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    Robotic autosampler for automated electrospray from a microfluidic chip
    1.
    发明申请
    Robotic autosampler for automated electrospray from a microfluidic chip 审中-公开
    用于微流控芯片自动电喷雾的机器人自动进样器

    公开(公告)号：US20050145787A1

    公开(公告)日：2005-07-07

    申请号：US11054165

    申请日：2005-02-09

    Applicant: Simon Prosser ,  Geoffrey Rule ,  Gary Schultz ,  Thomas Corso

    Inventor： Simon Prosser ,  Geoffrey Rule ,  Gary Schultz ,  Thomas Corso

    IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    CPC classification number: G01N35/10 ,  G01N35/0099 ,  G01N35/04 ,  G01N2035/00158 ,  G01N2035/0491 ,  G01N2035/1034 ,  H01J49/0413 ,  H01J49/165

    Abstract: A robotic autosampler provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets for interface to a mass spectrometer or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays in communication with a detector, includes: providing a robot autosampler having an electrospray chip; electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

    Abstract translation: 机器人自动进样器提供具有多个电喷雾装置和/或用于与质谱仪或其他检测装置接口的样品入口的微流体芯片的自动操作。 自动进样器还提供了将控制电压连接到电喷雾装置，以便于带电液滴和离子的启用，控制和转向。 自动进样器还提供可以是一次性的或可重复使用的流体输送方法。 输送装置可以含有用于组分分离或样品纯化的材料。 输送装置可以包含预加载的样品，或者样品可以由自动进样器装载。 一种用于自动操作与检测器通信的多个电喷雾的方法，包括：提供具有电喷雾芯片的机器人自动进样器; 从电喷雾芯片上的至少一个电喷雾装置电喷雾至少一种分析物; 以及以检测来自电喷雾的分析物的方式操纵与检测器通信的电喷雾芯片。

    Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
    2.
    发明申请
    Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method 审中-公开
    集成的单片微型配料喷嘴和液相色谱 - 电喷雾系统及方法

    公开(公告)号：US20050006502A1

    公开(公告)日：2005-01-13

    申请号：US10813866

    申请日：2004-03-31

    Applicant: Gary Schultz ,  Thomas Corso

    Inventor： Gary Schultz ,  Thomas Corso

    IPC: G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  B05B5/00

    CPC classification number: H01J49/167 ,  G01N30/6095 ,  G01N30/7266 ,  H01J49/0018

    Abstract: A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate droplets or an electrospray. A plurality of these electrospray devices can be used in the form of an array of miniaturized nozzles. The liquid chromatography-electrospray device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow. A cover substrate is bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate. The exit orifice of the liquid chromatography device is homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. Procedures for fabrication of the electrospray devices of the present invention are also disclosed.

    Abstract translation: 公开了液滴/电喷雾装置和液相色谱 - 电喷雾系统。 液滴/电喷雾装置包括限定喷射表面上的入口和喷射表面上的出口之间的通道的基底，由从出射孔周围的喷射表面凹陷的部分限定的喷嘴，以及用于施加 对基板的电位以优化和产生液滴或电喷雾。 多个这样的电喷雾装置可以以小型化喷嘴阵列的形式使用。 液相色谱 - 电喷雾装置包括分隔衬底，其限定了入口孔和储存器之间的引入通道以及储存器和出口孔之间的分离通道，分离通道具有垂直于流体流动的分离柱。 覆盖基板被结合到分离基板以封闭储存器和邻近盖基板的分离通道。 液相色谱装置的出口与电喷雾装置的入口孔均匀地接合，形成一个集成的单一系统。 还公开了用于制造本发明的电喷雾装置的步骤。

    Occluding Earbud System and Method
    4.
    发明申请
    Occluding Earbud System and Method 审中-公开
    封闭耳塞系统和方法

    公开(公告)号：US20090202098A1

    公开(公告)日：2009-08-13

    申请号：US12030395

    申请日：2008-02-13

    Applicant: Eric Chan ,  Diane Elabidi ,  Bernice Cramer ,  Gary Schultz

    Inventor： Eric Chan ,  Diane Elabidi ,  Bernice Cramer ,  Gary Schultz

    IPC: H04R25/00

    CPC classification number: H04R1/1066

    Abstract: An earbud is disclosed for use in a user's ear. The earbud includes an ear pad shaped to engage the concha of the ear and an audio driver coupled to the ear pad. When the earbud is installed in the user's ear the ear pad substantially occludes, or closes up the concha of the user's ear. Thus ambient noise is significantly attenuated before reaching the user's ear canal. Also, the earbud is supported primarily by the ear pad resting in the concha.

