公开(公告)号：US11008403B2

公开(公告)日：2021-05-18

申请号：US15525821

申请日：2015-11-18

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan Wu ,  Eric Krauland ,  Michael Feldhaus ,  Yin Zhang ,  Joy Yu Zuchero ,  Jessica Couch ,  Mark S Dennis ,  James A Ernst ,  Gregory A Lazar

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/22 ,  A61K39/00 ,  G01N33/68

Abstract: The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.

公开(公告)号：US11542308B2

公开(公告)日：2023-01-03

申请号：US17664589

申请日：2022-05-23

Applicant: Genentech, Inc.

Inventor： Yichin Liu ,  Christine Carine Moussion ,  Travis William Bainbridge ,  Iraj Hosseini ,  Gregory Alan Lazar ,  Sivan Cohen ,  Christopher Charles Kemball ,  Jill M. Schartner

IPC: C07K14/475 ,  A61K38/18 ,  A61K31/713 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

Abstract: The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US11746160B2

公开(公告)日：2023-09-05

申请号：US17113711

申请日：2020-12-07

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan Wu ,  Eric Krauland ,  Michael Feldhaus

IPC: C12N15/52 ,  C07K16/40 ,  A61K47/68 ,  G01N33/573 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K47/6871 ,  C12N15/52 ,  C12Y304/23046 ,  G01N33/573 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  G01N2333/96472 ,  G01N2800/28 ,  G01N2800/52

Abstract: The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.

公开(公告)号：US20170362339A1

公开(公告)日：2017-12-21

申请号：US15525791

申请日：2015-11-18

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan WU ,  Eric Krauland ,  Michael Feldhaus

IPC: C07K16/40 ,  G01N33/573 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K47/6871 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C12Y304/23046 ,  G01N33/573 ,  G01N2333/96472 ,  G01N2800/28 ,  G01N2800/52

Abstract: The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.

公开(公告)号：US10882920B2

公开(公告)日：2021-01-05

申请号：US15525791

申请日：2015-11-18

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan Wu ,  Eric Krauland ,  Michael Feldhaus

IPC: C07K16/40 ,  A61K47/68 ,  A61K39/00 ,  G01N33/573

Abstract: The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.

公开(公告)号：US20180057604A1

公开(公告)日：2018-03-01

申请号：US15525821

申请日：2015-11-18

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan WU ,  Eric Krauland ,  Michael Feldhaus ,  Yin Zhang ,  Joy Yu Zuchero ,  Jessica Couch ,  Mark S Dennis ,  James A Ernst ,  Gregory A Lazar

IPC: C07K16/40 ,  C07K16/28 ,  G01N33/68

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/2881 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C12Y304/23046 ,  G01N33/6896 ,  G01N2333/70582 ,  G01N2333/96472 ,  G01N2800/28 ,  G01N2800/52

Abstract: The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.

公开(公告)号：US20210206877A1

公开(公告)日：2021-07-08

申请号：US17113711

申请日：2020-12-07

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan Wu ,  Eric Krauland ,  Michael Feldhaus

IPC: C07K16/40 ,  A61K47/68 ,  G01N33/573

Abstract: The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders