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公开(公告)号：US20190263786A1
公开(公告)日：2019-08-29
申请号：US16283451
申请日：2019-02-22
Applicant: GENENTECH, INC.
Inventor： Daniel SUTHERLIN , Steven MCKERRALL , Kwong Wah LAI , Zhiguo LIU , Wenfeng LIU , Ramsay BEVERIDGE , Jean-Philippe LECLERC , Alexandre LEMIRE , Liang ZHAO , Claudio STURINO
IPC: C07D403/12 , C07D233/96 , C07D401/12 , C07D401/14 , C07D263/52 , C07D305/06 , A61P17/04
Abstract: The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20170087136A1
公开(公告)日：2017-03-30
申请号：US15275131
申请日：2016-09-23
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: A61K31/445 , A61K31/4545 , A61K31/4523
CPC classification number: A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variablesRA, RAA, subscipt n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20150252038A1
公开(公告)日：2015-09-10
申请号：US14603273
申请日：2015-01-22
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: C07D453/02 , C07D205/04 , C07D401/06 , C07D403/12 , C07D401/12 , C07D211/42
CPC classification number: A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compactions.
Abstract translation: 本发明提供具有通式I的化合物及其药学上可接受的盐，其中变量RA，RAA，下标n，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5和RN 具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
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Patent Agency Ranking
公开(公告)号：US20210171516A1
公开(公告)日：2021-06-10
申请号：US17031348
申请日：2020-09-24
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Philippe BERGERON , Kristen BURFORD , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Abid HASAN , Kwong Wah LAI , Zhiguo LIU , Steven MCKERRALL , Teresa Phuongtram NGUYEN , Brian Salvatore SAFINA , Daniel SUTHERLIN , Tao WANG
IPC: C07D417/12 , C07D417/14 , A61P17/04 , C07D401/12 , C07D405/14 , C07D491/107
Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20210093618A1
公开(公告)日：2021-04-01
申请号：US16677487
申请日：2019-11-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian Salvatore SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: A61K31/445 , C07D295/26 , A61K31/4015 , C07D211/22 , C07D233/68 , C07D305/08 , C07D205/12 , A61K31/4523 , C07D405/12 , C07D413/06 , C07D451/02 , C07D405/04 , C07D211/54 , C07D403/12 , C07D487/08 , C07D237/08 , C07D205/04 , C07D211/32 , A61K31/4412 , A61K31/415 , C07D401/04 , A61K31/337 , A61K31/495 , C07D211/60 , A61K31/4545 , C07D403/04 , C07D413/12 , C07D401/12 , C07D265/30 , C07D417/06 , C07D451/06 , C07D211/42 , A61K31/397 , C07F7/08 , C07D211/96 , C07D241/04 , C07D401/06 , C07D453/02 , C07D207/12 , C07D295/155
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20220081423A1
公开(公告)日：2022-03-17
申请号：US17331164
申请日：2021-05-26
Applicant: GENENTECH, INC.
Inventor： Daniel SUTHERLIN , Steven MCKERRALL , Kwong Wah LAI , Zhiguo LIU , Wenfeng LIU , Ramsay BEVERIDGE , Jean-Philippe LECLERC , Alexandre LEMIRE , Liang ZHAO , Claudio STURINO
IPC: C07D403/12 , C07D233/96 , C07D401/12 , A61P17/04 , C07D263/52 , C07D305/06 , C07D401/14 , A61K31/506 , A61K31/538 , C07D413/12 , C07B59/00 , A61K31/63 , A61K45/06 , C07D239/69 , A61K31/505
Abstract: The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative:
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公开(公告)号：US20180291014A1
公开(公告)日：2018-10-11
申请号：US15939112
申请日：2018-03-28
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Phillipe BERGERON , Kristen BURFORD , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Abid HASAN , Kwong Wah LAI , Zhiguo LIU , Steven MCKERRALL , Teresa Phuongtram NGUYEN , Brian SAFINA , Daniel SUTHERLIN , Tao WANG
IPC: C07D417/12 , C07D417/14 , C07D401/12 , C07D405/14 , C07D491/107 , A61P17/04
Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20160340309A1
公开(公告)日：2016-11-24
申请号：US15161085
申请日：2016-05-20
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Abid HASAN , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian SAFINA , Daniel SUTHERLIN , Shaoyi SUN , Andrew D. WHITE , Wei GONG , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: C07D211/22 , C07D211/34 , C07D405/08 , C07D401/04 , C07D401/08 , C07D211/42 , C07D221/20 , C07D211/48 , C07D401/12
CPC classification number: C07D211/22 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/48 , C07D211/62 , C07D221/20 , C07D401/04 , C07D401/08 , C07D401/12 , C07D405/08
Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供了具有钠通道活性的化合物（例如，NaV1.7）抑制剂，其可用于治疗钠通道介导的疾病或病症，例如疼痛，以及与钠通道调停相关的其它疾病和病症，以及 含有这些化合物的组合物和使用这些化合物和组合物的方法。
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