公开(公告)号：US20180044348A1

公开(公告)日：2018-02-15

申请号：US15791563

申请日：2017-10-24

申请人： Grünenthal Gmbh

发明人： Klaus WENING ,  Lutz BARNSCHEID ,  Anja GEISSLER ,  Jana DENKER ,  Dagmar LISCHKE

IPC分类号： C07D489/04

CPC分类号： C07D489/04 ,  C07B2200/13

摘要： Crystalline salts of 7,8-Didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6 alpha-diol sulfate(2:1), i.e. of morphine sulphate, are disclosed and four polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising an amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

公开(公告)号：US20180044347A1

公开(公告)日：2018-02-15

申请号：US15791508

申请日：2017-10-24

申请人： GRÜNENTHAL GMBH

发明人： Klaus WENING ,  Lutz BARNSCHEID ,  Anja GEISSLER ,  Jana DENKER ,  Dagmar LISCHKE

IPC分类号： C07D489/04

CPC分类号： C07D489/04 ,  A61P25/04 ,  A61P29/00 ,  C07B2200/13 ,  C07D489/02

摘要： Crystalline salts of 4,5 α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) (hydrocodone bitartrate) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

公开(公告)号：US20210261492A1

公开(公告)日：2021-08-26

申请号：US17194717

申请日：2021-03-08

申请人： Grünenthal GmbH

发明人： Andreas FISCHER ,  Helmut BUSCHMANN ,  Michael GRUSS ,  Dagmar LISCHKE

IPC分类号： C07C213/10 ,  C07C215/54

摘要： A hitherto unknown crystalline form of (−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.

公开(公告)号：US20190062263A1

公开(公告)日：2019-02-28

申请号：US16172100

申请日：2018-10-26

申请人： Grünenthal GmbH

发明人： Andreas FISCHER ,  Helmut BUSCHMANN ,  Michael GRUSS ,  Dagmar LISCHKE

IPC分类号： C07C213/10 ,  C07C215/54

摘要： A hitherto unknown crystalline form of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.

公开(公告)号：US20140088132A1

公开(公告)日：2014-03-27

申请号：US14091399

申请日：2013-11-27

申请人： GRÜNENTHAL GMBH

发明人： Andreas FISCHER ,  Dagmar PETERS-GROTH ,  Dagmar LISCHKE

IPC分类号： C07D489/08

CPC分类号： C07D489/08 ,  C07B2200/13

摘要： Crystalline, anhydrous hydrochloride salts of 4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

摘要翻译： 公开了4,5α-环氧-3,14-二羟基-17-甲基吗啡喃-6-酮（羟吗啡酮）的结晶无水盐酸盐，并报道了这些盐的三种多晶形式。 本发明进一步涉及一种生产这种盐的方法，一种药物组合物，其包含有效量的这种盐和这种盐作为药物，以及用于治疗和/或预防疼痛。