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1.发明授权Blocking histamine H.sub.2 -receptors with imidazolylalkyl guanidine derivatives 失效用咪唑烷基胍衍生物封闭组胺H2受体
公开(公告)号：US4333946A
公开(公告)日：1982-06-08
申请号：US229435
申请日：1981-01-29
Applicant: Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
IPC: C07D233/54 , C07D233/64 , C07D233/68 , C07D263/32 , C07D277/22 , C07D277/26 , C07D277/28 , A61K31/415
CPC classification number: C07D233/64 , C07D277/26 , Y10S514/926 , Y10S514/927
Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
Abstract translation: 该化合物是组胺H 2拮抗剂的新型N-取代-N'-杂环烷基硫脲，胍和1-硝基-2,2-二氨基亚乙基化合物。
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公开(公告)号：US4247558A
公开(公告)日：1981-01-27
申请号：US35152
申请日：1979-05-02
Applicant: Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
IPC: C07D233/54 , C07D233/64 , C07D233/68 , C07D263/32 , C07D277/22 , C07D277/26 , C07D277/28 , C07D213/53 , A61K31/44
CPC classification number: C07D233/64 , C07D277/26 , Y10S514/926 , Y10S514/927
Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
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公开(公告)号：US4191769A
公开(公告)日：1980-03-04
申请号：US896846
申请日：1978-04-17
Applicant: Graham J. Durant , Charon R. Ganellin , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Rodney C. Young
IPC: A61K31/33 , C07D249/08 , C07D261/14 , C07D275/02 , C07D277/26 , C07D277/48 , C07D285/12 , A61K31/425 , A61K31/44 , C07D213/59 , C07D277/30
CPC classification number: C07D275/02 , A61K31/33 , C07D249/08 , C07D261/14 , C07D277/26 , C07D277/48 , C07D285/12
Abstract: The compounds are N-(heterocyclomethylthioalkyl) derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'(heterocyclomethylthioalkyl) substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
Abstract translation: 这些化合物是烷基胍，C-烷基和C芳基脒和S-烷基异硫脲的N-（杂环甲硫基烷基）衍生物。 化合物也可以具有N' - 低级烷基或N'（杂环甲硫基烷基）取代基。 本发明的三种化合物是S-甲基-N- [2-（5-甲基-4-咪唑基甲硫基）乙基]异硫脲，N，N'-双[2-（5-甲基-4-咪唑基甲硫基）乙基]乙脒 ，N，N'-二 - [2-（5-甲基-4-咪唑基甲硫基）乙基] N“ - 甲基胍。 本发明的化合物是组胺H2拮抗剂。
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公开(公告)号：US4170652A
公开(公告)日：1979-10-09
申请号：US896848
申请日：1978-04-17
Applicant: Graham J. Durant , Charon R. Ganellin , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Rodney C. Young
IPC: A61K31/33 , C07D249/08 , C07D261/14 , C07D275/02 , C07D277/26 , C07D277/48 , C07D285/12 , C07D213/53 , A61K31/41 , A61K31/44
CPC classification number: C07D275/02 , A61K31/33 , C07D249/08 , C07D261/14 , C07D277/26 , C07D277/48 , C07D285/12
Abstract: The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
Abstract translation: 这些化合物是烷基胍，C-烷基和C芳基脒和S-烷基异硫脲的N-（杂环甲硫基烷基）衍生物。 化合物也可以具有N' - 低级烷基或N' - （杂环甲硫基烷基）取代基。 本发明的三种化合物是S-甲基-N- [2-（5-甲基-4-咪唑基甲硫基）乙基]异硫脲，N，N'-双[2-（5-甲基-4-咪唑基甲硫基）乙基]乙脒 ，N，N'-二 - [2-（5-甲基-4-咪唑基甲硫基）乙基] N“ - 甲基胍。 本发明的化合物是组胺H2拮抗剂。
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5.发明授权
公开(公告)号：US4440775A
公开(公告)日：1984-04-03
申请号：US389837
申请日：1982-06-18
Applicant: Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
IPC: C07D233/54 , C07D233/64 , C07D233/68 , C07D263/32 , C07D277/22 , C07D277/26 , C07D277/28 , A61K31/425 , A61K31/41 , A61K31/42
CPC classification number: C07D233/64 , C07D277/26 , Y10S514/926 , Y10S514/927
Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
Abstract translation: 该化合物是组胺H 2拮抗剂的新型N-取代-N'-杂环烷基硫脲，胍和1-硝基-2,2-二氨基亚乙基化合物。
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Patent Agency Ranking
公开(公告)号：US4395419A
公开(公告)日：1983-07-26
申请号：US291196
申请日：1981-08-10
Applicant: Graham J. Durant , Charon R. Ganellin , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Rodney C. Young
IPC: A61K31/4164 , A61K31/42 , A61K31/425 , A61P1/04 , A61P29/00 , C07D213/61 , C07D213/65 , C07D233/54 , C07D233/64 , C07D277/26 , C07D277/28 , C07D277/32 , C07D285/10 , C07D285/12
CPC classification number: C07D233/64 , C07D277/26 , Y10S514/926 , Y10S514/927
Abstract: Amidinoformic acids and amidinosulphinic acids which are histamine H.sub.2 -antagonists. A specific compound of this invention is N-[2-(3-(1,2,5)-thiadiazolylmethylthio)ethyl]amidinoformic acid.