    Abstract translation: 耳塞被公开用于用户的耳朵。 耳塞包括形成为接合耳朵的耳朵的耳垫和耦合到耳垫的音频驱动器。 当耳塞安装在用户的耳朵中时，耳垫基本上封闭，或闭合用户耳朵的耳朵。 因此，环境噪声在到达用户的耳道之前被显着衰减。 此外，耳塞主要由支撑在耳塞上的耳垫支撑。

    ADAPTIVE SYNCHRONOUS PROTOCOL FOR MINIMIZING LATENCY IN TDD SYSTEMS
    5.
    发明申请
    ADAPTIVE SYNCHRONOUS PROTOCOL FOR MINIMIZING LATENCY IN TDD SYSTEMS 有权
    用于在TDD系统中最小化延迟的自适应同步协议

    公开(公告)号：US20130051286A1

    公开(公告)日：2013-02-28

    申请号：US13217428

    申请日：2011-08-25

    Applicant: Gary Schultz ,  Paul Odlyzko

    Inventor： Gary Schultz ,  Paul Odlyzko

    IPC: H04W56/00 ,  H04B7/005

    CPC classification number: H04L7/04 ,  H04L5/1469 ,  H04L5/1476 ,  H04W56/0015

    Abstract: Systems and methods are presented that offer significant improvements in the performance of time division duplex (TDD) systems by utilizing an adaptive synchronous protocol. Conventional TDD systems are limited because data is transmitted during discreet and limited intervals of time, and because TDD transceivers may not simultaneously transmit and receive for reasons of insufficiently separated frequencies and limited receiver selectivity. Typically, TDD systems have significant latency due to the time to change from transmission to reception and the propagation delay time. By synchronizing the master nodes and the one or more remotes and by scheduling the traffic loads between these nodes, remote nodes may begin transmitting before the master node is finished with its transmission, and vice versa. This method reduces latency and improves the frame efficiency. Further, the frame efficiency may improve as the distance from the master node to the remote node increases.

    Abstract translation: 提出了通过利用自适应同步协议提供时分双工（TDD）系统的性能的显着改进的系统和方法。 传统的TDD系统是受限制的，因为在谨慎和有限的时间间隔期间传输数据，并且由于TDD收发器可能不会同时发送和接收，原因是分离频率不足和接收机选择性受限。 通常，由于从传输到接收的时间和传播延迟时间的改变，TDD系统具有显着的延迟。 通过同步主节点和一个或多个遥控器，并通过调度这些节点之间的业务负载，远程节点可以在主节点完成传输之前开始发送，反之亦然。 该方法减少了延迟并提高了帧效率。 此外，随着从主节点到远程节点的距离的增加，帧效率可以改善。

    Adaptive synchronous protocol for minimizing latency in TDD systems
    8.
    发明授权
    Adaptive synchronous protocol for minimizing latency in TDD systems 有权
    自适应同步协议，用于最小化TDD系统中的延迟

    公开(公告)号：US09247512B2

    公开(公告)日：2016-01-26

    申请号：US13217428

    申请日：2011-08-25

    Applicant: Gary Schultz ,  Paul Odlyzko

    Inventor： Gary Schultz ,  Paul Odlyzko

    IPC: H04L12/28 ,  H04W56/00 ,  H04J1/16

    CPC classification number: H04L7/04 ,  H04L5/1469 ,  H04L5/1476 ,  H04W56/0015

    Abstract: Systems and methods are presented that offer significant improvements in the performance of time division duplex (TDD) systems by utilizing an adaptive synchronous protocol. Conventional TDD systems are limited because data is transmitted during discreet and limited intervals of time, and because TDD transceivers may not simultaneously transmit and receive for reasons of insufficiently separated frequencies and limited receiver selectivity. Typically, TDD systems have significant latency due to the time to change from transmission to reception and the propagation delay time. By synchronizing the master nodes and the one or more remotes and by scheduling the traffic loads between these nodes, remote nodes may begin transmitting before the master node is finished with its transmission, and vice versa. This method reduces latency and improves the frame efficiency. Further, the frame efficiency may improve as the distance from the master node to the remote node increases.

    Abstract translation: 提出了通过利用自适应同步协议提供时分双工（TDD）系统的性能的显着改进的系统和方法。 传统的TDD系统是受限制的，因为在谨慎和有限的时间间隔期间传输数据，并且因为TDD收发器可能不会同时发送和接收，原因是分离频率不足和接收机选择性受限。 通常，由于从传输到接收的时间和传播延迟时间的改变，TDD系统具有显着的延迟。 通过同步主节点和一个或多个遥控器，并通过调度这些节点之间的业务负载，远程节点可以在主节点完成传输之前开始发送，反之亦然。 该方法减少了延迟并提高了帧效率。 此外，随着从主节点到远程节点的距离的增加，帧效率可以改善。

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