公开(公告)号：US11186557B2

公开(公告)日：2021-11-30

申请号：US15763926

申请日：2016-08-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Akinori Oda ,  Hiroshi Satozono ,  Tomomi Shinke ,  Yohei Takata

IPC: G01N33/52 ,  G01N21/64 ,  C07D277/66 ,  G01N33/68

Abstract: The present invention relates to a method for purifying pure thioflavin T in having a step of preparing a thioflavin T solution in which crude thioflavin T is dissolved in a polar solvent, a step of bringing the thioflavin T solution into contact with a non-polar polymeric porous body, and a step of separating the thioflavin T solution after the contact from the non-polar polymeric porous body.

公开(公告)号：US11730540B2

公开(公告)日：2023-08-22

申请号：US16613197

申请日：2018-05-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yohei Takata ,  Yoshiyuki Shimizu ,  Tsuyoshi Kosugi ,  Hiroyuki Okada

IPC: A61B18/24 ,  A61M25/00

CPC classification number: A61B18/24 ,  A61M25/0082

Abstract: A catheter kit includes a catheter having an optical fiber, and a catheter accommodating tool which accommodates the catheter. The catheter accommodating tool has a tubular hoop, and a position adjustment mechanism provided at the hoop. The hoop has a hoop tip end portion at which a catheter tip end portion, from which laser light transmitted through the optical fiber is emitted, is disposed, and a hoop base end portion which is opposite to the hoop tip end portion. The position adjustment mechanism is provided at the hoop base end portion and changes a position of the catheter tip end portion with respect to the hoop tip end portion.

公开(公告)号：US11653837B2

公开(公告)日：2023-05-23

申请号：US16314877

申请日：2017-06-27

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Hiroyuki Okada ,  Tsuyoshi Kosugi ,  Yoshiyuki Shimizu ,  Yohei Takata

IPC: A61B5/00 ,  A61B18/24 ,  G02B6/42

CPC classification number: A61B5/0084 ,  A61B18/24 ,  G02B6/42

Abstract: A light output monitoring apparatus includes a light receiving unit, an attachment unit, an adapter, and a protective cap, and monitors a power of light output from a light emitting end of a catheter incorporating an optical fiber. The protective cap includes an insertion opening into which a part of the catheter of a predetermined range on the light emitting end side is removably inserted, includes a window portion for transmitting the light output from the light emitting end of the catheter, and is fixed in position by being inserted into a through-hole of the adapter. The adapter is fixed in position by being attached to the attachment unit.

公开(公告)号：US20220357276A1

公开(公告)日：2022-11-10

申请号：US17858183

申请日：2022-07-06

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Akinori ODA ,  Hiroshi Satozono ,  Tomomi Shinke ,  Yohei Takata

IPC: G01N21/64 ,  G01N33/68

Abstract: The present invention relates to a method for detecting an amyloid β oligomer which includes a test sample and thioflavin T are brought into contact with each other, fluorescence of the thioflavin T is measured to obtain time-resolved fluorescence spectra, the time-resolved fluorescence spectrum of time period t1 to t2 and the time-resolved fluorescence spectrum of time period t3 to t4 are respectively normalized to obtain normalized spectra (t1