公开(公告)号：US20140228384A1

公开(公告)日：2014-08-14

申请号：US13904922

申请日：2013-05-29

Applicant: Genentech, Inc.

Inventor： Daisy Bustos ,  Donald Kirkpatrick ,  Tracy Kleinheinz ,  John Moffat ,  Zejuan Sheng ,  Shuo Zhang ,  Haitao Zhu

IPC: G01N33/573

CPC classification number: G01N33/573 ,  G01N2333/912 ,  G01N2440/14 ,  G01N2500/04 ,  G01N2800/2835 ,  G01N2800/50 ,  G01N2800/52

Abstract: Biomarkers for screening subjects for Parkinson's disease and providing companion diagnostic tools for therapies using LRRK2 modulators, and assays for screening compounds and compositions for modulation of LRRK2 activity.

Abstract translation: 用于筛选帕金森病患者的生物标志物，并提供使用LRRK2调节剂治疗的配套诊断工具，以及筛选用于调节LRRK2活性的化合物和组合物的测定。

公开(公告)号：US12152040B2

公开(公告)日：2024-11-26

申请号：US17198240

申请日：2021-03-10

Applicant: Genentech, Inc.

Inventor： Robert Anthony Blake ,  Peter Dragovich ,  Lewis J. Gazzard ,  Susan Kaufman ,  Tracy Kleinheinz ,  Thomas Pillow ,  Steven T. Staben ,  Binqing Wei

IPC: C07D495/14 ,  A61P35/00 ,  C07D495/16

Abstract: The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.