公开(公告)号：US20110009474A1

公开(公告)日：2011-01-13

申请号：US12595353

申请日：2008-04-14

申请人： David A. Sinclair ,  Ron Firestein ,  Leonard Guarente ,  Gil Blander

发明人： David A. Sinclair ,  Ron Firestein ,  Leonard Guarente ,  Gil Blander

IPC分类号： A61K31/7088 ,  A61P35/00 ,  A61P17/02 ,  A61P13/12 ,  A61P19/04 ,  A61P17/00 ,  A61P37/00 ,  C12N5/02 ,  G01N33/566

CPC分类号： A61K38/50

摘要： Provided herein are methods and compositions relating to sirtuin modulation of Wnt pathway signaling, including the use of sirtuin and sirtuin-modulating agents in the prevention and treatment of cancer and other diseases.

摘要翻译： 本文提供了关于Wnt途径信号传递的沉默调节调节的方法和组合物，包括在预防和治疗癌症和其它疾病中使用沉默调节蛋白和沉默调节蛋白的调节剂。

公开(公告)号：US20050164969A1

公开(公告)日：2005-07-28

申请号：US10993903

申请日：2004-11-19

申请人： Gil Blander ,  Leonard Guarente

发明人： Gil Blander ,  Leonard Guarente

IPC分类号： A61K48/00 ,  C07H21/04 ,  C07K14/47 ,  C12N9/18

CPC分类号： C12N9/18 ,  C07K14/4746

摘要： The present invention provides new and advantageous methods, compositions, cell constructs and animal models related to inhibiting the senescence of vertebrate cells and vertebrate organisms based on the use of SIRT1 polynucleotides and polypeptides, as well as mutant SIRT1 polynucleotides and polypeptides. The invention provides polynucleotides that encode variants and fragments of SIRT1 polypeptides, and also provides variant SIRT1 polypeptides and fragments thereof. Additionally the invention provides a method of inhibiting or delaying the expression in a vertebrate cell of a protein having biological activity associated with loss of population doubling in the cell. The invention further provides a method of treating a pathology, a disease or a medical condition in a subject, wherein the pathology responds to an SIRT1 polypeptide. The invention also provides a vertebrate cell that incorporates a heterologous nucleic acid encoding a variant of SIRT1, or a fragment thereof, as well as a transgenic mammal a majority of whose cells harbor a transgene including a nucleic acid sequence encoding an SIRT1 polypeptide. The invention also provides an antibody that binds immunospecifically to a variant SIRT1 polypeptide or a fragment thereof, and a method of determining whether the amount of an SIRT1 polypeptide in a sample differs from the amount of the SIRT1 polypeptide in a reference. The invention further provides a method of contributing to the diagnosis or prognosis of, or to developing a therapeutic strategy for, a disease or pathology in a subject, wherein the disease or pathology responds to treatment with an SIRT1 polypeptide and wherein the amount of SIRT1 polypeptide in the pathology is known to differ from the amount of the SIRT1 polypeptide in a nonpathological state.

摘要翻译： 本发明提供了基于使用SIRT1多核苷酸和多肽以及突变型SIRT1多核苷酸和多肽来抑制脊椎动物细胞和脊椎动物生物衰老有关的新的和有利的方法，组合物，细胞构建体和动物模型。 本发明提供编码SIRT1多肽的变体和片段的多核苷酸，并且还提供变体SIRT1多肽及其片段。 另外，本发明提供了抑制或延迟具有生物活性的蛋白质的脊椎动物细胞中表达的方法，所述生物活性与细胞中群体倍增的丧失相关。 本发明还提供了治疗受试者的病理学，疾病或医学病症的方法，其中所述病理学响应于SIRT1多肽。 本发明还提供了一种脊椎动物细胞，其包含编码SIRT1的变体或其片段的异源核酸，以及转基因哺乳动物，其大部分细胞含有包含编码SIRT1多肽的核酸序列的转基因。 本发明还提供了与变体SIRT1多肽或其片段免疫特异性结合的抗体，以及确定样品中SIRT1多肽的量是否与参考文献中SIRT1多肽的量不同的方法。 本发明进一步提供了一种有助于对受试者的疾病或病理学的诊断或预后或制定治疗策略的方法，其中所述疾病或病理学响应于SIRT1多肽的治疗，并且其中SIRT1多肽的量 在病理学中已知与非病理状态下SIRT1多肽的量不同。

