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1.发明申请Distributed System Providing Dynamic Indexing And Visualization Of Genomic Data 审中-公开分布式系统提供基因组数据的动态索引和可视化公开(公告)号：US20140368550A1
公开(公告)日：2014-12-18
申请号：US14363788
申请日：2012-12-07
申请人： Five3 Genomics, LLC
CPC分类号： G06T3/40 , G06F19/22 , G06F19/26 , G06F19/28 , G06T2200/24 , G09G5/373 , G09G2340/045 , G09G2354/00
摘要： Systems and methods for dynamic visualization of genomic data are provided in which a genomic visualization system adapts presentation of information content according to scale-relevant annotations within a sequence object.
摘要翻译： 提供了用于基因组数据的动态可视化的系统和方法，其中基因组可视化系统根据序列对象内的比例相关注释来适应信息内容的呈现。
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2.发明申请公开(公告)号：US20200185053A1
公开(公告)日：2020-06-11
申请号：US16733013
申请日：2020-01-02
发明人： Shahrooz Rabizadeh , John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Patrick Soon-Shiong
摘要： Omics patient data are analyzed using sequences or diff objects of tumor and matched normal tissue to identify patient and disease specific mutations, using transcriptomic data to identify expression levels of the mutated genes, and pathway analysis based on the so obtained omic data to identify specific pathway characteristics for the diseased tissue. Most notably, many different tumors have shared pathway characteristics, and identification of a pathway characteristic of a tumor may thus indicate effective treatment options ordinarily not considered when tumor analysis is based on anatomical tumor type only.
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公开(公告)号：US20190066262A1
公开(公告)日：2019-02-28
申请号：US16169946
申请日：2018-10-24
申请人： Five3 Genomics, LLC
摘要： Systems and methods for dynamic visualization of genomic data are provided in which a genomic visualization system adapts presentation of information content according to scale-relevant annotations within a sequence object.
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公开(公告)号：US10176295B2
公开(公告)日：2019-01-08
申请号：US14499023
申请日：2014-09-26
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
IPC分类号： G06F19/22
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US20220277809A1
公开(公告)日：2022-09-01
申请号：US17739792
申请日：2022-05-09
申请人： Five3 Genomics, LLC
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US20190392921A1
公开(公告)日：2019-12-26
申请号：US16562186
申请日：2019-09-05
申请人： Five3 Genomics, LLC
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
IPC分类号： G16B30/00
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US10193956B2
公开(公告)日：2019-01-29
申请号：US14541068
申请日：2014-11-13
申请人： Five3 Genomics, LLC
摘要： “Omic” digital data transport systems and methods are disclosed. The disclosed systems and methods employ a transport server that assembles a transport group larger numbers of omic output files on the basis of machine specific annotation from one or more sequencing devices and user input related to one or more attributes for the omic output files.
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公开(公告)号：US20180322245A1
公开(公告)日：2018-11-08
申请号：US16032421
申请日：2018-07-11
发明人： John Zachary Sanborn , Charles Joseph Vaske , Stephen Charles Benz , Shahrooz Rabizadeh , Nicole Hensley , Patrick Soon-Shiong
IPC分类号： G06F19/22
CPC分类号： G06F19/22
摘要： Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format.
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公开(公告)号：US20170159133A1
公开(公告)日：2017-06-08
申请号：US15439717
申请日：2017-02-22
申请人： Five3 Genomics, LLC
CPC分类号： C12Q1/6886 , C12Q1/6869 , C12Q2600/106 , C12Q2600/172 , G16B20/00 , G16B30/00 , G16B40/00 , G16H50/20
摘要： Contemplated systems and methods allow for computational genomic analysis using paired-end sequence analysis and split read refinement to thereby identify high-confidence breakpoints associated with high copy numbers and orientation of rearrangements, which is then the basis for full reconstruction of double minutes (DM). In especially preferred aspects, the DM will also include an oncogene or tumor suppressor gene, and/or may be found in blood or blood derived fluids.
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10.发明申请Systems And Methods For Learning And Identification Of Regulatory Interactions In Biological Pathways 审中-公开用于学习和识别生物学途径中的调节相互作用的系统和方法公开(公告)号：US20150262082A1
公开(公告)日：2015-09-17
申请号：US14434745
申请日：2013-10-09
申请人： FIVE3 GENOMICS, LLC
摘要： Contemplated systems and methods provide for machine learning and identification of regulatory interactions in biological pathways using a probabilistic graphical model, and especially for identification of interaction correlations among the regulatory parameters.
摘要翻译： 考虑的系统和方法提供机器学习和使用概率图形模型识别生物学途径中的调节相互作用，特别是用于识别调节参数之间的相互作用相关性。
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