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    Devices, methods, and systems for shrinking tissues
    4.
    发明授权
    Devices, methods, and systems for shrinking tissues 有权
    用于收缩组织的装置，方法和系统

    公开(公告)号：US06772013B1

    公开(公告)日：2004-08-03

    申请号：US09441109

    申请日：1999-11-16

    申请人： Frank Ingle ,  Garry Carter ,  Michael D. Laufer

    发明人： Frank Ingle ,  Garry Carter ,  Michael D. Laufer

    IPC分类号： A61F200

    CPC分类号： A61N1/403 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1482 ,  A61B18/1492 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00505 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00898 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61N1/06

    摘要： Devices, systems, and method for treating urinary incontinence generally relying on energy delivered to a patient's own pelvic support tissue to selectively contract or shrink at least a portion of that pelvic support tissue so as to reposition the bladder. The energy will preferably be applied to the endopelvic fascia and/or an arcus tendineus fascia pelvis. A variety of devices and methods are provided for applying gentle resistive heating of these and other tissues to cause them to contract without imposing significant injury on the surrounding tissue structures. By applying sufficient energy over a predetermined time, the tissue can be raised to a temperature which results in contraction without significant necrosis or other tissue damage. By selectively contracting the support tissues, the bladder neck, sphincter, and other components of the urinary tract responsible for the control of urinary flow can be reconfigured or supported in a manner which reduces urinary leakage.

    摘要翻译： 用于治疗尿失禁的装置，系统和方法通常依赖于递送至患者自己的骨盆支撑组织的能量来选择性地收缩或收缩该盆腔支撑组织的至少一部分，以便重新定位膀胱。 能量将优选地应用于内耳筋膜和/或腱骨筋膜骨盆。 提供了各种装置和方法来施加这些和其他组织的温和电阻加热，以使它们收缩而不对周围组织结构造成重大伤害。 通过在预定时间内施加足够的能量，组织可以升高到导致收缩而不显着坏死或其他组织损伤的温度。 通过选择性地收缩支撑组织，可以以减少尿液泄漏的方式重新配置或支撑膀胱颈，括约肌和负责控制尿流的尿道的其他成分。

    Noninvasive devices, methods and systems for shrinking of tissues
    7.
    发明申请
    Noninvasive devices, methods and systems for shrinking of tissues 审中-公开
    用于收缩组织的无创器件，方法和系统

    公开(公告)号：US20050288680A1

    公开(公告)日：2005-12-29

    申请号：US11215156

    申请日：2005-08-29

    申请人： Frank Ingle ,  Garry Carter ,  Robert Laird ,  John Claude ,  Paul Do ,  Brian Mosel

    发明人： Frank Ingle ,  Garry Carter ,  Robert Laird ,  John Claude ,  Paul Do ,  Brian Mosel

    IPC分类号： A61B18/12 ,  A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61B18/14 ,  A61N1/06 ,  A61N1/40 ,  A61B19/00

    CPC分类号： A61B18/1482 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/003 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00505 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00791 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N1/06 ,  A61N1/403 ,  A61N7/02

    摘要： The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy heats fascia and other collagenated support tissues, causing them to contract. The energy can be applied intermittently, often between a pair of large plate electrodes having cooled flat electrode surfaces, the electrodes optionally being supported by a clamp structure. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue, particularly where the electrode surfaces are cooled before, during, and after an intermittent-heating cycle. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia. Alternatively, chilled “liquid electrodes” may direct current through a selected portion of the bladder (or other body cavity) while also cooling the bladder wall, an insulating gas can prevent heating of an alternative bladder portion and the adjacent tissues, and/or ultrasound transducers direct energy through an intermediate tissue and into fascia with little or no injury to the intermediate tissue. Cooled electrodes may be used to chill an intermediate engaged tissue so as to cause the maximum temperature difference between the target tissue and the intermediate tissue prior to initiating RF heating. This allows the dimensions of tissue reaching the treatment temperature to be controlled and/or minimized, the dimensions of protected intermediate tissue to be maximized, and the like.

