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公开(公告)号：US20180246133A1
公开(公告)日：2018-08-30
申请号：US15756431
申请日：2016-07-01
Inventor： Kenta IMAI , Toshiharu SUZUKI , Shigeki MATSUBARA , Takayuki SUGIME , Shunsuke SASAKI , Elke FAATZ , Beatus OFENLOCH-HAEHNLE
CPC classification number: G01N35/1002 , G01N35/00663 , G01N35/00693 , G01N35/1011 , G01N2035/00673
Abstract: In conventional automatic analyzers, there have been instances where, when a plurality of associated items are analyzed as a set item, there is high variation in the analysis data obtained using the set item, leading to a need for improvement of analysis precision. The present invention comprises performing, in mutual association, a set of preparation steps to carry out until it is time to analyze an unknown sample, the set of preparation steps including a pre-preparation step in which stirring, etc., is performed when an analysis reagent kit is mounted on the analyzer, and a step for correcting a standard curve in which correction samples that correspond to analysis items are used. This makes it possible to perform analysis after the preparation states of a plurality of analysis reagent kits are collected as needed, enabling high-precision analysis of a set item.
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公开(公告)号：US20210018522A1
公开(公告)日：2021-01-21
申请号：US16637808
申请日：2018-07-26
Applicant: Hitachi High-Technologies Corporation
Inventor： Yoshihiro YAMASHITA , Takenori OKUSA , Shunsuke SASAKI
IPC: G01N35/00 , G01N35/02 , G01N33/543
Abstract: An object is to provide an automatic analyzer that prevents an effect of various environmental changes on an equilibrium state of an immunological binding reaction. An automatic analyzer of an embodiment of the invention includes a B/F separation unit that executes a B/F separation step separating an unreacted component and a reacted component from a liquid in which a sample and a reagent are reacted, a detection unit that detects a reacted component in the liquid after the B/F separation step, and a temperature maintaining unit that maintains the B/F separation unit and the detection unit in substantially the same temperature environment.
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公开(公告)号：US20180224474A1
公开(公告)日：2018-08-09
申请号：US15750526
申请日：2016-07-25
Applicant: Hitachi High-Technologies Corporation
Inventor： Shunsuke SASAKI , Kenta IMAI , Toshiharu SUZUKI , Katsuhiko SAKAMOTO
IPC: G01N35/00
CPC classification number: G01N35/00584 , G01N35/00 , G01N2035/00346
Abstract: The purpose of the present invention is to attain an automated analyzer that keeps the costs required for inspection to a minimum and is capable of starting measurement immediately after being turned on. As a solution, provided is an automated analyzer provided with an analysis operation part that causes a sample and a reagent to react and on the basis of the reaction result performs analysis of the sample, wherein: the automated analyzer comprises a plurality of units constituting the analysis operation part, a temperature adjustment mechanism that heats or cools the units, a temperature sensor that measures the temperature of the units, and a control part that controls the temperature adjustment mechanism; and the control part sets the measurement startable temperature range of each unit, which is the temperature range of the operation specification thereof, and the operable temperature range, which is a temperature range that is wider than the measurement startable temperature range, and starts the analysis process of the sample when the temperature of the unit has entered the operable temperature range of the unit.
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公开(公告)号：US20170205321A1
公开(公告)日：2017-07-20
申请号：US15320769
申请日：2015-06-15
Applicant: Hitachi High-Technologies Corporation
Inventor： Shunsuke SASAKI , Yoshihiro YAMASHITA
Abstract: In a liquid stirring method, after a second liquid is discharged into a reaction container accommodating a first liquid from a dispensing probe provided with a dispensing tip at the leading end thereof, a mixture of the first liquid and second liquid in the container is stirred by being sucked out and discharged by the dispensing probe. The number of stirrings through sucking out and discharging is changed according to the total volume of the first liquid and second liquid. If the total volume of the first liquid and second liquid is below a preset threshold, sucking out and discharging is repeated for a prescribed number of times.
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公开(公告)号：US20200278367A1
公开(公告)日：2020-09-03
申请号：US16647109
申请日：2018-11-15
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Kenta IMAI , Shunsuke SASAKI , Hiroya UMEKI , Tatsuki TAKAKURA , Takenori OKUSA , Hiroki FUJITA , Taku SAKAZUME
Abstract: To provide an automated analyzer capable of shortening analysis time. The automated analyzer includes a vessel which contains a mixed solution of a specimen and a reagent; and a control unit which controls a first operation performed on the vessel, a second operation performed on the vessel after the first operation, and a third operation performed on a predetermined mechanism of the automated analyzer before the second operation, in which the control unit performs the first operation and the third operation in parallel. Alternatively, the automated analyzer includes a control unit which controls a first operation performed on the vessel, a second operation performed on the vessel after the first operation, and a third operation performed on a predetermined mechanism of the automated analyzer after the first operation, in which the control unit performs the second operation and the third operation in parallel.
