公开(公告)号：US20160310486A1

公开(公告)日：2016-10-27

申请号：US15135588

申请日：2016-04-22

申请人： GRÜNENTHAL GMBH

发明人： Klaus WENING ,  Lutz BARNSCHEID ,  Anja GEIßLER ,  Jana DENKER ,  Jessica REDMER

IPC分类号： A61K31/485 ,  A61K9/20 ,  A61K31/167 ,  A61K9/16 ,  A61K9/48 ,  A61K45/06

CPC分类号： A61K31/485 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/2031 ,  A61K9/4866 ,  A61K31/135 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/407 ,  A61K45/06 ,  A61K2300/00

摘要： A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.

摘要翻译： 包含两种药理学活性成分的抗篡改药物剂型，其中所述剂型在体外条件下提供快速释放，优选根据Ph.Eur。立即释放两种药理活性成分。 剂型可用于药物联合治疗，其通过施用含有多于一种药理学活性成分的剂型作为固定剂量组合来实现。

公开(公告)号：US20180369149A1

公开(公告)日：2018-12-27

申请号：US16117712

申请日：2018-08-30

申请人： Grünenthal GmbH

发明人： Sebastian Schwier ,  Marcel Haupts ,  Udo Rüttgers ,  Lutz Barnscheid ,  Jana DENKER

IPC分类号： A61K9/20 ,  A61K31/137 ,  A61K31/485 ,  A61K9/28 ,  A61K31/135 ,  A61K31/138

摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.

公开(公告)号：US20180044348A1

公开(公告)日：2018-02-15

申请号：US15791563

申请日：2017-10-24

申请人： Grünenthal Gmbh

发明人： Klaus WENING ,  Lutz BARNSCHEID ,  Anja GEISSLER ,  Jana DENKER ,  Dagmar LISCHKE

IPC分类号： C07D489/04

CPC分类号： C07D489/04 ,  C07B2200/13

摘要： Crystalline salts of 7,8-Didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6 alpha-diol sulfate(2:1), i.e. of morphine sulphate, are disclosed and four polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising an amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

公开(公告)号：US20190269621A1

公开(公告)日：2019-09-05

申请号：US16416532

申请日：2019-05-20

申请人： Grünenthal GmbH

发明人： Sebastian SCHWIER ,  Marcel Haupts ,  Udo Rüttgers ,  Lutz Barnscheid ,  Jana DENKER

IPC分类号： A61K9/20 ,  A61K31/485 ,  A61K31/138 ,  A61K31/137 ,  A61K31/135 ,  A61K9/28

摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.

公开(公告)号：US20180044347A1

公开(公告)日：2018-02-15

申请号：US15791508

申请日：2017-10-24

申请人： GRÜNENTHAL GMBH

发明人： Klaus WENING ,  Lutz BARNSCHEID ,  Anja GEISSLER ,  Jana DENKER ,  Dagmar LISCHKE

IPC分类号： C07D489/04

CPC分类号： C07D489/04 ,  A61P25/04 ,  A61P29/00 ,  C07B2200/13 ,  C07D489/02

摘要： Crystalline salts of 4,5 α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) (hydrocodone bitartrate) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

公开(公告)号：US20160310487A1

公开(公告)日：2016-10-27

申请号：US15169778

申请日：2016-06-01

申请人： GRÜNENTHAL GMBH

发明人： Klaus WENING ,  Anja GEIßLER ,  Jana DENKER ,  Lutz BARNSCHEID

IPC分类号： A61K31/485 ,  A61K9/48 ,  A61K31/137 ,  A61K9/20 ,  A61K9/16 ,  A61K9/50

CPC分类号： A61K31/485 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/2077 ,  A61K9/4808 ,  A61K9/50 ,  A61K31/137

摘要： A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.