公开(公告)号：US20250025544A1

公开(公告)日：2025-01-23

申请号：US18404681

申请日：2024-01-04

Applicant: Gritstone bio, Inc.

Inventor： Wade Blair ,  Karin Jooss ,  Leonid Gitlin ,  Ciaran Daniel Scallan ,  Amy Rachel Rappaport ,  Gijsbert Grotenbreg

IPC: A61K39/00 ,  C12N15/86

Abstract: Disclosed herein are vectors that include antigen-encoding nucleic acid sequences and co-express immune modulators. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.

公开(公告)号：US20240067985A1

公开(公告)日：2024-02-29

申请号：US18152699

申请日：2023-01-10

Applicant: Gritstone bio, Inc.

Inventor： Wade Blair ,  Brendan Bulik-Sullivan ,  Jennifer Busby ,  Adnan Derti ,  Leonid Gitlin ,  Karin Jooss ,  Ciaran Daniel Scallan ,  Roman Yelensky ,  Gijsbert Grotenbreg

IPC: C12N15/86 ,  A61K35/761 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/74 ,  C07K16/28 ,  C12N7/00

CPC classification number: C12N15/86 ,  A61K35/761 ,  A61K39/0011 ,  A61K39/39541 ,  A61P35/00 ,  C07K14/70539 ,  C07K16/2818 ,  C12N7/00 ,  A61K2039/505 ,  A61K2039/5256 ,  C12N2710/10034 ,  C12N2710/10043 ,  C12N2710/10071

Abstract: Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.