公开(公告)号：US11542308B2

公开(公告)日：2023-01-03

申请号：US17664589

申请日：2022-05-23

Applicant: Genentech, Inc.

Inventor： Yichin Liu ,  Christine Carine Moussion ,  Travis William Bainbridge ,  Iraj Hosseini ,  Gregory Alan Lazar ,  Sivan Cohen ,  Christopher Charles Kemball ,  Jill M. Schartner

IPC: C07K14/475 ,  A61K38/18 ,  A61K31/713 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

Abstract: The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US20230184747A1

公开(公告)日：2023-06-15

申请号：US18104825

申请日：2023-02-02

Applicant: GENENTECH, INC.

Inventor： Shan Chung ,  Sivan Cohen

IPC: G01N33/50 ,  C12N5/0783 ,  G01N33/68

CPC classification number: G01N33/5047 ,  C12N5/0636 ,  G01N33/6854

Abstract: The presently disclosed subject matter provides methods for determining the propensity of a composition, e.g., a composition comprising an antibody or a fragment thereof, to elicit production of anti-drug antibodies (ADAs) and kits for performing such methods.