公开(公告)号：US20230128854A1

公开(公告)日：2023-04-27

申请号：US17554626

申请日：2021-12-17

Applicant: GRAPE KING BIO LTD

Inventor： Chin-Chu CHEN ,  Yen-Lien CHEN ,  Shih-Wei LIN ,  Yen-Po CHEN ,  Ci-Sian WANG ,  Yu-Hsin HOU ,  Yang-Tzu SHIH ,  Ching-Wen LIN ,  Ya-Jyun CHEN ,  Jia-Lin JIANG ,  You-Shan TSAI ,  Zi-He WU

IPC: A61K35/742 ,  A61P25/34 ,  A61K9/00 ,  C12N1/20

Abstract: The present invention is related to a method of reducing tobacco addiction in a smoking subject with Lactobacillus fermentum GKF3, including daily administering an oral composition containing the Lactobacillus fermentum GKF3 to the smoking subject, in which the oral composition reduces the total amount of the nicotine metabolites in urine.

公开(公告)号：US20240342229A1

公开(公告)日：2024-10-17

申请号：US18756561

申请日：2024-06-27

Applicant: Grape King Bio Ltd

Inventor： Chin-Chu CHEN ,  Yen-Lien CHEN ,  Shih-Wei LIN ,  You-Shan TSAI ,  Tzu-Chun LIN ,  Ci-Sian WANG ,  Yu-Hsin HOU ,  Yang-Tzu SHIH ,  Ching-Wen LIN ,  Ya-Jyun CHEN ,  Jia-Lin JIANG ,  Zi-He WU ,  Yen-Po CHEN

IPC: A61K35/747 ,  A61K9/00 ,  A61K9/19 ,  A61K35/00 ,  C12N1/20 ,  C12R1/225 ,  C12R1/24 ,  C12R1/25

CPC classification number: A61K35/747 ,  A61K9/0053 ,  A61K9/19 ,  C12N1/205 ,  A61K2035/115 ,  C12R2001/225 ,  C12R2001/24 ,  C12R2001/25

Abstract: The present disclosure relates to an anti-fatigue Lactobacillus composition. The anti-fatigue Lactobacillus composition, which includes at least one of Lactobacillus brevis GKEX, Lactobacillus plantarum GKK1 and Lactobacillus johnsonii GKJ2 as an active ingredient, administered to a healthy subject for a continuous period of time, can significantly improve fatigue-related biochemical indices and prolong aerobic exercise time to exhaustion, and thus can be used as an active ingredient for preparation of various compositions for anti-fatigue and/or improving athletic ability.

公开(公告)号：US20240139262A1

公开(公告)日：2024-05-02

申请号：US18486674

申请日：2023-10-13

Applicant: GRAPE KING BIO LTD

Inventor： Chin-Chu CHEN ,  Yen-Lien CHEN ,  Shih-Wei LIN ,  Yen-Po CHEN ,  Ci-Sian WANG ,  Yu-Hsin HOU ,  Yang-Tzu SHIH ,  Ching-Wen LIN ,  Ya-Jyun CHEN ,  Jia-Lin JIANG ,  You-Shan TSAI ,  Zi-He WU

IPC: A61K35/747 ,  A61K35/745 ,  A61P3/04 ,  A61P3/08 ,  A61P43/00

CPC classification number: A61K35/747 ,  A61K35/745 ,  A61P3/04 ,  A61P3/08 ,  A61P43/00 ,  C12R2001/225

Abstract: The present disclosure relates to a complex probiotic composition and a method for improving exercise performance of a subject with low intrinsic aerobic exercise capacity. The complex probiotic composition, which includes Lactobacillus rhamnosus GKLC1, Bifidobacterium lactis GKK24 and Clostridium butyricum GKB7, administered to the subject with the low intrinsic aerobic exercise capacity in a continuation period, can effectively reduce serum lactic acid and serum urea nitrogen after aerobic exercise, reduce proportion of offal fat and/or increase liver and muscle glycogen contents, thereby being as an effective ingredient for preparation of various compositions.

公开(公告)号：US20220152129A1

公开(公告)日：2022-05-19

申请号：US17514670

申请日：2021-10-29

Applicant: GRAPE KING BIO LTD

Inventor： Hsing-Chun KUO ,  Chin-Chu CHEN ,  Yen-Lien CHEN ,  Shih-Wei LIN ,  Yen-Po CHEN ,  Ci-Sian WANG ,  Yu-Hsin HOU ,  Yang-Tzu SHIH ,  Ching-Wen LIN ,  Ya-Jyun CHEN ,  Jia-Lin JIANG ,  You-Shan TSAI ,  Zi-He WU

IPC: A61K35/747 ,  A61K9/00 ,  A61P17/02

Abstract: The present disclosure relates to as external composition for wound healing containing a Lactobacillus fermentation product, which comprises a Lactobacillus fermentation product as an effective component. The Lactobacillus fermentation product is a bacteria-free concentrated filtrate from fermentation of Lactobacillus plantarum and the effective component is loaded onto a pharmaceutically acceptable absorbent carrier or carrying agent. The external composition for wound healing has anti-inflammatory and healing promoting effects on a skin wound after applied directly onto the skin wound.

公开(公告)号：US20200155623A1

公开(公告)日：2020-05-21

申请号：US16675667

申请日：2019-11-06

Applicant: GRAPE KING BIO LTD

Inventor： Chin-Chu CHEN ,  Yen-Lien CHEN ,  Shih-Wei LIN ,  Szu-Yin WU ,  Yen-Po CHEN ,  Yu-Hsin HOU ,  Ci-Sian WANG ,  Yang-Tzu SHIH ,  Jia-Lin JIANG

IPC: A61K35/747 ,  A23L29/00 ,  A61P25/00

Abstract: The present invention provides a Lactobacillus fermentum GKF3, a composition comprising the strain and their use, in which the aforementioned Lactobacillus fermentum GKF3, deposited with accession numbers of BCRC 910824 and CGMCC 15203, can increase the levels of dopamine or/and serotonin in brain tissues, thereby improving the symptoms of the psychataxia such as decreased focus.