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公开(公告)号:US20250016476A1
公开(公告)日:2025-01-09
申请号:US18709973
申请日:2022-11-10
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Takafumi HIGUCHI , Katsuhiro NAKAMOTO , Teruo TAKAHASHI , Mao NAKAJIMA
IPC: H04N25/773 , G01J1/44 , H04N25/618
Abstract: A threshold value determination method includes a step of calculating a probability distribution of a provisional value for each photon number of a target pixel based on an observation probability for each photoelectron number based on a probability distribution of the photon number and an observation probability for each photoelectron number based on a probability distribution of the photoelectron number accompanying reading noise of the target pixel and a step of calculating threshold value data for sorting the provisional value into a corresponding photon number based on the probability distribution for each photon number.
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2.
公开(公告)号:US20240344985A1
公开(公告)日:2024-10-17
申请号:US18293518
申请日:2022-07-25
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Takafumi HIGUCHI , Kenichiro IKEMURA
CPC classification number: G01N21/6456 , G01N21/6428 , G06T7/0002 , G01N2021/6439 , G06T2207/10064
Abstract: A dye image acquisition system includes an image acquisition device that irradiates a sample with each of excitation light beams having C wavelength distributions and acquires the C fluorescence images each including N pixels; and an image processing device that clusters the N pixels into L (L is an integer of 2 or more and N−1 or less) pixel groups based on fluorescence intensities of respective pixels of the C fluorescence images, generates L cluster matrices in which the C fluorescence images are arranged, calculates statistical values of the fluorescence intensities of the pixel groups configuring the C fluorescence images, and performs unmixing on the C fluorescence images by using the statistical values of the C fluorescence images, and generates K (K is an integer of 2 or more and C or less) dye images indicating a distribution for each K dyes.
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公开(公告)号:US20250016475A1
公开(公告)日:2025-01-09
申请号:US18709905
申请日:2022-11-10
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Takafumi HIGUCHI , Teruo TAKAHASHI , Mao NAKAJIMA , Katsuhiro NAKAMOTO
IPC: H04N25/773 , H04N25/616 , H04N25/778
Abstract: A photon number resolving system includes: a plurality of pixels of which each includes a photoelectric conversion element and an amplifier for amplifying the electric charges converted by the photoelectric conversion element and converting the electric charges to a voltage; an A/D converter configured to convert a voltage output from the amplifier of each of the plurality of pixels to a digital value; a first deriving unit configured to derive a provisional value of a photon number in each pixel of the plurality of pixels based on the digital value; and a second deriving unit configured to derive a confirmed value of a photon number in a target pixel based on a first probability based on optical shot noise and a second probability based on reading noise.
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4.
公开(公告)号:US20240314470A1
公开(公告)日:2024-09-19
申请号:US18275443
申请日:2021-12-24
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Takafumi HIGUCHI , Teruo TAKAHASHI , Mao NAKAJIMA , Katsuhiro NAKAMOTO
IPC: H04N25/773 , G01J1/44 , H04N25/618
CPC classification number: H04N25/773 , G01J1/44 , H04N25/618 , G01J2001/442
Abstract: A photon counting device includes: a plurality of pixels each including a photoelectric conversion element and an amplifier amplifying charge to which input light is converted by the photoelectric conversion element and converting the amplified charge to a voltage; an A/D converter converting a voltage output from the amplifier of each of the plurality of pixels to a digital value; a first derivation unit configured to derive a provisional value of photon number in each of the plurality of pixels based on the digital value; and a second derivation unit configured to derive a confirmed value of photon number in a target pixel based on a first probability associated with a photon number distribution and a second probability associated with reading noise.
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公开(公告)号:US20230251392A1
公开(公告)日:2023-08-10
申请号:US18133578
申请日:2023-04-12
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Tadashi MARUNO , Eiji TODA , Mao NAKAJIMA , Teruo TAKAHASHI , Takafumi HIGUCHI
IPC: G01T1/24 , H04N25/65 , H04N25/74 , H04N25/75 , H04N25/767 , H04N25/772 , H04N25/778
CPC classification number: G01T1/247 , H04N25/65 , H04N25/74 , H04N25/75 , H04N25/767 , H04N25/772 , H04N25/778 , G01T1/208
Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltages output from the amplifiers of the plurality of pixels to digital values; and a conversion unit configured to convert the digital value output from the A/D converter to the number of photons by referring to reference data, for each of the plurality of pixels, and the reference data is created based on a gain and an offset value for each of the plurality of pixels.
