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公开(公告)号：US4834974A
公开(公告)日：1989-05-30
申请号：US946435
申请日：1986-12-24
申请人： Gerald H. Stott , David O. Lucas
发明人： Gerald H. Stott , David O. Lucas
IPC分类号： A61K39/00 , A23C9/142 , A23J1/20 , A23K1/18 , A61K39/395 , A61P37/04 , C07K14/435 , C07K16/00 , C07K16/04
CPC分类号： A23C9/1425 , A23J1/205 , A23K50/60 , C07K16/04 , A23V2002/00 , Y10S530/833
摘要： A dry, immunologically active filtered product is produced through the controlled one or two stage ultrafiltration of liquid whey containing immunologically active immunoglobulin (Ig). When a predetermined quantity of the filtered product with an active Ig concentration of at least about seven percent of total solids is fed to newborn calves, the product functions as a substitute for natural colostrum, providing both temporary passive immunity as well as initiation of the active immune system of the animal. Disease resistance and growth rate in animals including humans is enhanced by oral administration of the filtered product. The immunological properties of the filtered product result from the presence of substantially enhanced concentrations of active Ig as well as other immunologically active whey components in comparison to the immunologically ineffective concentrations of these materials in the liquid whey ultrafiltration feedstock.
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公开(公告)号：US5198213A
公开(公告)日：1993-03-30
申请号：US777194
申请日：1991-10-16
申请人： Gerald H. Stott , David O. Lucas
发明人： Gerald H. Stott , David O. Lucas
CPC分类号： A23C9/1425 , A23J1/205 , A23K50/60 , C07K16/04 , A23V2002/00 , Y10S530/833
摘要： Whey derived from ordinary milk includes a bottom fraction including lactose and minerals, a middle fraction including lower molecular weight proteins, and a top fraction including higher molecular weight proteins. The top whey fraction includes a measurable but low level concentration of immunologically active immunoglobulin plus other pathogen specific antibodies. The whey is ultrafiltered through one or more different process steps to yield a filtered product having a concentration of immunologically active immunoglobulin of at least about seven percent of total solids. The filtered product is periodically tested to verify its activity to a specified microbe. The filtered product is orally administered in a therapeutically effective dose to an animal to treat a disease.
摘要翻译： 来自普通乳的乳清包括包含乳糖和矿物质的底部馏分，包含较低分子量蛋白质的中间馏分和包含较高分子量蛋白质的顶部馏分。 顶部乳清组分包含可测量但低水平的免疫活性免疫球蛋白加其他病原体特异性抗体浓度。 通过一个或多个不同的方法步骤对乳清进行超滤，以产生具有至少约7％的总固体的免疫活性免疫球蛋白浓度的过滤产物。 定期测试过滤产品，以验证其对指定微生物的活性。 过滤产物以治疗有效剂量口服施用于动物以治疗疾病。
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3.发明授权Method of disease treatment utilizing an immunologically active whey fraction 失效利用免疫活性乳清部分进行疾病治疗的方法
公开(公告)号：US5066491A
公开(公告)日：1991-11-19
申请号：US306817
申请日：1989-02-03
申请人： Gerald H. Stott , David O. Lucas
发明人： Gerald H. Stott , David O. Lucas
IPC分类号： A23C9/142 , A23J1/20 , A23K1/18 , C07K16/04 , A61K39/395
CPC分类号： C07K16/04 , A23C9/1425 , A23J1/205 , A23K50/60 , A23V2002/00 , Y10S530/833
摘要： Whey derived from ordinary milk includes a bottom fraction including lactose and minerals, a middle fraction including lower molecular weight proteins, and a top fraction including higher molecular weight proteins. The top whey fraction includes a measurable but low level concentration of immunologically active immunoglobulin plus other pathogen specific antibodies. The whey is ultrafiltered through one or more different process steps to yield a filtered product having a concentration of immunologically active immunoglobulin of at least about seven percent of total solids. The filtered product is periodically tested to verify its activity to a specified microbe. The filtered product is orally administered in a therapeutically effective dose to an animal to treat a disease.
摘要翻译： 来自普通乳的乳清包括包含乳糖和矿物质的底部馏分，包含较低分子量蛋白质的中间馏分和包含较高分子量蛋白质的顶部馏分。 顶部乳清组分包含可测量但低水平的免疫活性免疫球蛋白加其他病原体特异性抗体浓度。 通过一个或多个不同的方法步骤对乳清进行超滤，以产生具有至少约7％的总固体的免疫活性免疫球蛋白浓度的过滤产物。 定期测试过滤产品，以验证其对指定微生物的活性。 过滤产物以治疗有效剂量口服施用于动物以治疗疾病。
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公开(公告)号：US07202020B2
公开(公告)日：2007-04-10
申请号：US10865292
申请日：2004-06-09
CPC分类号： B01J3/04 , A01N1/021 , A01N1/0226 , A01N1/0231 , A01N1/0252 , A01N1/0257 , A01N1/0289 , B01J3/03
摘要： A platelet composition suitable for direct transfusion into a patient is provided. The platelet composition includes a preservation medium comprising plasma and a gel-forming material in a concentration relative to the plasma such that the medium is in a sufficiently fluent state at about 37° C. to allow platelets to move within the medium and is in a sufficiently gelatinous state at about 5° C. to substantially prevent platelets from moving freely within the medium; and platelets.
摘要翻译： 提供适于直接输入患者的血小板组合物。 血小板组合物包含保存介质，其包含相对于血浆浓度的等离子体和凝胶形成材料，使得介质在约37℃下处于充分流动状态，以允许血小板在培养基内移动，并且处于 在约5℃下充分凝胶状态，以基本上防止血小板在培养基内自由移动; 和血小板。
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公开(公告)号：US06828090B2
公开(公告)日：2004-12-07
申请号：US09267891
申请日：1999-03-11
IPC分类号： A01N102
CPC分类号： B01J3/04 , A01N1/021 , A01N1/0226 , A01N1/0231 , A01N1/0252 , A01N1/0257 , A01N1/0289 , B01J3/03
摘要： A platelet composition suitable for direct transfusion into a patient is provided. The platelet composition includes a preservation medium comprising plasma and a gel-forming material in a concentration relative to the plasma such that the medium is in a sufficiently fluent state at about 37° C. to allow platelets to move within the medium and is in a sufficiently gelatinous state at about 5° C. to substantially prevent platelets from moving freely within the medium; and platelets.
摘要翻译： 提供适于直接输入患者的血小板组合物。 血小板组合物包含保存介质，其包含相对于血浆浓度的等离子体和凝胶形成材料，使得介质在约37℃下处于充分流动状态，以允许血小板在培养基内移动，并且处于 在约5℃下充分凝胶状态，以基本上防止血小板在培养基内自由移动; 和血小板。
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