公开(公告)号：US08762167B2

公开(公告)日：2014-06-24

申请号：US13190996

申请日：2011-07-26

申请人： Gil Blander ,  Christian Reich ,  David Lester

发明人： Gil Blander ,  Christian Reich ,  David Lester

IPC分类号： G06Q50/22 ,  G06Q10/10 ,  G06F19/10 ,  G06F19/00

CPC分类号： G06F19/3475 ,  G06F19/00 ,  G06F19/10 ,  G06F19/20 ,  G06F19/24 ,  G06F19/3481 ,  G06Q10/10 ,  G06Q50/22

摘要： Personalized, health and performance programs are generated for individuals based on various biomarkers and performance and lifestyle assessments. In one embodiment, a diagnostic test of blood or other biological specimen(s) is used to determine key biological marker levels. Information and assessments of the user's physical performance, life style and health and wellness goals is also collected and provided to an expert system that matches the biomarker levels and assessments to a knowledgebase of scientific knowledge about biomarker levels and health and fitness outcomes. Personal recommendations and advice on nutrition and exercise is then generated, which may be used to help individuals reach their diet, fitness, and wellness goals and improve their physical and mental performance and well being in measurable ways.

摘要翻译： 基于各种生物标志物和性能和生活方式评估为个人生成个性化，健康和性能计划。 在一个实施方案中，使用血液或其他生物样本的诊断测试来确定关键的生物标志物水平。 还收集了用户的身体表现，生活方式和健康和健康目标的信息和评估，并将其提供给与生物标志物水平和评估相匹配的专家系统，以及关于生物标志物水平和健康和健身结果的科学知识知识库。 然后产生关于营养和运动的个人建议和建议，这可以用于帮助个人达到他们的饮食，健身和健康目标，并以可衡量的方式改善身体和精神表现以及改善身体健康。

公开(公告)号：US20120130732A1

公开(公告)日：2012-05-24

申请号：US13190996

申请日：2011-07-26

申请人： Gil Blander ,  Christian Reich ,  David Lester

发明人： Gil Blander ,  Christian Reich ,  David Lester

IPC分类号： G06Q50/22

CPC分类号： G06F19/3475 ,  G06F19/00 ,  G06F19/10 ,  G06F19/20 ,  G06F19/24 ,  G06F19/3481 ,  G06Q10/10 ,  G06Q50/22

摘要： Personalized, health and performance programs are generated for individuals based on various biomarkers and performance and lifestyle assessments. In one embodiment, a diagnostic test of blood or other biological specimen(s) is used to determine key biological marker levels. Information and assessments of the user's physical performance, life style and health and wellness goals is also collected and provided to an expert system that matches the biomarker levels and assessments to a knowledgebase of scientific knowledge about biomarker levels and health and fitness outcomes. Personal recommendations and advice on nutrition and exercise is then generated, which may be used to help individuals reach their diet, fitness, and wellness goals and improve their physical and mental performance and well being in measurable ways.

摘要翻译： 基于各种生物标志物和性能和生活方式评估为个人生成个性化，健康和性能计划。 在一个实施方案中，使用血液或其他生物样本的诊断测试来确定关键的生物标志物水平。 还收集了用户的身体表现，生活方式和健康和健康目标的信息和评估，并将其提供给与生物标志物水平和评估相匹配的专家系统，以及关于生物标志物水平和健康和健身结果的科学知识知识库。 然后产生关于营养和运动的个人建议和建议，这可以用于帮助个人达到他们的饮食，健身和健康目标，并以可衡量的方式改善身体和精神表现以及改善身体健康。