公开(公告)号：US20040241703A1

公开(公告)日：2004-12-02

申请号：US10643795

申请日：2003-08-19

Applicant: GENENTECH, INC.

Inventor： Frederic J. DeSauvage ,  Gretchen Frantz ,  Kenneth J. Hillan ,  Paul Polakis ,  Andrew Polson ,  Victoria Smith ,  Susan D. Spencer ,  Thomas D. Wu ,  Zemin Zhang

IPC: C12Q001/68 ,  C07H021/04 ,  C07K016/44 ,  C12N005/06

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20020161199A1

公开(公告)日：2002-10-31

申请号：US09938418

申请日：2001-08-23

Applicant: GENENTECH, INC.

Inventor： Avi Ashkenazi ,  Audrey Goddard ,  Paul J. Godowski ,  Austin Gurney ,  Paul Polakis ,  P. Mickey Williams ,  William I. Wood ,  Thomas D. Wu ,  Zemin Zhang

IPC: C07K016/46 ,  C07K016/30

CPC classification number: C07K14/705

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US20030228305A1

公开(公告)日：2003-12-11

申请号：US10331496

申请日：2002-12-30

Applicant: GENENTECH, INC.

Inventor： Gretchen Frantz ,  Kenneth J. Hillan ,  Heidi S. Phillips ,  Paul Polakis ,  Victoria Smith ,  Susan D. Spencer ,  P. Mickey Williams ,  Thomas D. Wu ,  Zemin Zhang

IPC: A61K039/395 ,  C07K016/44

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K51/1018 ,  A61K51/1045 ,  A61K2039/505 ,  C07K16/18

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20030148408A1

公开(公告)日：2003-08-07

申请号：US10241220

申请日：2002-09-11

Applicant: GENENTECH, INC.

Inventor： Gretchen Frantz ,  Kenneth J. Hillan ,  Heidi Phillips ,  Paul Polakis ,  Susan D. Spencer ,  P. Mickey Williams ,  Thomas D. Wu ,  Zemin Zhang

IPC: G01N033/574 ,  C07K016/30

CPC classification number: C07K14/4748 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/71 ,  C07K16/18 ,  C07K16/30 ,  G01N33/574

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20030060612A1

公开(公告)日：2003-03-27

申请号：US09888257

申请日：2001-06-22

Applicant: GENENTECH, INC.

Inventor： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Paul Polakis ,  Victoria Smith ,  William I. Wood ,  Thomas D. Wu ,  Zemin Zhang

IPC: C07H021/02 ,  C07H021/04

CPC classification number: C07K14/4748 ,  A61K38/00 ,  C07K2319/30

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20040258678A1

公开(公告)日：2004-12-23

申请号：US10370715

申请日：2003-02-21

Applicant: Genentech, Inc.

Inventor： Sarah C. Bodary ,  Hilary Clark ,  Brisdell Hunte ,  Janet K. Jackman ,  Jill R. Schoenfeld ,  P. Mickey Williams ,  William I. Wood ,  Thomas D. Wu

IPC: A61K039/395 ,  C07H021/04 ,  C12N009/00

CPC classification number: G01N33/564 ,  A61K38/00 ,  C07K14/47

Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

公开(公告)号：US20040126807A1

公开(公告)日：2004-07-01

申请号：US10758377

申请日：2004-01-15

Applicant: Genentech, Inc.

Inventor： Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Paul Polakis ,  Victoria Smith ,  William I. Wood ,  Thomas D. Wu ,  Zemin Zhang

IPC: C12Q001/68 ,  C07H021/04 ,  A61K039/395 ,  C07K014/47 ,  C07K016/30

CPC classification number: C07K14/705 ,  A61K47/6455 ,  C07K16/30 ,  C07K16/40 ,  C12N9/0091

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20040009171A1

公开(公告)日：2004-01-15

申请号：US10372683

申请日：2003-02-21

Applicant: GENENTECH, INC.

Inventor： Mary E. Gerritsen ,  Franklin V. Peale JR. ,  Thomas D. Wu

IPC: A61K039/395 ,  C07K016/18

CPC classification number: G01N33/57438 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/82 ,  C07K16/30 ,  C07K16/3076 ,  G01N33/57484 ,  G01N2333/726 ,  G01N2500/00

Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.

Abstract translation: 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞如肾细胞癌基因组中扩增的基因的鉴定。 预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是某些癌症如肾细胞癌的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 本发明涉及新型的诊断和治疗肿瘤的方法，例如肾细胞癌或Wilms肿瘤。

公开(公告)号：US20040229277A1

公开(公告)日：2004-11-18

申请号：US10872972

申请日：2004-06-21

Applicant: Genentech, Inc.

Inventor： Gretchen Frantz ,  Kenneth J. Hillan ,  Heidi Phillips ,  Paul Polakis ,  Susan D. Spencer ,  P. Mickey Williams ,  Thomas D. Wu ,  Zemin Zhang

IPC: C12Q001/68 ,  G01N033/574 ,  A61K038/17 ,  C07K014/705

CPC classification number: C07K14/4748 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/71 ,  C07K16/18 ,  C07K16/30 ,  G01N33/574

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20030228319A1

公开(公告)日：2003-12-11

申请号：US10411010

申请日：2003-04-10

Applicant: Genentech, Inc.

Inventor： Gretchen Frantz ,  Paul Polakis ,  Susan D. Spencer ,  Thomas D. Wu ,  Zemin Zhang

IPC: A61K039/395 ,  G01N033/574 ,  C07K016/46 ,  C07K016/30

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2803 ,  C12N2799/026

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.