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公开(公告)号：US20180258043A1
公开(公告)日：2018-09-13
申请号：US15914351
申请日：2018-03-07
Applicant: GENENTECH, INC. , CURIS, INC.
Inventor： Janet L. GUNZNER-TOSTE , Daniel P. SUTHERLIN , Mark S. STANLEY , Liang BAO , Georgette M. CASTANEDO , Rebecca L. LALONDE , Shumei WANG , Mark E. REYNOLDS , Scott J. SAVAGE , Kimberly MALESKY , Michael S. DINA , Michael F.T. KOEHLER
IPC: C07D213/16 , C07F9/58 , C07D417/04 , C07D413/14 , C07D213/56 , C07D417/14 , C07D213/06 , C07D413/12 , C07D409/12 , C07D405/12 , C07D401/14 , C07D401/12 , C07D417/12
CPC classification number: C07D213/16 , C07D213/06 , C07D213/56 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/58
Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
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公开(公告)号：US20230265054A1
公开(公告)日：2023-08-24
申请号：US18119887
申请日：2023-03-10
Applicant: GENENTECH, INC. , CURIS, INC.
Inventor： Janet L. GUNZNER-TOSTE , Daniel P. SUTHERLIN , Mark S. STANLEY , Liang BAO , Georgette M. CASTANEDO , Rebecca L. LALONDE , Shumei WANG , Mark E. REYNOLDS , Scott J. SAVAGE , Kimberly MALESKY , Michael S. DINA , Michael F.T. KOEHLER
IPC: C07D213/82 , C07D213/40 , C07D409/12 , C07D413/12 , C07D401/12 , C07D401/14 , C07D417/04 , C07D213/56 , C07D213/38 , C07D213/74 , C07D417/12 , C07D405/12 , C07D213/81 , C07D213/71
CPC classification number: C07D213/82 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/71 , C07D213/74 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12
Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I:
wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.-
公开(公告)号：US20150322002A1
公开(公告)日：2015-11-12
申请号：US14413218
申请日：2013-07-05
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Christoph Martin DEHNHARDT , Sultan CHOWDHURY , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Brian SAFINA , Daniel P. SUTHERLIN
IPC: C07C307/06 , C07D205/04 , C07D217/02 , C07D413/12 , C07D277/24 , C07D209/08 , C07D213/69 , C07D401/12
CPC classification number: C07C307/06 , C07C2601/04 , C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, ring D, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract translation: 本发明提供具有通式（I）的新化合物及其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，环D，R1和RN具有如上所述的含义 和含有这些化合物的组合物和使用这些化合物和组合物的方法。
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Patent Agency Ranking
公开(公告)号：US20250064968A1
公开(公告)日：2025-02-27
申请号：US18784386
申请日：2024-07-25
Applicant: Genentech, Inc.
Inventor： Daniel P. SUTHERLIN , Donglu ZHANG , Summer A. BAKER DOCKERY , Peter Scott DRAGOVICH
IPC: A61K47/68
Abstract: The subject matter described herein relates generally to hydrolysable maleimide-containing molecules that are useful as linkers to covalently bind chemical inducers of degradation to antibodies and to the conjugates produced therefrom and their uses to treat conditions, and to the uses of the conjugates in treating diseases and conditions where targeted protein degradation is beneficial.
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公开(公告)号：US20170015627A1
公开(公告)日：2017-01-19
申请号：US15221958
申请日：2016-07-28
Applicant: GENENTECH, INC. , CURIS, INC.
Inventor： Janet L. GUNZNER-TOSTE , Daniel P. SUTHERLIN , Mark S. STANLEY , Liang BAO , Georgette M. CASTANEDO , Rebecca L. LALONDE , Shumei WANG , Mark E. REYNOLDS , Scott J. SAVAGE , Kimberly MALESKY , Michael S. DINA , Michael F.T. KOEHLER
IPC: C07D213/16 , C07D401/14 , C07D409/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07F9/58 , C07D401/12 , C07D413/12
CPC classification number: C07D213/16 , C07D213/06 , C07D213/56 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/58
Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
Abstract translation: 其中A，X，Y R1，R2，R3，R4，m和n如本文所述。
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公开(公告)号：US20250073345A1
公开(公告)日：2025-03-06
申请号：US18784398
申请日：2024-07-25
Applicant: Genentech, Inc.
Inventor： Daniel P. SUTHERLIN , Donglu ZHANG , Summer A. BAKER DOCKERY , Peter Scott DRAGOVICH
IPC: A61K47/68
Abstract: The subject matter described herein is directed to molecules referred to herein as chemical inducers of degradation (CIDEs) and antibody-conjugated CIDEs (Ab-CIDEs), wherein the Ab-CIDEs comprise an antibody covalently bound to the CIDE through a linker, wherein the CIDE can be further covalently bound to a phosphate moiety, and to the uses of the molecules in treating diseases and conditions where targeted protein degradation is beneficial.
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公开(公告)号：US20180346416A1
公开(公告)日：2018-12-06
申请号：US16057693
申请日：2018-08-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Christoph Martin DEHNHARDT , Sultan CHOWDHURY , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Brian Salvatore SAFINA , Daniel P. SUTHERLIN
IPC: C07C307/06 , C07D277/24 , C07D401/12 , C07D305/08 , C07D213/64 , C07D213/63 , C07D277/62 , C07D277/34 , C07D405/12 , C07D231/56 , C07D215/20 , C07D213/74 , C07D213/69 , C07D209/08 , C07D205/04 , C07D413/12 , C07D217/02
CPC classification number: C07C307/06 , C07C2601/04 , C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: The invention provides methods for treating pain using compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, ring D, R1, and RN have the meaning as described herein.
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公开(公告)号：US20150111879A1
公开(公告)日：2015-04-23
申请号：US14582268
申请日：2014-12-24
Applicant: GENENTECH, INC. , CURIS, INC.
Inventor： Janet L. GUNZNER , Daniel P. SUTHERLIN , Mark S. STANLEY , Liang BAO , Georgette M. CASTANEDO , Rebecca L. LALONDE , Shumei WANG , Mark E. REYNOLDS , Scott J. SAVAGE , Kimberly MALESKY , Michael S. DINA , Michael F.T. KOEHLER
IPC: C07D413/14 , C07D413/12 , C07D213/56 , C07D409/12 , C07D401/12 , C07D401/14
CPC classification number: C07D213/16 , C07D213/06 , C07D213/56 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/58
Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
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