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1.发明申请公开(公告)号：US20230128854A1
公开(公告)日：2023-04-27
申请号：US17554626
申请日：2021-12-17
Applicant: GRAPE KING BIO LTD
Inventor： Chin-Chu CHEN , Yen-Lien CHEN , Shih-Wei LIN , Yen-Po CHEN , Ci-Sian WANG , Yu-Hsin HOU , Yang-Tzu SHIH , Ching-Wen LIN , Ya-Jyun CHEN , Jia-Lin JIANG , You-Shan TSAI , Zi-He WU
IPC: A61K35/742 , A61P25/34 , A61K9/00 , C12N1/20
Abstract: The present invention is related to a method of reducing tobacco addiction in a smoking subject with Lactobacillus fermentum GKF3, including daily administering an oral composition containing the Lactobacillus fermentum GKF3 to the smoking subject, in which the oral composition reduces the total amount of the nicotine metabolites in urine.
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2.发明公开公开(公告)号：US20240165170A1
公开(公告)日：2024-05-23
申请号：US18117573
申请日：2023-03-06
Applicant: GRAPE KING BIO LTD.
Inventor： Chin-Chu CHEN , Yen-Lien CHEN , Shin-Wei LIN , You-Shan TSAI , Ci-Sian WANG , Yu-Hsin HOU , Yang-Tzu SHIH , Ching-Wen LIN , Ya-Jyun CHEN , Jia-Lin JIANG , Zi-He WU , Yen-Po CHEN , Tzu Chun LIN
IPC: A61K35/744 , A23L33/00 , A23L33/135 , A61K35/747 , A61P1/04 , C12N1/20
CPC classification number: A61K35/744 , A23L33/135 , A23L33/40 , A61K35/747 , A61P1/04 , C12N1/20 , A61K2035/115
Abstract: The present invention provides a method for preventing and/or treating a NSAID-induced gastric ulcer. The method comprises administrating an effective amount of a lactic acid bacterium set to a subject. The lactic acid bacterium set comprises Lactobacillus plantarum GKD7 and Pediococcus acidilactici GKA4.
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3.发明申请公开(公告)号：US20200054691A1
公开(公告)日：2020-02-20
申请号：US16541964
申请日：2019-08-15
Applicant: GRAPE KING BIO LTD.
Inventor： Chin-Chu CHEN , Yen-Lien CHEN , Shin-Wei LIN , Yen-Po CHEN , Ci-Sian WANG , Yu-Hsin HOU , Yang-Tzu SHIH , Ching-Wen LIN , Ya-Jyun CHEN , Jia-Lin JIANG
IPC: A61K35/745 , A23L33/135 , A23L2/52 , A61P11/06 , A61K9/19
Abstract: The present invention provides a Bifidobacterium lactis GKK2, a composition comprising thereof and its use for improving asthma, especially for lowering airway resistance, reducing levels of non-specific and specific IgE in serum, alleviating bronchoconstriction and increasing levels of GSH reductase in liver tissue interstitial fluid to improve allergic asthma.
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公开(公告)号：US20240342229A1
公开(公告)日：2024-10-17
申请号：US18756561
申请日：2024-06-27
Applicant: Grape King Bio Ltd
Inventor： Chin-Chu CHEN , Yen-Lien CHEN , Shih-Wei LIN , You-Shan TSAI , Tzu-Chun LIN , Ci-Sian WANG , Yu-Hsin HOU , Yang-Tzu SHIH , Ching-Wen LIN , Ya-Jyun CHEN , Jia-Lin JIANG , Zi-He WU , Yen-Po CHEN
CPC classification number: A61K35/747 , A61K9/0053 , A61K9/19 , C12N1/205 , A61K2035/115 , C12R2001/225 , C12R2001/24 , C12R2001/25
Abstract: The present disclosure relates to an anti-fatigue Lactobacillus composition. The anti-fatigue Lactobacillus composition, which includes at least one of Lactobacillus brevis GKEX, Lactobacillus plantarum GKK1 and Lactobacillus johnsonii GKJ2 as an active ingredient, administered to a healthy subject for a continuous period of time, can significantly improve fatigue-related biochemical indices and prolong aerobic exercise time to exhaustion, and thus can be used as an active ingredient for preparation of various compositions for anti-fatigue and/or improving athletic ability.
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公开(公告)号：US20240139262A1
公开(公告)日：2024-05-02
申请号：US18486674
申请日：2023-10-13
Applicant: GRAPE KING BIO LTD
Inventor： Chin-Chu CHEN , Yen-Lien CHEN , Shih-Wei LIN , Yen-Po CHEN , Ci-Sian WANG , Yu-Hsin HOU , Yang-Tzu SHIH , Ching-Wen LIN , Ya-Jyun CHEN , Jia-Lin JIANG , You-Shan TSAI , Zi-He WU
IPC: A61K35/747 , A61K35/745 , A61P3/04 , A61P3/08 , A61P43/00
CPC classification number: A61K35/747 , A61K35/745 , A61P3/04 , A61P3/08 , A61P43/00 , C12R2001/225
Abstract: The present disclosure relates to a complex probiotic composition and a method for improving exercise performance of a subject with low intrinsic aerobic exercise capacity. The complex probiotic composition, which includes Lactobacillus rhamnosus GKLC1, Bifidobacterium lactis GKK24 and Clostridium butyricum GKB7, administered to the subject with the low intrinsic aerobic exercise capacity in a continuation period, can effectively reduce serum lactic acid and serum urea nitrogen after aerobic exercise, reduce proportion of offal fat and/or increase liver and muscle glycogen contents, thereby being as an effective ingredient for preparation of various compositions.
