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公开(公告)号：US10894940B2
公开(公告)日：2021-01-19
申请号：US16218323
申请日：2018-12-12
Applicant: GENENTECH, INC.
Inventor： Dinesh Baskar , Jenny Hsiung , Woon-Lam Susan Leung , Inn H. Yuk
Abstract: An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.
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公开(公告)号：US11939559B2
公开(公告)日：2024-03-26
申请号：US17148190
申请日：2021-01-13
Applicant: Genentech, Inc.
Inventor： Dinesh Baskar , Jenny Hsiung , Woon-Lam Susan Leung , Inn H. Yuk
CPC classification number: C12M23/14 , C12M23/28 , C12M27/16 , C12M29/10 , C12M29/20 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/48 , C12N5/0018 , C12N2500/05
Abstract: An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.
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公开(公告)号：US10190084B2
公开(公告)日：2019-01-29
申请号：US14480366
申请日：2014-09-08
Applicant: Genentech, Inc.
Inventor： Dinesh Baskar , Jenny Hsiung , Woon-Lam Susan Leung , Inn H. Yuk
Abstract: An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.
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