公开(公告)号：US20240376223A1

公开(公告)日：2024-11-14

申请号：US18785404

申请日：2024-07-26

Applicant: Genentech, Inc.

Inventor： Yu-Waye Chu ,  Iraj Hosseini ,  Saroja Ramanujan ,  Kapil Gadkar ,  Chi-Chung Li

IPC: C07K16/28 ,  A61K31/573 ,  A61K39/00 ,  A61K39/395

Abstract: The invention provides methods of dosing for the treatment of cancers, such as B cell proliferative disorders, with anti-cluster of differentiation 20 (CD20)/anti-cluster of differentiation 3 (CD3) bispecific antibodies.

公开(公告)号：US20230049152A1

公开(公告)日：2023-02-16

申请号：US17864074

申请日：2022-07-13

Applicant: GENENTECH, INC.

Inventor： Gautham Gampa ,  Iraj Hosseini ,  Mahrukh Huseni ,  James T. Koerber ,  Jian Mehr-Dean Payandeh ,  Sascha Rutz ,  Yonglian Sun ,  Cecilia P. C. Chiu ,  Teresita A. Delfino

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K45/06

Abstract: The present disclosure provides anti-CCR8 antibodies, and compositions and methods of their preparation and use.

公开(公告)号：US11542308B2

公开(公告)日：2023-01-03

申请号：US17664589

申请日：2022-05-23

Applicant: Genentech, Inc.

Inventor： Yichin Liu ,  Christine Carine Moussion ,  Travis William Bainbridge ,  Iraj Hosseini ,  Gregory Alan Lazar ,  Sivan Cohen ,  Christopher Charles Kemball ,  Jill M. Schartner

IPC: C07K14/475 ,  A61K38/18 ,  A61K31/713 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

Abstract: The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US20240331829A1

公开(公告)日：2024-10-03

申请号：US18626741

申请日：2024-04-04

Applicant: Genentech, Inc.

Inventor： Mohammad Jafarnejad ,  Louis Russell Joslyn ,  Iraj Hosseini ,  Saroja Ramanujan

IPC: G16H20/17 ,  G16B15/30

CPC classification number: G16H20/17 ,  G16B15/30

Abstract: The present disclosure relates generally to the field of immunology and oncology, and particularly to systems and methods for use in treating various disorders, such as those associated with cell signaling mediated by cytokines. Some embodiments of the disclosure provide quantitative system pharmacology (QSP) models developed to capture the complex interactions between drug pharmacokinetics and the differential expansion of multiple immune cell subsets across tissues and tumor.

公开(公告)号：US20230242659A1

公开(公告)日：2023-08-03

申请号：US18173417

申请日：2023-02-23

Applicant: Genentech, Inc.

Inventor： Yu-Waye Chu ,  Iraj Hosseini ,  Saroja Ramanujan ,  Kapil Gadkar ,  Chi-Chung Li

IPC: C07K16/28 ,  A61K39/395 ,  A61K31/573

CPC classification number: C07K16/2887 ,  C07K16/2809 ,  C07K16/2827 ,  A61K39/3955 ,  C07K16/2866 ,  A61K31/573 ,  C07K2317/41 ,  C07K2317/24 ,  A61K2039/545

Abstract: The invention provides methods of dosing for the treatment of cancers, such as B cell proliferative disorders, with anti-cluster of differentiation 20 (CD20)/anti-cluster of differentiation 3 (CD3) bispecific antibodies.

公开(公告)号：US12240910B2

公开(公告)日：2025-03-04

申请号：US17864074

申请日：2022-07-13

Applicant: GENENTECH, INC.

Inventor： Gautham Gampa ,  Iraj Hosseini ,  Mahrukh Huseni ,  James Thomas Koerber ,  Jian Mehr-Dean Payandeh ,  Sascha Rutz ,  Yonglian Sun ,  Cecilia P. C. Chiu ,  Teresita Arenzana Delfino

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: The present disclosure provides anti-CCR8 antibodies, and compositions and methods of their preparation and use.

公开(公告)号：US11466094B2

公开(公告)日：2022-10-11

申请号：US15813657

申请日：2017-11-15

Applicant: Genentech, Inc.

Inventor： Yu-Waye Chu ,  Iraj Hosseini ,  Saroja Ramanujan ,  Kapil Gadkar ,  Chi-Chung Li

IPC: A61K31/573 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00

Abstract: The invention provides methods of dosing for the treatment of cancers, such as B cell proliferative disorders, with anti-cluster of differentiation 20 (CD20)/anti-cluster of differentiation 3 (CD3) bispecific antibodies.