公开(公告)号：US20040121370A1

公开(公告)日：2004-06-24

申请号：US10658482

申请日：2003-09-09

Applicant: Genentech, Inc.

Inventor： Daryl T. Baldwin ,  Sarah C. Bodary ,  Andrew C. Chan ,  Hilary Clark ,  Janet K. Jackman ,  William I. Wood

IPC: C12Q001/68 ,  C07H021/04 ,  C07K014/47 ,  C07K016/18 ,  C12P021/02 ,  C12N001/21 ,  C12N001/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C12N2799/026 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2500/10 ,  G01N2800/065 ,  G01N2800/205 ,  G01N2800/24

Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Abstract translation: 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。

公开(公告)号：US20040258678A1

公开(公告)日：2004-12-23

申请号：US10370715

申请日：2003-02-21

Applicant: Genentech, Inc.

Inventor： Sarah C. Bodary ,  Hilary Clark ,  Brisdell Hunte ,  Janet K. Jackman ,  Jill R. Schoenfeld ,  P. Mickey Williams ,  William I. Wood ,  Thomas D. Wu

IPC: A61K039/395 ,  C07H021/04 ,  C12N009/00

CPC classification number: G01N33/564 ,  A61K38/00 ,  C07K14/47

Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

公开(公告)号：US20030113764A1

公开(公告)日：2003-06-19

申请号：US10226844

申请日：2002-08-22

Applicant: Genentech, Inc.

Inventor： Sarah C. Bodary ,  Karen L. Fisher

IPC: C12Q001/68 ,  G01N033/574 ,  A61K039/395 ,  C12N009/64 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K14/70596 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2896 ,  C12N2799/026

Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of an ADAM8 gene that is amplified in the genome of tumor cells. Such gene amplification is associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contributes to tumorigenesis. Accordingly, the ADAM8 protein encoded by the amplified gene is a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and acts as a predictor of the prognosis of tumor treatment.

Abstract translation: 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的ADAM8基因的鉴定。 与相同组织类型的正常细胞相比，这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的ADAM8蛋白是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且作为肿瘤治疗预后的预测因子。