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公开(公告)号:US20220301135A1
公开(公告)日:2022-09-22
申请号:US17608857
申请日:2020-04-16
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Tomochika TAKESHIMA , Takafumi HIGUCHI , Kazuhiro HOTTA
Abstract: A semiconductor inspection method by an observation system includes a step of acquiring a first pattern image showing a pattern of a semiconductor device, a step of acquiring a second pattern image showing a pattern of the semiconductor device and having a different resolution from a resolution of the first pattern image, a step of learning a reconstruction process of the second pattern image using the first pattern image as training data by machine learning, and reconstructing the second pattern image into a reconstructed image having a different resolution from a resolution of the second pattern image by the reconstruction process based on a result of the learning, and a step of performing alignment based on a region calculated to have a high degree of certainty by the reconstruction process in the reconstructed image and the first pattern image.
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公开(公告)号:US20220301197A1
公开(公告)日:2022-09-22
申请号:US17608833
申请日:2020-04-16
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Tomochika TAKESHIMA , Takafumi HIGUCHI , Kazuhiro HOTTA
Abstract: An observation system includes a detector that detects light from a semiconductor device and outputs a detection signal, a 2D camera, an optical device that guides light to the detector and the 2D camera, an image processing unit that generates a first optical image of the semiconductor device based on the detection signal and receives an input of a first CAD image, an image analysis unit that learns a conversion process of the first CAD image by machine learning using the first optical image as training data, and converts the first CAD image into a second CAD image resembling the first optical image by the conversion process based on a result of the learning, and an alignment unit that performs alignment based on a second optical image and the second CAD image.
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8.
公开(公告)号:US20220221411A1
公开(公告)日:2022-07-14
申请号:US17604000
申请日:2020-04-09
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Tomochika TAKESHIMA , Takafumi HIGUCHI , Kazuhiro HOTTA
Abstract: A semiconductor apparatus examination method includes a step of acquiring a first interference waveform based on signals from a plurality of drive elements according to light from a first light beam spot including the plurality of drive elements in a semiconductor apparatus, a step of acquiring a second interference waveform based on signals from the plurality of drive elements according to light from a second light beam spot having a region configured to partially overlap the first spot and including the plurality of drive elements, and a step of separating a waveform signal for each of the drive elements in the first and second spots based on the first and second interference waveforms.
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公开(公告)号:US20220206063A1
公开(公告)日:2022-06-30
申请号:US17606829
申请日:2020-04-09
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Tomochika TAKESHIMA , Takafumi HIGUCHI , Kazuhiro HOTTA
IPC: G01R31/303
Abstract: A semiconductor device examination method includes a step of acquiring a first interference waveform based on signals from a plurality of drive elements according to light from a first light beam spot including the plurality of drive elements in a semiconductor device, a step of acquiring a second interference waveform based on signals from the plurality of drive elements according to light from a second light beam spot having a region configured to partially overlap the first spot and including the plurality of drive elements, and a step of separating a waveform signal for each of the drive elements in the first and second spots based on the first and second interference waveforms.
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公开(公告)号:US20220066055A1
公开(公告)日:2022-03-03
申请号:US17501398
申请日:2021-10-14
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor: Tadashi MARUNO , Eiji TODA , Mao NAKAJIMA , Teruo TAKAHASHI , Takafumi HIGUCHI
Abstract: A photon counting device includes a plurality of pixels each including a photoelectric conversion element configured to convert input light to charge, and an amplifier configured to amplify the charge converted by the photoelectric conversion element and convert the charge to a voltage, an A/D converter configured to convert the voltage output from the amplifier of each of the plurality of pixels to a digital value and output the digital value, a correction unit configured to correct the digital value output from the A/D converter so that an influence of a variation in a gain and an offset value among the plurality of pixels is curbed, a calculation unit configured to output a summed value obtained by summing the corrected digital values corresponding to at least two pixels, and a conversion unit configured to convert the summed value output from the calculation unit to a number of photons.
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