公开(公告)号：US10695297B2

公开(公告)日：2020-06-30

申请号：US16416532

申请日：2019-05-20

申请人： Grünenthal GmbH

发明人： Sebastian Schwier ,  Marcel Haupts ,  Udo Rüttgers ,  Lutz Barnscheid ,  Jana Denker

IPC分类号： A61K9/20 ,  A61K31/135 ,  A61K9/28 ,  A61K31/137 ,  A61K31/138 ,  A61K31/485

摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.

公开(公告)号：US20180369149A1

公开(公告)日：2018-12-27

申请号：US16117712

申请日：2018-08-30

申请人： Grünenthal GmbH

发明人： Sebastian Schwier ,  Marcel Haupts ,  Udo Rüttgers ,  Lutz Barnscheid ,  Jana DENKER

IPC分类号： A61K9/20 ,  A61K31/137 ,  A61K31/485 ,  A61K9/28 ,  A61K31/135 ,  A61K31/138

摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.

公开(公告)号：US20190269621A1

公开(公告)日：2019-09-05

申请号：US16416532

申请日：2019-05-20

申请人： Grünenthal GmbH

发明人： Sebastian SCHWIER ,  Marcel Haupts ,  Udo Rüttgers ,  Lutz Barnscheid ,  Jana DENKER

IPC分类号： A61K9/20 ,  A61K31/485 ,  A61K31/138 ,  A61K31/137 ,  A61K31/135 ,  A61K9/28

摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.

公开(公告)号：US20160199306A1

公开(公告)日：2016-07-14

申请号：US15073920

申请日：2016-03-18

申请人： Grünenthal GmbH

发明人： Sebastian Schwier ,  Marcel Haupts ,  Udo Rüttgers ,  Lutz Barnscheid ,  Jana Pätz

IPC分类号： A61K9/20 ,  A61K31/137 ,  A61K9/28 ,  A61K31/135

CPC分类号： A61K9/2077 ,  A61K9/2031 ,  A61K9/2081 ,  A61K9/28 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/485

摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.