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公开(公告)号：US12077743B2
公开(公告)日：2024-09-03
申请号：US16968333
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
CPC分类号： C12M29/04 , C12M23/08 , C12M23/24 , C12M25/02 , C12M25/06 , C12M29/18 , C12M29/26 , C12M33/00 , C12M41/46 , C12N5/0636
摘要： In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.
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公开(公告)号：US20220251496A1
公开(公告)日：2022-08-11
申请号：US17734562
申请日：2022-05-02
发明人： Weston Blaine Griffin , Alex D. Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.
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公开(公告)号：US20240200012A1
公开(公告)日：2024-06-20
申请号：US18410607
申请日：2024-01-11
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.
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公开(公告)号：US11414639B2
公开(公告)日：2022-08-16
申请号：US16968306
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.
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公开(公告)号：US11371007B2
公开(公告)日：2022-06-28
申请号：US16968391
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.
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公开(公告)号：US20210087510A1
公开(公告)日：2021-03-25
申请号：US16968304
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： A system for bioprocessing includes a tray having plurality of sidewalls and a bottom surface defining an interior compartment, and a generally open top, and an opening formed in the bottom surface of the tray, the opening having a perimeter. The perimeter of the opening is shaped and/or dimensioned such that a bioreactor vessel can be positioned above the opening and supported by the bottom surface of the tray while a portion of the bioreactor vessel is accessible through the opening in the bottom surface. The tray is receivable within a processing chamber such that the bed plate extends through the opening in the bottom surface of the tray to support the bioreactor vessel.
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公开(公告)号：US20240132826A1
公开(公告)日：2024-04-25
申请号：US18400052
申请日：2023-12-29
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
CPC分类号： C12M29/10 , C12M23/24 , C12M23/44 , C12M25/02 , C12M29/04 , C12M29/18 , C12M41/26 , C12M41/34 , C12M41/36 , C12M41/44 , C12M41/46
摘要： An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.
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公开(公告)号：US11932842B2
公开(公告)日：2024-03-19
申请号：US16968331
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
CPC分类号： C12M29/10 , C12M23/24 , C12M23/44 , C12M25/02 , C12M29/04 , C12M29/18 , C12M41/26 , C12M41/34 , C12M41/36 , C12M41/44 , C12M41/46
摘要： An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.
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公开(公告)号：US20210102156A1
公开(公告)日：2021-04-08
申请号：US16968331
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.
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公开(公告)号：US20240279585A1
公开(公告)日：2024-08-22
申请号：US18651024
申请日：2024-04-30
发明人： Weston Blaine Griffin , Alex D. Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
CPC分类号： C12M29/04 , C12M23/08 , C12M23/24 , C12M25/02 , C12M25/06 , C12M29/18 , C12M29/26 , C12M33/00 , C12M41/46 , C12N5/0636
摘要： In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.
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