    摘要翻译： 本发明提供了用于收缩胶原组织的改进的装置，方法和系统，特别是通过将能量引导到患者自己的支撑组织以非侵入性方式治疗尿失禁。 这种能量加热筋膜和其他胶原支持组织，导致它们收缩。 间歇地施加能量，通常在具有冷却的平坦电极表面的一对大平板电极之间，电极可选地由夹持结构支撑。 这种冷却的平板电极能够将电能引导通过中间组织并进入筋膜，同时冷却的电极表面防止对中间组织的损伤，特别是在电极表面在间歇加热循环之前，期间和之后冷却。 理想地，平板电极包括包括分立电极表面段的电极阵列，使得可以改变电流通量以选择性地靶向仪表板。 或者，冷却的“液体电极”可以引导电流通过膀胱（或其他体腔）的选定部分，同时还冷却膀胱壁，绝缘气体可以防止替代膀胱部分和相邻组织和/或超声波的加热 换能器将能量通过中间组织直接导入筋膜，对中间组织几乎没有或没有损伤。 冷却的电极可用于冷却中间接合组织，以便在开始RF加热之前引起目标组织和中间组织之间的最大温差。 这允许控制和/或最小化达到治疗温度的组织的尺寸，被保护的中间组织的尺寸被最大化等等。

    Apparatus and methods for uniformly distributing coolant within a cryo-ablation device
    9.
    发明授权
    Apparatus and methods for uniformly distributing coolant within a cryo-ablation device 有权
    在冷冻消融装置内均匀分配冷却剂的装置和方法

    公开(公告)号：US08469919B2

    公开(公告)日：2013-06-25

    申请号：US12388399

    申请日：2009-02-18

    申请人： Frank Ingle ,  Raphael Hon

    发明人： Frank Ingle ,  Raphael Hon

    IPC分类号： A61B18/18

    CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： Apparatus and methods for uniformly distributing coolant within a cryo-ablation device. A nozzle apparatus includes a tubular member having a plurality of angled apertures that induce swirling of coolant streams dispersed through the angled apertures. Coolant swirling round the tubular member and along an inner surface of an inflatable balloon element inflates the balloon element and cryogenically ablate tissue. The swirling action achieved using angled apertures uniformly distributes coolant along the inner surface of the balloon such that the temperatures along an inner surface of the balloon element and ablation of tissue adjacent to the balloon element are substantially uniform.

    摘要翻译： 在冷冻消融装置内均匀分配冷却剂的装置和方法。 喷嘴装置包括管状构件，其具有多个成角度的孔，其引导分散通过倾斜孔的冷却剂流的旋转。 冷却液在管状构件周围旋转并且沿着可充气球囊元件的内表面膨胀，从而使球囊元件膨胀并且低温地烧蚀组织。 使用角度孔使得的旋转动作沿着球囊的内表面均匀地分布冷却剂，使得沿着球囊元件的内表面的温度和与球囊元件相邻的组织的消融基本上是均匀的。

    CARDIAC FUNCTION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION
    10.
    发明申请
    CARDIAC FUNCTION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION 有权
    心脏功能监测器使用信号指示铅运动

    公开(公告)号：US20110319778A1

    公开(公告)日：2011-12-29

    申请号：US13168531

    申请日：2011-06-24

    申请人： Robert J. Sweeney ,  Allan C. Shuros ,  Krzysztof Z. Siejko ,  David C. Olson ,  Frank Ingle

    发明人： Robert J. Sweeney ,  Allan C. Shuros ,  Krzysztof Z. Siejko ,  David C. Olson ,  Frank Ingle

    IPC分类号： A61B5/0245 ,  A61N1/365

    CPC分类号： A61N1/36514 ,  A61B5/02133 ,  A61B5/026 ,  A61N1/08 ,  A61N1/36142 ,  A61N1/36578

    摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.

    摘要翻译： 描述使用指示引导运动的信息来监测心脏功能的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并且被配置为获得指示可植入引线的移动的信息， 一个心脏的动作。 该系统可以包括被配置为获得指示心脏电活动的信息的感测电路。 该系统可以包括配置成构造代表心脏收缩的模板的处理器电路，其中可以使用指示可植入导线的运动的信息来构建模板，至少部分地由于心脏的运动 并且使用指示在收缩期间感测到的心脏电活动的信息。