公开(公告)号：US20250025544A1

公开(公告)日：2025-01-23

申请号：US18404681

申请日：2024-01-04

Applicant: Gritstone bio, Inc.

Inventor： Wade Blair ,  Karin Jooss ,  Leonid Gitlin ,  Ciaran Daniel Scallan ,  Amy Rachel Rappaport ,  Gijsbert Grotenbreg

IPC: A61K39/00 ,  C12N15/86

Abstract: Disclosed herein are vectors that include antigen-encoding nucleic acid sequences and co-express immune modulators. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.

公开(公告)号：US20230128001A1

公开(公告)日：2023-04-27

申请号：US17817312

申请日：2022-08-03

Applicant: Gritstone bio, Inc.

Inventor： Roman Yelensky ,  James Xin Sun ,  Joshua Klein ,  Karin Jooss ,  Ciaran Daniel Scallan ,  Leonid Gitlin

IPC: A61K39/21 ,  A61P31/18 ,  C12N15/86

Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines against infectious diseases such as HIV.

公开(公告)号：US20240067985A1

公开(公告)日：2024-02-29

申请号：US18152699

申请日：2023-01-10

Applicant: Gritstone bio, Inc.

Inventor： Wade Blair ,  Brendan Bulik-Sullivan ,  Jennifer Busby ,  Adnan Derti ,  Leonid Gitlin ,  Karin Jooss ,  Ciaran Daniel Scallan ,  Roman Yelensky ,  Gijsbert Grotenbreg

IPC: C12N15/86 ,  A61K35/761 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/74 ,  C07K16/28 ,  C12N7/00

CPC classification number: C12N15/86 ,  A61K35/761 ,  A61K39/0011 ,  A61K39/39541 ,  A61P35/00 ,  C07K14/70539 ,  C07K16/2818 ,  C12N7/00 ,  A61K2039/505 ,  A61K2039/5256 ,  C12N2710/10034 ,  C12N2710/10043 ,  C12N2710/10071

Abstract: Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.

公开(公告)号：US11771747B2

公开(公告)日：2023-10-03

申请号：US17727610

申请日：2022-04-22

Applicant: Gritstone bio, Inc.

Inventor： Karin Jooss ,  Roman Yelensky ,  James Xin Sun ,  Amy Rachel Rappaport ,  Ciaran Daniel Scallan ,  Leonid Gitlin ,  Christine Denise Palmer ,  Monica Lane

IPC: A61K39/00 ,  A61K39/005 ,  C12N15/86 ,  A61P35/00

CPC classification number: A61K39/001111 ,  A61P35/00 ,  A61K2039/5256 ,  A61K2039/53

Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.

公开(公告)号：US20220090138A1

公开(公告)日：2022-03-24

申请号：US17538716

申请日：2021-11-30

Applicant: Gritstone bio, Inc.

Inventor： Karin Jooss ,  Ciaran Daniel Scallan ,  Leonid Gitlin

IPC: C12N15/86 ,  C07K14/74 ,  A61K39/395 ,  A61P37/04 ,  A61K39/00 ,  A61P35/00

Abstract: Disclosed herein are compositions that include modified adenoviruses. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines. Also disclosed herein are viral vectors using TET promoter system and methods of producing viruses having the same.

公开(公告)号：US20240238412A1

公开(公告)日：2024-07-18

申请号：US18622497

申请日：2024-03-29

Applicant: Gritstone bio, Inc.

Inventor： Leonid Gitlin ,  Karin Jooss ,  Sue-Jean Hong ,  Ciaran Daniel Scallan ,  Amy Rachel Rappaport ,  Christine Denise Palmer ,  Minh Duc Cao ,  Joshua Klein

IPC: A61K39/215 ,  A61K39/00 ,  A61P37/04 ,  C12N15/86

CPC classification number: A61K39/215 ,  A61P37/04 ,  C12N15/86 ,  A61K2039/5256 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/36143 ,  C12N2830/50

Abstract: Disclosed herein are vaccine compositions that include Pancorona receptor binding domain (RBD) encoding cassettes and/or MHC epitope-encoding cassettes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.

公开(公告)号：US20240024445A1

公开(公告)日：2024-01-25

申请号：US18045812

申请日：2022-10-11

Applicant: Gritstone bio, Inc.

Inventor： Wade Blair ,  Karin Jooss ,  Amy Rachel Rappaport ,  Ciaran Daniel Scallan ,  Leonid Gitlin

IPC: A61K39/00 ,  A61P31/12 ,  A61K39/12 ,  C07K14/47 ,  C07K14/74 ,  C12N15/86

CPC classification number: A61K39/001191 ,  A61P31/12 ,  A61K39/001188 ,  A61K39/12 ,  C07K14/4748 ,  C07K14/70539 ,  A61K2039/70 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2039/605 ,  C12N15/86

Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.

公开(公告)号：US20230303614A1

公开(公告)日：2023-09-28

申请号：US18048407

申请日：2022-10-20

Applicant: Gritstone bio, Inc.

Inventor： Karin Jooss ,  Amy Rachel Rappaport ,  Ciaran Daniel Scallan ,  Leonid Gitlin ,  Sue-Jean Hong ,  Arvin Akoopie

IPC: C07H21/02 ,  C07H21/00 ,  C07H1/04 ,  A61K47/54 ,  A61K39/12 ,  C12N15/86

CPC classification number: C07H21/02 ,  C07H21/00 ,  C07H1/04 ,  A61K47/549 ,  A61K39/12 ,  C12N15/86 ,  A61K2039/53

Abstract: The present disclosure includes, among other things, non-natural nucleotides useful as 5′ caps for RNA nucleotides. The present disclosure also includes, among other things, compositions and methods using delivery and vaccine RNA nucleotide compositions that include non-natural nucleotides as 5′ caps.

公开(公告)号：US20230047979A1

公开(公告)日：2023-02-16

申请号：US17838114

申请日：2022-06-10

Applicant: Gritstone bio, Inc.

Inventor： Karin Jooss ,  Amy Rachel Rappaport ,  Ciaran Daniel Scallan ,  Leonid Gitlin

IPC: A61K39/193 ,  A61K39/00

Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.

公开(公告)号：US20220265797A1

公开(公告)日：2022-08-25

申请号：US17727610

申请日：2022-04-22

Applicant: Gritstone bio, Inc.

Inventor： Karin Jooss ,  Roman Yelensky ,  James Xin Sun ,  Amy Rachel Rappaport ,  Ciaran Daniel Scallan ,  Leonid Gitlin ,  Christine Denise Palmer ,  Monica Lane

IPC: A61K39/00 ,  A61P35/00

Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.