公开(公告)号：US20150141283A1

公开(公告)日：2015-05-21

申请号：US14489167

申请日：2014-09-17

Applicant: GENENTECH, INC.

Inventor： Jian CHEN ,  Ellen FILVAROFF ,  Sherman FONG ,  Dorothy FRENCH ,  Audrey GODDARD ,  Paul J. GODOWSKI ,  J. Christopher GRIMALDI ,  Austin L. GURNEY ,  Kenneth J. HILIAN ,  Sarah G. HYMOWITZ ,  Hanzhong LI ,  Melissa A. STAROVASNIK ,  Daniel TUMAS ,  Menno VAN LOOKEREN ,  Richard VANDLEN ,  Colin K. WATANABE ,  P. Mickey WILLIAMS ,  William I. WOOD ,  Daniel G. YANSURA ,  James PAN

IPC: G01N33/574

CPC classification number: C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.