶和蛋白质制剂。 本发明还提供了生产α-1抗胰凝乳蛋白酶的方法。 本发明还提供表现出抗胰凝乳蛋白酶，抗胰蛋白酶和抗凝血酶活性的α-1-抗胰凝乳蛋白酶的类似物和产生类似物的方法。
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8.发明授权
公开(公告)号：US5163045A
公开(公告)日：1992-11-10
申请号：US591182
申请日：1990-10-01
申请人： Bruce E. Caram , Ronald C. Roposh , Harvey Rubin
发明人： Bruce E. Caram , Ronald C. Roposh , Harvey Rubin
CPC分类号： H04L29/00
摘要： A communications system that is arranged to transport so-called connection oriented messages via respective virtual circuit connections is enhanced so that it also transports so-called connectionless messages via a predefined virtual circuit connection that is common among those data modules which participate in the connectionless message service. In particular, each module which participates in the connectionless message service is assigned, in addition to a primary address that is used in conjunction with associated channels numbers to transport respective connection oriented messages, a common address and a channel number that is used solely for transporting connectionless messages. In this way, the communications system processes connectionless messages as though they were connection oriented messages.
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公开(公告)号：US4562436A
公开(公告)日：1985-12-31
申请号：US399186
申请日：1982-07-16
申请人： Charles L. Coleman , Harvey Rubin
发明人： Charles L. Coleman , Harvey Rubin
CPC分类号： H04M3/30
摘要： A mechanized system distributing the access, test and communication functions to the pont of testing, typically the centralized switching facility serving the telephone loops and equipment to be tested. Computer (200) stores information about each subscriber loop in the geographical area served by a system. Front-end computers (220,221) interact with computer (200) to retrieve pertinent data regarding loops to be tested. Each switching facility in an area includes a loop testing system (e.g., 160) that implements the required functions. The communication functions residing in front-end computers (220,221) and loop testing systems (160,161) are coupled via a data communication network (140) in a manner that allows any front-end computer to communicate with any loop testing system. Users of the system control access and test from consoles having the capability of establishing independent communication paths over the national dial network for interactive tests in loops accessed through standard test trunks. Microprocessor-based circuitry is utilized for numerous system tasks such as signal generation, digital signal processing and controlling sensitive analog measurements. Signal generation includes digital generation of analog waveforms. Signal processing techniques incorporate various digital filters to analyze sample sequences derived from, for example, dial pulses and coin telephone signals. Sensitive analog measurements of loop characteristics are effected with a magnetic current detector that operates over broad current and frequency ranges. Frequency dependent measurements are converted to DC using synchronous demodulation techniques to enhance resolution.
摘要翻译： 将访问，测试和通信功能分配给测试的机械化系统，通常是服务于要测试的电话回路和设备的集中式交换设施。 计算机（200）存储关于由系统服务的地理区域中的每个用户环路的信息。 前端计算机（220,221）与计算机（200）进行交互以检索关于要测试的循环的相关数据。 区域中的每个切换设备包括实现所需功能的环路测试系统（例如，160）。 驻留在前端计算机（220,221）和环路测试系统（160,161）中的通信功能通过数据通信网络（140）以允许任何前端计算机与任何环路测试系统通信的方式耦合。 系统的用户通过控制台进行访问和测试，具有通过国家拨号网络建立独立通信路径的功能，用于通过标准测试中继线访问的循环中的交互式测试。 基于微处理器的电路用于许多系统任务，例如信号生成，数字信号处理和控制敏感的模拟测量。 信号发生包括模拟波形的数字生成。 信号处理技术包括各种数字滤波器以分析从例如拨号脉冲和硬币电话信号导出的样本序列。 使用在宽电流和频率范围内工作的磁流检测器实现环路特性的敏感模拟测量。 使用同步解调技术将频率相关测量值转换为直流，以增强分辨率。
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10.发明授权Methods for providing a reliable server architecture using a multicast topology in a communications network 有权在通信网络中使用组播拓扑提供可靠的服务器架构的方法公开(公告)号：US07307945B2
公开(公告)日：2007-12-11
申请号：US10306511
申请日：2002-11-27
申请人： Mitchell R Gerdisch , Harvey Rubin
发明人： Mitchell R Gerdisch , Harvey Rubin
CPC分类号： H04L12/1886 , H04L12/1836 , H04L12/185
摘要： Multi cast techniques are employed to provide host computer elements access to multiple redundant servers of a communication network in such a way that the hosts need not know which of the servers is active. In one embodiment, the servers provide a gateway function between an Ethernet LAN and an external network. The Ethernet LAN comprises one or more hosts connected to one or more switches, the switches connected to corresponding servers defining an active/standby pair. The servers are connected to an external network by corresponding active/standby links. The hosts send messages directed to a multicast address to at least one of the switches. The switches forward the messages on ports according to a multicast routing topology having been determined by performing IGMP “snooping” of messages issued from the servers. Both the active and standby servers receive the messages; and the active server sends the messages to the external network. In case the active server fails or is removed from service, the standby server is promoted to active server and assumes the role of the formerly active server without necessitating any communication to the hosts to inform them of the change in status of the active server.
摘要翻译： 使用多播技术来提供主机计算机元件访问通信网络的多个冗余服务器，使得主机不需要知道哪个服务器是活动的。 在一个实施例中，服务器在以太网LAN和外部网络之间提供网关功能。 以太网LAN包括连接到一个或多个交换机的一个或多个主机，交换机连接到定义主备对的相应服务器。 服务器通过相应的主备链路连接到外部网络。 主机向至少一个交换机发送定向到组播地址的消息。 根据通过对从服务器发出的消息执行IGMP“窥探”确定的组播路由拓扑，交换机转发端口上的消息。 主服务器和备用服务器都接收消息; 活动服务器将消息发送到外部网络。 如果活动服务器发生故障或从服务中删除，则备用服务器将升级为活动服务器，并承担以前活动的服务器的角色，而不需要与主机进行任何通信，以通知他们活动服务器状态的更改。
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