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1.发明申请Distributed System Providing Dynamic Indexing And Visualization Of Genomic Data 审中-公开分布式系统提供基因组数据的动态索引和可视化公开(公告)号：US20140368550A1
公开(公告)日：2014-12-18
申请号：US14363788
申请日：2012-12-07
申请人： Five3 Genomics, LLC
CPC分类号： G06T3/40 , G06F19/22 , G06F19/26 , G06F19/28 , G06T2200/24 , G09G5/373 , G09G2340/045 , G09G2354/00
摘要： Systems and methods for dynamic visualization of genomic data are provided in which a genomic visualization system adapts presentation of information content according to scale-relevant annotations within a sequence object.
摘要翻译： 提供了用于基因组数据的动态可视化的系统和方法，其中基因组可视化系统根据序列对象内的比例相关注释来适应信息内容的呈现。
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2.发明申请公开(公告)号：US20200185053A1
公开(公告)日：2020-06-11
申请号：US16733013
申请日：2020-01-02
发明人： Shahrooz Rabizadeh , John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Patrick Soon-Shiong
摘要： Omics patient data are analyzed using sequences or diff objects of tumor and matched normal tissue to identify patient and disease specific mutations, using transcriptomic data to identify expression levels of the mutated genes, and pathway analysis based on the so obtained omic data to identify specific pathway characteristics for the diseased tissue. Most notably, many different tumors have shared pathway characteristics, and identification of a pathway characteristic of a tumor may thus indicate effective treatment options ordinarily not considered when tumor analysis is based on anatomical tumor type only.
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公开(公告)号：US20190066262A1
公开(公告)日：2019-02-28
申请号：US16169946
申请日：2018-10-24
申请人： Five3 Genomics, LLC
摘要： Systems and methods for dynamic visualization of genomic data are provided in which a genomic visualization system adapts presentation of information content according to scale-relevant annotations within a sequence object.
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公开(公告)号：US10176295B2
公开(公告)日：2019-01-08
申请号：US14499023
申请日：2014-09-26
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
IPC分类号： G06F19/22
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US11361844B2
公开(公告)日：2022-06-14
申请号：US16032421
申请日：2018-07-11
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US10961586B2
公开(公告)日：2021-03-30
申请号：US15439717
申请日：2017-02-22
申请人： Five3 Genomics, LLC
IPC分类号： C12Q1/68 , C12Q1/6886 , G16B20/00 , G16B30/00 , G16B40/00 , G16H50/20 , C12Q1/6869
摘要： Contemplated systems and methods allow for computational genomic analysis using paired-end sequence analysis and split read refinement to thereby identify high-confidence breakpoints associated with high copy numbers and orientation of rearrangements, which is then the basis for full reconstruction of double minutes (DM). In especially preferred aspects, the DM will also include an oncogene or tumor suppressor gene, and/or may be found in blood or blood derived fluids.
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公开(公告)号：US10733701B2
公开(公告)日：2020-08-04
申请号：US16169946
申请日：2018-10-24
申请人： Five3 Genomics, LLC
摘要： Systems and methods for dynamic visualization of genomic data are provided in which a genomic visualization system adapts presentation of information content according to scale-relevant annotations within a sequence object.
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公开(公告)号：US10140683B2
公开(公告)日：2018-11-27
申请号：US14363788
申请日：2012-12-07
申请人： Five3 Genomics, LLC
摘要： Systems and methods for dynamic visualization of genomic data are provided in which a genomic visualization system adapts presentation of information content according to scale-relevant annotations within a sequence object.
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公开(公告)号：US20160103949A1
公开(公告)日：2016-04-14
申请号：US14893403
申请日：2014-05-28
申请人： FIVE3 GENOMICS, LLC
摘要： Systems and methods are presented in which omics data from multiple cell or tissue samples are used to identify pathway elements that are associated with a treatment parameter of the cell or tissue (e.g., resistance towards a specific drug). So identified pathway elements are then modulated in silico in a statistical factor graph model to provide a modified data set that is re-evaluated with respect to the treatment parameter. Such systems and models are particularly useful for recommendation of multi-drug treatments for treatment-nave patients.
摘要翻译： 提出了系统和方法，其中来自多个细胞或组织样品的氨基酸数据用于鉴定与细胞或组织的治疗参数相关的途径元件（例如对特定药物的抵抗力）。 然后，在统计因子图模型中，以计算机调制所识别的通路元件，以提供相对于治疗参数重新评估的修改数据集。 这样的系统和模型对于治疗患者的多药物治疗的推荐特别有用。
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10.发明申请公开(公告)号：US20150134662A1
公开(公告)日：2015-05-14
申请号：US14541068
申请日：2014-11-13
申请人： Five3 Genomics, LLC
CPC分类号： H04L67/06 , G06F17/30076 , G06F19/22 , G06F19/28
摘要： “Omic” digital data transport systems and methods are disclosed. The disclosed systems and methods employ a transport server that assembles a transport group larger numbers of omic output files on the basis of machine specific annotation from one or more sequencing devices and user input related to one or more attributes for the omic output files.
摘要翻译： 公开了“Omic”数字数据传输系统和方法。 所公开的系统和方法使用传输服务器，其基于来自一个或多个排序设备的机器特定注释和与omic输出文件的一个或多个属性相关的用户输入来组装传输组较大数量的Omic输出文件。
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