公开(公告)号：US20220357276A1

公开(公告)日：2022-11-10

申请号：US17858183

申请日：2022-07-06

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Akinori ODA ,  Hiroshi Satozono ,  Tomomi Shinke ,  Yohei Takata

IPC: G01N21/64 ,  G01N33/68

Abstract: The present invention relates to a method for detecting an amyloid β oligomer which includes a test sample and thioflavin T are brought into contact with each other, fluorescence of the thioflavin T is measured to obtain time-resolved fluorescence spectra, the time-resolved fluorescence spectrum of time period t1 to t2 and the time-resolved fluorescence spectrum of time period t3 to t4 are respectively normalized to obtain normalized spectra (t1

公开(公告)号：US11186557B2

公开(公告)日：2021-11-30

申请号：US15763926

申请日：2016-08-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Akinori Oda ,  Hiroshi Satozono ,  Tomomi Shinke ,  Yohei Takata

IPC: G01N33/52 ,  G01N21/64 ,  C07D277/66 ,  G01N33/68

Abstract: The present invention relates to a method for purifying pure thioflavin T in having a step of preparing a thioflavin T solution in which crude thioflavin T is dissolved in a polar solvent, a step of bringing the thioflavin T solution into contact with a non-polar polymeric porous body, and a step of separating the thioflavin T solution after the contact from the non-polar polymeric porous body.