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Patent Agency Ranking
公开(公告)号：US20200241022A1
公开(公告)日：2020-07-30
申请号：US16482979
申请日：2018-01-18
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Takenori OKUSA , Yoshihiro YAMASHITA , Shunsuke SASAKI
IPC: G01N35/00
Abstract: It is necessary to dispose a plurality of units which have different target temperatures on an apparatus in a more integrated state in order to improve analysis performance and processing capacity per unit space of the apparatus. Therefore, it is necessary to mitigate influence of temperature exerted between units.It is possible to reduce the temperature influence exerted between the units and thus efficiently control temperature by properly disposing the units in the apparatus, based on the relationship between a use environment temperature of the apparatus and a target temperature of each unit and temperature accuracy required for the unit.
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公开(公告)号：US20200164377A1
公开(公告)日：2020-05-28
申请号：US16633067
申请日：2018-06-29
Applicant: Hitachi High-Technologies Corporation
Inventor： Shunsuke SASAKI , Takenori OKUSA
Abstract: An automatic analysis device which can be accessed from a front surface of the device to a rear surface side of the device when a user accesses the automatic analysis device and reduce the risk of damage to rod-shaped member due to contact. A reagent suction position, a reagent discharge position, a reagent dispensing nozzle cleaning portion, and a reagent dispensing mechanism retraction portion from which the reagent dispensing mechanism is retracted are disposed on a trajectory of an arm of the reagent dispensing mechanism. A nozzle guide accommodation portion accommodates a nozzle guide of a reagent dispensing mechanism and the reagent dispensing nozzle. The reagent dispensing mechanism retraction portion is a cylindrical member protruding downward from an upper surface cover of the automatic analysis device and prevent direct contact with the reagent dispensing nozzle by positioning the reagent dispensing nozzle in the nozzle accommodation portion.
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公开(公告)号：US20190351419A1
公开(公告)日：2019-11-21
申请号：US16477535
申请日：2018-02-15
Applicant: Hitachi High-Technologies Corporation
Inventor： Hiroki FUJITA , Toshiharu SUZUKI , Takenori OKUSA , Shunsuke SASAKI , Yoshihiro YAMASHITA , Kenta IMAI
Abstract: The mixing of reagents with each other in the reagent storage flow paths of an automatic analyzer is suppressed before and after exchange of the reagents, which are capable of being replenished without stopping analysis. An exchangeable reagent container that accommodates a reagent is connected to a reagent storage flow path that stores a portion of the reagent. The reagent storage flow path has first and second flow paths in which the second flow path is branched from the first flow path. A reagent syringe applies a negative or a positive pressure to the first and second flow paths; and a valve controls the flow path through which the reagent is sent. As a result, the reagent supplied to a measurement portion at a predetermined timing is switched from the reagent container to the reagent storage flow path wherein the reagent can be supplied without stopping analysis.
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公开(公告)号：US20200249249A1
公开(公告)日：2020-08-06
申请号：US16477221
申请日：2018-02-15
Applicant: Hitachi High-Technologies Corporation
Inventor： Hiroya UMEKI , Kenta IMAI , Yoshihiro YAMASHITA , Shunsuke SASAKI , Akihiro ENDOU
Abstract: An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.
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公开(公告)号：US20200241029A1
公开(公告)日：2020-07-30
申请号：US16641349
申请日：2018-06-21
Applicant: Hitachi High-Technologies Corporation
Inventor： Kenta IMAI , Hiroya UMEKI , Shunsuke SASAKI , Yoshihiro YAMASHITA , Taku SAKAZUME
IPC: G01N35/10 , G01N33/49 , G01N33/493 , G01N35/04
Abstract: There is provided an automatic analysis device that can easily realize introduction and replacement of additional reagents in operation even in a small-scale configuration. The automatic analysis device includes a reagent dispensing mechanism 107 that dispenses a reagent from a reagent container 113 containing a reagent, and a normal reagent storage portion 130 that stores a reagent container and an additional reagent storage portion 111. The normal reagent storage portion 130 is positioned in a normal movable area 132, which is a portion of a movable area 131 of the reagent dispensing mechanism 107 and the additional reagent storage portion 111 is positioned in an area excluding the normal movable area 132 in the movable area 131 of the reagent dispensing mechanism 107. The reagent dispensing mechanism 107 performs an access operation in the normal movable area 132 in the normal operation and performs an access operation to the additional reagent storage portion 111 upon receiving a predetermined instruction.
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