公开(公告)号：US11034698B2

公开(公告)日：2021-06-15

申请号：US16715933

申请日：2019-12-16

Applicant: Genentech, Inc.

Inventor： Marian C. Bryan ,  Steven Do ,  Joy Drobnick ,  Alberto Gobbi ,  Tamiko Katsumoto ,  James Richard Kiefer, Jr. ,  Jun Liang ,  Naomi S. Rajapaksa ,  Yongsheng Chen ,  Liqiang Fu ,  Kwong Wah Lai ,  Zhiguo Liu ,  John Wai ,  Fei Wang

IPC: C07D487/04 ,  C07D519/00

Abstract: Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

公开(公告)号：US20230133667A1

公开(公告)日：2023-05-04

申请号：US18047624

申请日：2022-10-18

Applicant: RQx Pharmaceuticals, Inc. ,  Genentech, Inc.

Inventor： Peter Andrew Smith ,  Tucker Curran Roberts ,  Robert I. Higuchi ,  Prasuna Paraselli ,  Michael F. T. Koehler ,  Jacob Bradley Schwarz ,  James John Crawford ,  Cuong Q. Ly ,  Emily J. Hanan ,  Huiyong Hu ,  Yongsheng Chen ,  Zhiyong Yu ,  Paul Colin Michael Winship ,  Calum MacCleod ,  Toby Blench

IPC: C07K5/11 ,  A61P31/04 ,  A61K9/00 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K45/06 ,  C07K5/083 ,  C07K5/097 ,  C07K5/107 ,  C07K7/06

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20230133817A1

公开(公告)日：2023-05-04

申请号：US18063173

申请日：2022-12-08

Applicant: RQX Pharmaceuticals, Inc. ,  Genentech, Inc.

Inventor： Yongsheng Chen ,  Peter Andrew Smith ,  Tuker Curran Roberts ,  Robert I. Higuchi ,  Prasuna Paraselli ,  Michael F.T Koehler ,  Jacob Bradley Schwarz ,  James John Crawford ,  Cuong Q. Ly ,  Emily J. Hanan ,  Huiyong Hu ,  Zhiyong Yu

IPC: C07D245/04 ,  C07K5/02 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K45/06 ,  A61K31/496 ,  A61K31/546 ,  C07K5/087 ,  C07K5/103 ,  C07K5/11 ,  C07K7/06 ,  C07K7/08 ,  C07K5/113 ,  C07K9/00 ,  C07K5/117 ,  A61K31/395 ,  A61K31/431 ,  A61K31/407 ,  A61K31/43 ,  A61K31/4196 ,  A61K31/545 ,  C07K5/09 ,  A61P31/04 ,  A61K9/00

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US11072635B2

公开(公告)日：2021-07-27

申请号：US15777509

申请日：2016-11-21

Applicant: RQX PHARMACEUTICALS, INC. ,  GENENTECH, INC.

Inventor： Yongsheng Chen ,  Peter Andrew Smith ,  Tucker Curran Roberts ,  Robert I. Higuchi ,  Prasuna Paraselli ,  Michael F. T. Koehler ,  Jacob Bradley Schwarz ,  James John Crawford ,  Cuong Q. Ly ,  Huiyong Hu ,  Zhiyong Yu

IPC: C07K7/06 ,  A61P31/04 ,  A61K9/00 ,  A61K45/06

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.