公开(公告)号：US10428147B2

公开(公告)日：2019-10-01

申请号：US15207880

申请日：2016-07-12

Applicant: H. Lundbeck A/S

Inventor： Lars Christian Biilmann Rønn ,  Ibrahim John Malik ,  Søren Christensen ,  Jan Egebjerg ,  Jeffrey B. Stavenhagen ,  Arnout Gerritsen ,  Edward van den Brink ,  Paul Parren ,  Rob de Jong

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61P25/28

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

公开(公告)号：US20180016330A1

公开(公告)日：2018-01-18

申请号：US15645442

申请日：2017-07-10

Applicant: H. Lundbeck A/S

Inventor： Jan Torleif Pedersen ,  Kristian Kjærgaard ,  Lars Østergaard Pedersen ,  Abdur-Rasheed Asuni ,  Nina Helen Rosenqvist ,  Justus Claus Alfred Daechsel ,  Karsten Juhl ,  Lena Tagmose ,  Mauro Marigo ,  Thomas Jensen ,  Søren Christensen ,  Laurent David ,  Christiane Volbracht ,  Lone Helboe

IPC: C07K16/18 ,  A61K39/00

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

公开(公告)号：US20170022268A1

公开(公告)日：2017-01-26

申请号：US15288476

申请日：2016-10-07

Applicant: H. Lundbeck A/S

Inventor： Søren Christensen ,  Lone Helboe

IPC: C07K16/18 ,  A61K39/00 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K39/0007 ,  A61K2039/575 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: The present invention relates to antibodies specific for pyroglutamated Aβ, as well as their use in the treatment of Alzheimer's disease and as use in diagnostic methods or as diagnostic imaging ligands. Further, is provided pyroglutamated N-terminal fragments of murine or human Aβ to generate antibodies and for use in therapeutic purposes.

Abstract translation: 本发明涉及对焦谷氨酰胺化Aβ特异的抗体，以及它们在治疗阿尔茨海默氏病中的用途，以及用于诊断方法或诊断成像配体。 此外，提供鼠类或人Aβ的焦谷氨酰胺化N-末端片段以产生抗体并用于治疗目的。

公开(公告)号：US11548950B2

公开(公告)日：2023-01-10

申请号：US17097457

申请日：2020-11-13

Applicant: H. Lundbeck A/S

Inventor： Lars Christian Biilmann Rønn ,  Ibrahim John Malik ,  Jeffrey B. Stavenhagen ,  Søren Christensen ,  Jan Egebjerg ,  Arnout Gerritsen ,  Edward van den Brink ,  Paul Parren ,  Rob de Jong

IPC: C07K16/00 ,  A61K51/10 ,  C07K16/28 ,  A61P25/28 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful correcting a deficient level progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

公开(公告)号：US20210292414A1

公开(公告)日：2021-09-23

申请号：US17118934

申请日：2020-12-11

Applicant: H. Lundbeck A/S

Inventor： Lars Christian Biilmann Rønn ,  Ibrahim John Malik ,  Jeffrey B. Stavenhagen ,  Søren Christensen ,  Jan Egebjerg ,  Tina Stummann ,  Arnout Gerritsen ,  Edward van den Brink ,  Paul Parren ,  Esben Trabjerg ,  Kasper Dyrberg Rand

IPC: C07K16/28

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders such as Alzheimers disease (AD).

公开(公告)号：US10479835B2

公开(公告)日：2019-11-19

申请号：US15743549

申请日：2016-07-12

Applicant: H. Lundbeck A/S

Inventor： Lars Christian Biilmann Rønn ,  Ibrahim John Malik ,  Jeffrey B. Stavenhagen ,  Søren Christensen ,  Jan Egebjerg ,  Arnout Gerritsen ,  Edward Van Den Brink ,  Paul Parren ,  Rob De Jong

IPC: C07K16/00 ,  A61K51/10 ,  C07K16/28 ,  A61P25/28 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

公开(公告)号：US20180305455A1

公开(公告)日：2018-10-25

申请号：US15743549

申请日：2016-07-12

Applicant: H. Lundbeck A/S

Inventor： Lars Christian Biilmann Rønn ,  Ibrahim John Malik ,  Jeffrey b. Stavenhagen ,  Søren Christensen ,  Jan Egebjerg ,  Arnout Gerritsen ,  Edward Van Den Brink ,  Paul Parren ,  Rob De Jong

IPC: C07K16/28 ,  A61K39/395 ,  A61P25/28

Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

公开(公告)号：US11739140B2

公开(公告)日：2023-08-29

申请号：US17144355

申请日：2021-01-08

Applicant: H. Lundbeck A/S

Inventor： Jan Torleif Pedersen ,  Lars Østergaard Pedersen ,  Justus Claus Alfred Daechsel ,  Ayodeji Abdur-rasheed Asuni ,  Nina Helen Rosenqvist ,  Christiane Volbracht ,  Lone Helboe ,  Anders Brandt Elvang ,  Florence Sotty ,  Søren Christensen ,  Jeffrey B. Stavenhagen

IPC: C07K16/18 ,  A61K39/395 ,  G01N33/68 ,  A61K49/00 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/395 ,  A61K49/00 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.

公开(公告)号：US20220177557A1

公开(公告)日：2022-06-09

申请号：US17399205

申请日：2021-08-11

Applicant: H. Lundbeck A/S

Inventor： Jan Torleif Pedersen ,  Kristian Kjaergaard ,  Lars Østergaard Pedersen ,  Ayodeji Abdur-Rasheed Asuni ,  Nina Helen Rosenqvist ,  Justus Claus Alfred Daechsel ,  Karsten Juhl ,  Lena Tagmose ,  Mauro Marigo ,  Thomas Jensen ,  Søren Christensen ,  Laurent David ,  Christiane Volbracht ,  Lone Helboe

IPC: C07K16/18 ,  A61K39/395 ,  A61K49/00 ,  G01N33/68

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PH F) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

公开(公告)号：US11111290B2

公开(公告)日：2021-09-07

申请号：US16585207

申请日：2019-09-27

Applicant: H. Lundbeck A/S

Inventor： Jan Torleif Pedersen ,  Kristian Kjaergaard ,  Lars Østergaard Pedersen ,  Ayodeji Abdur-Rasheed Asuni ,  Nina Helen Rosenqvist ,  Justus Claus Alfred Daechsel ,  Karsten Juhl ,  Lena Tagmose ,  Mauro Marigo ,  Thomas Jensen ,  Søren Christensen ,  Laurent David ,  Christiane Volbracht ,  Lone Helboe

IPC: C07K16/18 ,  A61K39/395 ,  A61K49/00 ,  G01N33/68 ,  A61K39/00

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.