摘要:
The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as through the introduction of genetic elements using viruses, the methods of the present invention reduce the risk of activating oncogenes in the iPS cells. The methods of the invention generate iPS cells that can be free of genetic modifications and thus have greater potential for use as therapeutic agents than those generated by existing methods.
摘要:
The present invention provides a security document and method of production thereof. The security document (10) comprises: a polymer substrate (12) having first (14) and second (22) surfaces; a security feature (16) formed in a region of at least one of said first and second surfaces of said polymer substrate; an opacifying layer (18, 24) formed on at least a portion of at least one of said first and second surfaces of said polymer substrate; a printed design formed on at least a portion of said opacifying layer; and wherein said security feature is formed at least prior to said printed design being formed.
摘要:
A tissue-separating catheter assembly comprises a rotatable shaft, having a distal shaft portion, and a tissue separator device extending along the shaft. The tissue separator device has a distal separator part at the distal shaft portion movable between a retracted state, towards the distal shaft portion, and an outwardly extending, operational state, away from the distal shaft portion. A localization device is movable to a radially expanded state. An expandable tubular element is movable so that its outer end is generally axially aligned with the localization device so to capture a separated tissue section therebetween to aid removal of the separated tissue section from the patient.
摘要:
There is described a method of tracking an article (30) and protecting it against tampering and counterfeiting, the method comprising the steps of providing an article; providing a film (1c) for wrapping or labelling the article; marking the film with a code (5c); defining an area of interest (35) on the article or the film; wrapping or labelling the article with the film so that the code at least partially overlays the area of interest to define a tracking zone in the region of the at least partial overlay; imaging the tracking zone of the wrapped or labelled article; and storing the imaged date for identifying the article. There is also described, use of a frequency-tripled neodymium-doped yttrium aluminium garnet (nd:YAG) laser in marking a code (5c) on a film (1c), the code comprising an at least partly random pattern of perforations (21, 23, 25).
摘要:
A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at amino acid position 329, or at two or all of amino acid positions 329, 331 and 322 of the human IgG Fc region. Such variants display altered effector function. For example, C1q binding and/or complement dependent cytotoxicity (CDC) activity may be reduced or abolished in the variant polypeptide. The application also describes an immune complex and an assay for determining binding of an analyte, such as an Fc region-containing polypeptide, to a receptor.
摘要:
The present invention provides a security document and method of production thereof. The security document (10) comprises: a polymer substrate (12) having first (14) and second (22) surfaces; a security feature (16) formed in a region of at least one of said first and second surfaces of said polymer substrate; an opacifying layer (18, 24) formed on at least a portion of at least one of said first and second surfaces of said polymer substrate; a printed design formed on at least a portion of said opacifying layer; and wherein said security feature is formed at least prior to said printed design being formed.
摘要:
The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as through the introduction of genetic elements using viruses, the methods of the present invention reduce the risk of activating oncogenes in the iPS cells. The methods of the invention generate iPS cells that can be free of genetic modifications and thus have greater potential for use as therapeutic agents than those generated by existing methods.
摘要:
A method of and apparatus for assembling an aircraft wheel or brake (10) component on an axle (26) of an undercarriage in which a holder (12) is provided for the component along with a lifting device (28). The lifting device is used to lift the holder with the component therein to a position where the component is substantially in axial alignment with the axle. Once in that position, assembly of the component on the axle can take place by moving the component axially on to the axle. The holder can then be lowered away from the assembled component.
摘要:
A tissue separator assembly has an elongate tubular member and a tissue separator device located at a distal end of the elongate tubular member. An elongate coupler extends through the lumen of the elongate tubular member and has a distal coupler end. A tissue localization assembly has an elongate member and a localization device located at the distal end of the elongate member. The localization device may be movable from a first, radially-contracted state to a second, radially-expandable state. The distal coupler end of the elongate coupler and the proximal end of the elongate tubular member of the localization assembly are joinable to one another to permit docking of the tissue localization assembly to the tissue separator assembly. Methods of use of this device are also described.
摘要:
The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy heats fascia and other collagenated support tissues, causing them to contract. The energy can be applied intermittently, often between a pair of large plate electrodes having cooled flat electrode surfaces, the electrodes optionally being supported by a clamp structure. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue, particularly where the electrode surfaces are cooled before, during, and after an intermittent-heating cycle. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia. Alternatively, chilled “liquid electrodes” may direct current through a selected portion of the bladder (or other body cavity) while also cooling the bladder wall, an insulating gas can prevent heating of an alternative bladder portion and the adjacent tissues, and/or ultrasound transducers direct energy through an intermediate tissue and into fascia with little or no injury to the intermediate tissue. Cooled electrodes may be used to chill an intermediate engaged tissue so as to cause the maximum temperature difference between the target tissue and the intermediate tissue prior to initiating RF heating. This allows the dimensions of tissue reaching the treatment temperature to be controlled and/or minimized, the dimensions of protected intermediate tissue to be maximized, and the like.