公开(公告)号：US20230245478A1

公开(公告)日：2023-08-03

申请号：US18010545

申请日：2021-06-11

Applicant: HAMAMATSU PHOTONICS K.K. ,  NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE

Inventor： Fumio HASHIMOTO ,  Kibo OTE ,  Hidenao YAMADA ,  Hirotoshi KIKUCHI ,  Amane HIROTSU ,  Shigetoshi OKAZAKI

IPC: G06V20/69 ,  G06V10/40

CPC classification number: G06V20/698 ,  G06V10/40 ,  G06V2201/03

Abstract: A discrimination device is a device that discriminates whether or not a discrimination target object is a blood cell based on an image of the discrimination target object, and includes a blood cell feature extraction unit that acquires an image of a blood cell and extracts a feature of the blood cell from the acquired image, a discrimination target object feature extraction unit that acquires the image of the discrimination target object and extracts a feature of the discrimination target object from the acquired image, and a discrimination unit that discriminates whether or not the discrimination target object is a blood cell through anomaly detection based on the extracted feature of the blood cell and the feature of the discrimination target object.

公开(公告)号：US20200300762A1

公开(公告)日：2020-09-24

申请号：US16089394

申请日：2017-03-08

Applicant: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE ,  HAMAMATSU PHOTONICS K.K.

Inventor： Naoya MATSUMOTO ,  Shigetoshi OKAZAKI

IPC: G01N21/64 ,  G02B21/00 ,  G02B21/36 ,  G02B21/02

Abstract: An image acquisition apparatus includes a spatial light modulator, an optical scanner, a detection unit, a control unit. The spatial light modulator performs focused irradiation on irradiation regions on a surface or inside of an observation object with modulated excitation light. The detection unit has imaging regions in an imaging relation with the irradiation regions on a light receiving surface, each of the imaging regions corresponds to one or two or more pixels, and a pixel that corresponds to none of the imaging regions exists adjacent to each imaging region. The control unit corrects a detection signal of a pixel corresponding to each imaging region on the basis of a detection signal of the pixel that exists adjacent to the imaging region and corresponds to none of the imaging regions, and generates an image of the observation object on the basis of the corrected detection signal.

公开(公告)号：US20190070608A1

公开(公告)日：2019-03-07

申请号：US16122048

申请日：2018-09-05

Applicant: HAMAMATSU PHOTONICS K.K. ,  NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE

Inventor： Hirotoshi KIKUCHI ,  Shigetoshi OKAZAKI ,  Hidenao YAMADA ,  Yusuke OZAKI ,  Amane HIROTSU ,  Daisuke YAMASHITA

IPC: B01L3/00 ,  G01N15/14

Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first observation apparatus, a second observation apparatus, and a control device. The first observation apparatus includes an objective lens and a line camera. The second observation apparatus includes an objective lens and an area camera. The control device analyzes first imaging data output from the first observation apparatus to determine whether the cell satisfies a specific condition, instructs the area camera to output second imaging data of the cell determined to satisfy the specific condition, and analyzes the second imaging data output from the second observation apparatus to determine whether the cell is a specific cell.

公开(公告)号：US20240319202A1

公开(公告)日：2024-09-26

申请号：US18591189

申请日：2024-02-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Gen TAKEBE ,  Shigetoshi OKAZAKI

IPC: G01N33/68 ,  C09B11/06 ,  C09K11/06 ,  G01N21/31 ,  G01N21/64

CPC classification number: G01N33/68 ,  C09B11/06 ,  C09K11/06 ,  G01N21/3103 ,  G01N21/6428 ,  C09K2211/1007 ,  C09K2211/1018 ,  G01N2021/6439

Abstract: A method for evaluating an aggregation state of aggregative proteins in a solution is disclosed, the method comprising evaluating an aggregation state of aggregative proteins using, as an index, light-absorption/fluorescence characteristic(s) of a certain xanthene dye in a solution comprising the aggregative proteins and the xanthene dye or a salt thereof.

公开(公告)号：US20220120660A1

公开(公告)日：2022-04-21

申请号：US17310813

申请日：2020-02-14

Applicant: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE ,  HAMAMATSU PHOTONICS K.K.

Inventor： Hirotoshi KIKUCHI ,  Hidenao YAMADA ,  Amane HIROTSU ,  Daisuke YAMASHITA ,  Shigetoshi OKAZAKI

IPC: G01N15/14 ,  G02B21/36

Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first imaging apparatus, a second imaging apparatus, and a control device. The first imaging apparatus includes a first optical system and a first imaging element, and captures an image of the cell at a first position in a moving direction. The second imaging apparatus includes a second optical system, in which a focus is adjusted based on a focus adjustment signal, and a second imaging element, and captures an image of the cell at a second position downstream of the first position. The control device obtains a passing position of the cell in a cross section of the flow path based on the image obtained by the first imaging element, generates the focus adjustment signal, and provides the signal to the second optical system.