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公开(公告)号：US12077743B2
公开(公告)日：2024-09-03
申请号：US16968333
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
CPC分类号： C12M29/04 , C12M23/08 , C12M23/24 , C12M25/02 , C12M25/06 , C12M29/18 , C12M29/26 , C12M33/00 , C12M41/46 , C12N5/0636
摘要： In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.
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公开(公告)号：US20220251496A1
公开(公告)日：2022-08-11
申请号：US17734562
申请日：2022-05-02
发明人： Weston Blaine Griffin , Alex D. Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.
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公开(公告)号：US11027239B2
公开(公告)日：2021-06-08
申请号：US15726013
申请日：2017-10-05
IPC分类号： B01D63/08 , B01D25/21 , B01D61/18 , C12M3/06 , C12M1/26 , B01D69/10 , A61N1/34 , C12M1/00 , A61M1/34 , B01D61/14 , B01D69/02
摘要： A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.
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公开(公告)号：US20240132826A1
公开(公告)日：2024-04-25
申请号：US18400052
申请日：2023-12-29
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
CPC分类号： C12M29/10 , C12M23/24 , C12M23/44 , C12M25/02 , C12M29/04 , C12M29/18 , C12M41/26 , C12M41/34 , C12M41/36 , C12M41/44 , C12M41/46
摘要： An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.
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公开(公告)号：US11932842B2
公开(公告)日：2024-03-19
申请号：US16968331
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
CPC分类号： C12M29/10 , C12M23/24 , C12M23/44 , C12M25/02 , C12M29/04 , C12M29/18 , C12M41/26 , C12M41/34 , C12M41/36 , C12M41/44 , C12M41/46
摘要： An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.
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公开(公告)号：US20210102156A1
公开(公告)日：2021-04-08
申请号：US16968331
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.
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公开(公告)号：US20240279585A1
公开(公告)日：2024-08-22
申请号：US18651024
申请日：2024-04-30
发明人： Weston Blaine Griffin , Alex D. Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
CPC分类号： C12M29/04 , C12M23/08 , C12M23/24 , C12M25/02 , C12M25/06 , C12M29/18 , C12M29/26 , C12M33/00 , C12M41/46 , C12N5/0636
摘要： In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.
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公开(公告)号：US11920119B2
公开(公告)日：2024-03-05
申请号：US16968342
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.
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公开(公告)号：US20210102157A1
公开(公告)日：2021-04-08
申请号：US16968306
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.
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公开(公告)号：US20210102153A1
公开(公告)日：2021-04-08
申请号：US16968333
申请日：2019-02-08
发明人： Weston Blaine Griffin , Alex D Corwin , Xiaohua Zhang , Reginald Donovan Smith , Zhen Liu , Chengkun Zhang , Vandana Keskar , Brian Michael Davis , Kashan Shaikh
摘要： In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.
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