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公开(公告)号：US20150274774A1
公开(公告)日：2015-10-01
申请号：US14740680
申请日：2015-06-16
发明人： Caroline Aciro , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Petr Jansa , Kapil Kumar Karki , Andrew J. Keats , Linos Lazarides , Richard L. Mackman , Simon N. Pettit , Karine G. Poullennec , Adam James Schrier , Dustin Siegel , Victoria Alexandria Steadman
IPC分类号： C07K5/062
CPC分类号： C07K5/06034 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , A61K38/00 , A61K38/05 , A61K38/12 , A61K38/15 , A61K38/21 , A61K38/55 , A61K39/29 , A61K45/06 , C07D471/18 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06191 , C07K19/00 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395 , A61K2300/00
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US20170190737A1
公开(公告)日：2017-07-06
申请号：US15465492
申请日：2017-03-21
发明人： Caroline Aciro , David Kenneth Dean , Neil Andrew Dunbar , Adrian John Highton , Petr Jansa , Kapil Kumar Karki , Andrew John Keats , Linos Lazarides , Richard L. Mackman , Simon N. Pettit , Karine G. Poullennec , Adam James Schrier , Dustin Siegel , Victoria Alexandra Steadman
IPC分类号： C07K5/062 , C07K5/078 , A61K45/06 , C07K5/06 , C07K19/00 , A61K38/05 , C07K5/065 , C07K5/068
CPC分类号： C07K5/06034 , A61K31/403 , A61K31/497 , A61K31/504 , A61K31/7056 , A61K31/7072 , A61K38/00 , A61K38/05 , A61K38/12 , A61K38/15 , A61K38/21 , A61K38/55 , A61K39/29 , A61K45/06 , C07D471/18 , C07D487/08 , C07D498/08 , C07D498/18 , C07D498/22 , C07K5/02 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06191 , C07K19/00 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/395 , A61K2300/00
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
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公开(公告)号：US11266666B2
公开(公告)日：2022-03-08
申请号：US16881419
申请日：2020-05-22
发明人： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056 , A61K31/685 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US20210052613A1
公开(公告)日：2021-02-25
申请号：US16881419
申请日：2020-05-22
发明人： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/685 , A61K31/706 , A61K31/7056 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US10695361B2
公开(公告)日：2020-06-30
申请号：US16265016
申请日：2019-02-01
发明人： Michael O'Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US20190275063A1
公开(公告)日：2019-09-12
申请号：US16274049
申请日：2019-02-12
发明人： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/685 , A61K31/683 , A61K31/706 , A61K31/6615 , C07H15/18 , C07H11/00 , C07H1/02 , C07H1/00 , A61K31/53 , A61K31/675 , C07F9/6561 , C07F9/24 , C07D519/00 , C07D487/04 , A61K31/00 , A61K45/06 , A61K31/7056 , A61K31/665
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US20190008858A1
公开(公告)日：2019-01-10
申请号：US16005111
申请日：2018-06-11
发明人： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC分类号： A61K31/498 , C07K5/08 , A61K31/10 , C07K5/083 , C07D498/22 , C07D498/16 , C07D403/14 , C07D241/36 , A61K45/06 , A61K38/21 , A61K38/06 , C07K5/087 , A61K31/519 , A61K31/506 , A61K31/4985 , A61K31/4745 , A61K31/401 , A61K38/00
CPC分类号： A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
摘要： Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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![PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT](/abs-image/US/2018/10/18/US20180298011A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180298011A1
公开(公告)日：2018-10-18
申请号：US15923726
申请日：2018-03-16
发明人： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC分类号： C07D487/04 , A61K45/06 , C07F9/6561 , C07D519/00 , A61K31/519 , C07D495/04 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , C07D513/04
摘要： The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号：US20170210756A1
公开(公告)日：2017-07-27
申请号：US15227527
申请日：2016-08-03
发明人： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Christopher Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC分类号： C07D498/18 , C07C271/34 , C07C255/61 , C07C205/57 , C07C233/09 , C07C251/12 , C07D403/12 , C07D241/44
CPC分类号： C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US09504689B2
公开(公告)日：2016-11-29
申请号：US14635830
申请日：2015-03-02
发明人： Dustin Siegel , David Sperandio , Hai Yang , Michael Sangi , Jay P. Parrish , Hon Chung Hui
IPC分类号： A61K31/519 , A61K31/5377 , C07D487/04 , C07D519/00 , C07D471/04 , A61K45/06 , A61K31/4545 , A61K31/5025 , A61K31/53
CPC分类号： C07D487/04 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D519/00
摘要： Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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