公开(公告)号：US20040033949A1

公开(公告)日：2004-02-19

申请号：US10431105

申请日：2003-05-06

Applicant: GENENTECH, INC.

Inventor： Stuart Bunting ,  Richard Carano ,  Ellen Hope Filvaroff ,  Richard Andre Gosselin ,  Franklin V. Peale JR.

IPC: A61K038/18 ,  A61K009/22

CPC classification number: A61K9/0024 ,  A61K38/1866 ,  A61K38/1875 ,  A61L27/18 ,  A61L27/227 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2430/02 ,  C08L67/04 ,  A61K2300/00

Abstract: The present invention provides pharmaceutical compositions comprising VEGF or variants thereof for promoting bone formation, in vitro and in vivo. Methods of using those compositions are also provided. Compositions and methods of the present invention can be used for promoting and improving the repair process in subjects with bone defects.

Abstract translation: 本发明提供了包含VEGF或其变体的药物组合物，用于在体外和体内促进骨形成。 还提供了使用这些组合物的方法。 本发明的组合物和方法可用于促进和改善具有骨缺损的受试者的修复过程。

公开(公告)号：US20040009171A1

公开(公告)日：2004-01-15

申请号：US10372683

申请日：2003-02-21

Applicant: GENENTECH, INC.

Inventor： Mary E. Gerritsen ,  Franklin V. Peale JR. ,  Thomas D. Wu

IPC: A61K039/395 ,  C07K016/18

CPC classification number: G01N33/57438 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/82 ,  C07K16/30 ,  C07K16/3076 ,  G01N33/57484 ,  G01N2333/726 ,  G01N2500/00

Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.

Abstract translation: 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞如肾细胞癌基因组中扩增的基因的鉴定。 预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是某些癌症如肾细胞癌的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 本发明涉及新型的诊断和治疗肿瘤的方法，例如肾细胞癌或Wilms肿瘤。