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![Tert-butyl (s)-2-(4-(phenyl)-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain BRD4 inhibitors for treating cancer](/abs-image/US/2024/11/26/US12152040B2/abs.jpg.150x150.jpg)
公开(公告)号：US12152040B2
公开(公告)日：2024-11-26
申请号：US17198240
申请日：2021-03-10
Applicant: Genentech, Inc.
Inventor： Robert Anthony Blake , Peter Dragovich , Lewis J. Gazzard , Susan Kaufman , Tracy Kleinheinz , Thomas Pillow , Steven T. Staben , Binqing Wei
IPC: C07D495/14 , A61P35/00 , C07D495/16
Abstract: The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
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