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Patent Agency Ranking
公开(公告)号：US20220152129A1
公开(公告)日：2022-05-19
申请号：US17514670
申请日：2021-10-29
Applicant: GRAPE KING BIO LTD
Inventor： Hsing-Chun KUO , Chin-Chu CHEN , Yen-Lien CHEN , Shih-Wei LIN , Yen-Po CHEN , Ci-Sian WANG , Yu-Hsin HOU , Yang-Tzu SHIH , Ching-Wen LIN , Ya-Jyun CHEN , Jia-Lin JIANG , You-Shan TSAI , Zi-He WU
IPC: A61K35/747 , A61K9/00 , A61P17/02
Abstract: The present disclosure relates to as external composition for wound healing containing a Lactobacillus fermentation product, which comprises a Lactobacillus fermentation product as an effective component. The Lactobacillus fermentation product is a bacteria-free concentrated filtrate from fermentation of Lactobacillus plantarum and the effective component is loaded onto a pharmaceutically acceptable absorbent carrier or carrying agent. The external composition for wound healing has anti-inflammatory and healing promoting effects on a skin wound after applied directly onto the skin wound.
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公开(公告)号：US20220143114A1
公开(公告)日：2022-05-12
申请号：US17583859
申请日：2022-01-25
Applicant: GRAPE KING BIO LTD.
Inventor： Chin-Chu CHEN , Yen-Lien CHEN , Shin-Wei LIN , Yen-Po CHEN , Ci-Sian WANG , Yu-Hsin HOU , Yang-Tzu SHIH , Ching-Wen LIN , Ya-Jyun CHEN , Jia-Lin JIANG
IPC: A61K35/747 , C12N1/20 , A61K9/19 , A23L33/135 , C12R1/25 , A61K35/00
Abstract: The present invention provides an active substance of Lactic Acid Bacteria, a composition comprising thereof and its use for promoting longevity, especially for increasing Cisd2 gene expression, reducing mitochondrial damage and delaying aging conditions such as nerve degeneration and sarcopenia.
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公开(公告)号：US20220118037A1
公开(公告)日：2022-04-21
申请号：US17499261
申请日：2021-10-12
Applicant: GRAPE KING BIO LTD
Inventor： Chin-Chu CHEN , I-Chen LI , Tsung-Ju LI , Ting-Yu LU , Yen-Po CHEN
Abstract: The invention provides a method for improving sarcopenia of a subject in need thereof by using Phellinus linteus, in which the method includes administering an effective dose of composition to the subject, and the composition includes Phellinus linteus (NITE BP-03321 and BCRC 930210) as an effective substance. By using the aforementioned composition including an extract of a fermented product of the Phellinus linteus and/or its derivative, diameters of myotubes, amounts of muscles and muscle muscular endurance can be maintained, thereby improving sarcopenia.
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公开(公告)号：US20220118036A1
公开(公告)日：2022-04-21
申请号：US17198928
申请日：2021-03-11
Applicant: GRAPE KING BIO LTD.
Inventor： Chin-Chu CHEN , I-Chen LI , Tsung-Ju LI , Ting-Yu LU , Lynn-Huey CHIANG , Yen-Po CHEN
IPC: A61K36/062 , A61K9/19 , A61P21/06
Abstract: The present invention provides a novel use of Morchella active substance. The Morchella active substance is for manufacturing a composition for ameliorating Sarcopenia. The preparation method of the Morchella active substance comprises the following steps: (a) culturing Morchella mycelium in a plate media between 15° C. and 30° C. for 1 to 2 weeks; (b) inoculating the Morchella mycelium cultured in step (a) to a flask and culturing the Morchella mycelium between 15° C. and 30° C. with a pH of 2 to 6 for 4 to 7 days; and (c) inoculating the Morchella mycelium cultured in step (b) to a fermentation tank and culturing the Morchella mycelium between 15° C. and 30° C. with a pH of 2 to 6 for 6 to 10 days, so as to obtain a Morchella mycelium fermentation broth containing the Morchella active substance.
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10.发明申请公开(公告)号：US20210308199A1
公开(公告)日：2021-10-07
申请号：US17349627
申请日：2021-06-16
Applicant: GRAPE KING BIO LTD.
Inventor： Chin-Chu CHEN , Szu-Yin WU , Hsiao-Ling CHANG , Yen-Po CHEN
IPC: A61K36/062 , A61P15/08 , A61K9/19 , A61K47/10 , A61K9/08
Abstract: The present invention provides an active substance of Morchella, its use and a composition thereof for improving disturbance of reproductive function, especially, for manufacturing a pharmaceutical composition to improve disturbance of reproductive function induced by obesity or metabolic syndrome. The composition with the active substance of Morchella can effectively improve the structural integrity of testicular tissues and sperm, increase testosterone levels in the blood, and reduce the oxidation stress in sperms.
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