Abstract translation: 作为组胺H2拮抗剂的脒基甲酸和脒基亚磺酸。 本发明的具体化合物是N- [2-（3-（1,2,5） - 噻二唑甲基硫代）乙基]脒基甲酸。
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公开(公告)号：US4276301A
公开(公告)日：1981-06-30
申请号：US070184
申请日：1979-08-27
Applicant: Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
IPC: C07D233/54 , C07D233/64 , C07D233/68 , C07D263/32 , C07D277/22 , C07D277/26 , C07D277/28 , A61K31/415
CPC classification number: C07D233/64 , C07D277/26 , Y10S514/926 , Y10S514/927
Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
Abstract translation: 该化合物是组胺H 2拮抗剂的新型N-取代-N'-杂环烷基硫脲，胍和1-硝基-2,2-二氨基亚乙基化合物。
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公开(公告)号：US4192879A
公开(公告)日：1980-03-11
申请号：US892232
申请日：1978-03-31
Applicant: Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
IPC: C07D233/54 , C07D233/64 , C07D277/26 , A61K31/415
CPC classification number: C07D233/64 , C07D277/26
Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
Abstract translation: 该化合物是组胺H 2拮抗剂的新型N-取代-N'-杂环烷基硫脲，胍和1-硝基-2,2-二氨基亚乙基化合物。
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公开(公告)号：US4347250A
公开(公告)日：1982-08-31
申请号：US183555
申请日：1980-09-02
Applicant: Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Geoffrey R. Owen , Rodney C. Young
IPC: C07D233/54 , C07D233/64 , C07D233/68 , C07D263/32 , C07D277/22 , C07D277/26 , C07D277/28 , C07D213/64 , A61K31/44 , C07D213/75
CPC classification number: C07D233/64 , C07D277/26 , Y10S514/926 , Y10S514/927
Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
Abstract translation: 该化合物是组胺H 2拮抗剂的新型N-取代-N'-杂环烷基硫脲，胍和1-硝基-2,2-二氨基亚乙基化合物。
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10.发明授权Thiazole and isothiazole compounds, pharmaceutical compositions and their method of use 失效噻唑和异噻唑化合物，药物组合物及其使用方法
公开(公告)号：US4308275A
公开(公告)日：1981-12-29
申请号：US65478
申请日：1979-08-10
Applicant: Graham J. Durant , Charon R. Ganellin , Rodney C. Young
Inventor： Graham J. Durant , Charon R. Ganellin , Rodney C. Young
IPC: A61K31/4164 , A61K31/42 , A61K31/425 , A61P1/04 , A61P29/00 , C07D213/61 , C07D213/65 , C07D233/54 , C07D233/64 , C07D277/26 , C07D277/28 , C07D277/32
CPC classification number: C07D233/64 , C07D277/26 , Y10S514/926 , Y10S514/927
Abstract: Amidinoformic acids and amidinosulphinic acids which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]amidinoformic acid and N-methyl-N'-[2-(5-methyl-4-imidazolylmethylthio)ethyl]amidinosulphinic acid.
Abstract translation: 作为组胺H2拮抗剂的脒基甲酸和脒基亚磺酸。 本发明的两种具体化合物是N- [2-（5-甲基-4-咪唑基甲硫基）乙基]脒基甲酸和N-甲基-N' - [2-（5-甲基-4-咪唑基甲硫基）乙基]脒基亚磺酸 。
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