![Tert-butyl (s)-2-(4-(phenyl)-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain BRD4 inhibitors for treating cancer](/docs/US/2024-11-26/US12152040B2/abs.jpg.600x600.jpg)
- Patent Title: Tert-butyl (s)-2-(4-(phenyl)-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain BRD4 inhibitors for treating cancer
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Application No.: US17198240Application Date: 2021-03-10
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Publication No.: US12152040B2Publication Date: 2024-11-26
- Inventor: Robert Anthony Blake , Peter Dragovich , Lewis J. Gazzard , Susan Kaufman , Tracy Kleinheinz , Thomas Pillow , Steven T. Staben , Binqing Wei
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07D495/14
- IPC: C07D495/14 ; A61P35/00 ; C07D495/16
![Tert-butyl (s)-2-(4-(phenyl)-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain BRD4 inhibitors for treating cancer](/abs-image/US/2024/11/26/US12152040B2/abs.jpg.150x150.jpg)
Abstract:
The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
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