公开(公告)号：US20240239766A1

公开(公告)日：2024-07-18

申请号：US18584298

申请日：2024-02-22

申请人： Genentech, Inc.

发明人： Steven John MCKERRALL ,  Daniel Fred ORTWINE ,  Philippe BERGERON ,  Ramsay BEVERIDGE ,  Elise GHIRO ,  Kwong Wah LAI ,  Guqin SHI

IPC分类号： C07D401/12 ,  A61K31/454 ,  A61K31/506 ,  A61P17/04 ,  A61P29/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D401/12 ,  A61K31/454 ,  A61K31/506 ,  A61P17/04 ,  A61P29/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

摘要： The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Z1, Z2, R3-R8, RA, ring A, and n have the meanings described herein, and compositions containing such compounds and methods for using such compounds and compositions for the treatment of pain.

公开(公告)号：US20190263786A1

公开(公告)日：2019-08-29

申请号：US16283451

申请日：2019-02-22

申请人： GENENTECH, INC.

发明人： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Kwong Wah LAI ,  Zhiguo LIU ,  Wenfeng LIU ,  Ramsay BEVERIDGE ,  Jean-Philippe LECLERC ,  Alexandre LEMIRE ,  Liang ZHAO ,  Claudio STURINO

IPC分类号： C07D403/12 ,  C07D233/96 ,  C07D401/12 ,  C07D401/14 ,  C07D263/52 ,  C07D305/06 ,  A61P17/04

摘要： The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20210253597A1

公开(公告)日：2021-08-19

申请号：US17153536

申请日：2021-01-20

申请人： GENENTECH, INC.

发明人： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC分类号： C07D498/04 ,  C07D471/04 ,  A61P11/00 ,  A61P9/00 ,  A61P25/24 ,  A61P25/00 ,  A61P29/00

摘要： The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20210214336A1

公开(公告)日：2021-07-15

申请号：US17056325

申请日：2019-05-21

申请人： GENENTECH, INC.

发明人： Steven MCKERRALL ,  Ramsay BEVERIDGE ,  Kwong Wah LAI ,  Philippe BERGERON

IPC分类号： C07D401/12 ,  A61P17/04 ,  A61K9/00 ,  A61P29/00

摘要： The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y1-Y6, X, Z, Z1, Z2, R2-R3, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain

公开(公告)号：US20210107895A1

公开(公告)日：2021-04-15

申请号：US17031492

申请日：2020-09-24

申请人： GENENTECH, INC.

发明人： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Kwong Wah LAI

IPC分类号： C07D401/14

摘要： The invention provides a compounds and salts that are sodium channel modulators, as well as compositions containing such a compound or salt and therapeutic methods for using such a compound, salt, or composition.

公开(公告)号：US20210171516A1

公开(公告)日：2021-06-10

申请号：US17031348

申请日：2020-09-24

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Philippe BERGERON ,  Kristen BURFORD ,  Sultan CHOWDHURY ,  Christoph Martin DEHNHARDT ,  Thilo FOCKEN ,  Michael Edward GRIMWOOD ,  Abid HASAN ,  Kwong Wah LAI ,  Zhiguo LIU ,  Steven MCKERRALL ,  Teresa Phuongtram NGUYEN ,  Brian Salvatore SAFINA ,  Daniel SUTHERLIN ,  Tao WANG

IPC分类号： C07D417/12 ,  C07D417/14 ,  A61P17/04 ,  C07D401/12 ,  C07D405/14 ,  C07D491/107

摘要： The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20190300544A1

公开(公告)日：2019-10-03

申请号：US16370756

申请日：2019-03-29

申请人： GENENTECH, INC.

发明人： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC分类号： C07D498/04 ,  C07D471/04 ,  A61P25/24 ,  A61P9/00 ,  A61P11/00

摘要： The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20180105504A1

公开(公告)日：2018-04-19

申请号：US15799771

申请日：2017-10-31

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Michael Scott WILSON ,  Kwong Wah LAI ,  Philippe BERGERON ,  Birong ZHANG

IPC分类号： C07D277/52 ,  C07D239/69 ,  C07D285/08 ,  C07D417/12 ,  C07D213/76 ,  C07D401/12 ,  C07D403/12 ,  C07D261/16

CPC分类号： C07D277/52 ,  A61K31/427 ,  A61P19/02 ,  A61P29/00 ,  C07D213/76 ,  C07D239/69 ,  C07D261/16 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

摘要： The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1-Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20230159555A1

公开(公告)日：2023-05-25

申请号：US17814115

申请日：2022-07-21

申请人： Genentech, Inc.

发明人： Paul GIBBONS ,  Kwong Wah LAI ,  Christian NILEWSKI ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Bing-Yan ZHU ,  Huifen CHEN

IPC分类号： C07D498/04

CPC分类号： C07D498/04

摘要： Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B),




solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

公开(公告)号：US20220081423A1

公开(公告)日：2022-03-17

申请号：US17331164

申请日：2021-05-26

申请人： GENENTECH, INC.

发明人： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Kwong Wah LAI ,  Zhiguo LIU ,  Wenfeng LIU ,  Ramsay BEVERIDGE ,  Jean-Philippe LECLERC ,  Alexandre LEMIRE ,  Liang ZHAO ,  Claudio STURINO

IPC分类号： C07D403/12 ,  C07D233/96 ,  C07D401/12 ,  A61P17/04 ,  C07D263/52 ,  C07D305/06 ,  C07D401/14 ,  A61K31/506 ,  A61K31/538 ,  C07D413/12 ,  C07B59/00 ,  A61K31/63 ,  A61K45/06 ,  C07D239/69 ,  A61K31/505

摘要： The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative: