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    Kit and method for measuring measurement target substance in biological sample
    1.
    发明授权
    Kit and method for measuring measurement target substance in biological sample 有权

    公开(公告)号：US11674966B2

    公开(公告)日：2023-06-13

    申请号：US16584079

    申请日：2019-09-26

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki Chiku ,  Tomoaki Yoshioka ,  Kousuke Watanabe ,  Kazuhiro Hamada ,  Kouitsu Sasaki

    IPC: G01N33/58 ,  C07F5/02 ,  C09K11/06

    CPC classification number: G01N33/582 ,  C07F5/022 ,  C09K11/06 ,  G01N33/585 ,  C09K2211/1022

    Abstract: An object of the present invention is to provide a kit and a method which are capable of measuring a measurement target substance in a biological sample with high precision in a measurement range from a low concentration range to a high concentration range. According to the present invention, there is provided a kit for measuring a measurement target substance in a biological sample, including a labeled particle having a first binding substance capable of binding to a measurement target substance in a biological sample, and a substrate having a second binding substance capable of binding to any one of the measurement target substance or the first binding substance, in which the labeled particle is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle.




    Each symbol in Formula (1) has the meaning described in the present specification.

    Kit for quantitatively determining substance to be measured in biological sample
    2.
    发明授权
    Kit for quantitatively determining substance to be measured in biological sample 有权

    公开(公告)号：US11255849B2

    公开(公告)日：2022-02-22

    申请号：US16115595

    申请日：2018-08-29

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki Chiku ,  Noriyuki Kasagi

    IPC: G01N33/543 ,  G01N33/53 ,  G01N21/64 ,  G01N21/78

    Abstract: An object of the present invention is to provide a kit in which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy, even in a case where the substance to be measured includes a plurality of substances having different structures. According to the present invention, a kit for quantitatively determining a substance to be measured in a biological sample, the kit including fluorescent particles that have a first binding substance capable of binding to the substance to be measured; and a substrate that has a detection region having a second binding substance capable of binding to any one of the substance to be measured and the first binding substance, in which the substance to be measured includes at least three types of substances having different structures, and the first binding substance includes at least three types of binding substances which are capable of binding to the at least three types of substances having different structures, respectively, is provided.

    Progesterone measuring kit, progesterone measuring method, and progesterone measuring reagent
    3.
    发明授权
    Progesterone measuring kit, progesterone measuring method, and progesterone measuring reagent 有权

    公开(公告)号：US12235263B2

    公开(公告)日：2025-02-25

    申请号：US16999138

    申请日：2020-08-21

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki Chiku ,  Takeru Shigemura ,  Kousuke Watanabe ,  Yoshinori Kanazawa ,  Kouitsu Sasaki ,  Kazuhei Kaneko

    IPC: G01N33/543 ,  G01N21/64 ,  G01N33/547

    Abstract: An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of progesterone in a wide concentration range from a low concentration to a high concentration, in the measurement of progesterone in a biological sample. The present invention provides a progesterone measuring kit including a first particle having a label and modified with a first binding substance, a second particle having no label and modified with a second binding substance, a flow channel, and a substrate, in which the first particle contains a compound represented by Formula (1) and a particle, and an average particle diameter of the first particles is 50 to 250 nm, an average particle diameter of the second particles is 70 to 500 nm, and the average particle diameter of the second particles is larger than the average particle diameter of the first particles. Each symbol in the formula has the meaning described in the present specification.

    KIT AND METHOD FOR MEASURING MEASUREMENT TARGET SUBSTANCE IN BIOLOGICAL SAMPLE
    4.
    发明申请
    KIT AND METHOD FOR MEASURING MEASUREMENT TARGET SUBSTANCE IN BIOLOGICAL SAMPLE 审中-公开

    公开(公告)号：US20200025748A1

    公开(公告)日：2020-01-23

    申请号：US16585306

    申请日：2019-09-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki Chiku ,  Kousuke Watanabe ,  Kazuhei Kaneko ,  Kazuhiro Hamada ,  Kouitsu Sasaki ,  Tomoaki Yoshioka ,  Naoyuki Hanaki

    IPC: G01N33/533 ,  C07D209/90 ,  G01N21/64

    Abstract: An object of the present invention is to provide a kit and a method which are capable of measuring a measurement target substance in a biological sample with high precision in a measurement range from a low concentration range to a high concentration range. According to the present invention, there is provided a kit for measuring a measurement target substance in a biological sample, including a labeled particle having a first binding substance capable of binding to a measurement target substance in a biological sample, and a substrate having a second binding substance capable of binding to any one of the measurement target substance or the first binding substance, in which the labeled particle is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.

    Kit, method, and reagent for measuring measurement target substance
    5.
    发明授权
    Kit, method, and reagent for measuring measurement target substance 有权

    公开(公告)号：US11733244B2

    公开(公告)日：2023-08-22

    申请号：US16585758

    申请日：2019-09-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki Chiku ,  Kousuke Watanabe ,  Kazuhei Kaneko ,  Kazuhiro Hamada ,  Kouitsu Sasaki ,  Tomoaki Yoshioka ,  Naoyuki Hanaki

    IPC: G01N33/58 ,  C07D209/56

    CPC classification number: G01N33/582 ,  C07D209/56 ,  G01N33/585

    Abstract: An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of a measurement target substance in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance, the kit including: a first particle having a label and modified with a first binding substance capable of specifically binding to a measurement target substance; a second particle having no label and modified with a second binding substance incapable of specifically binding to the measurement target substance; a flow channel for flowing the first particle and the second particle; and a substrate having a third binding substance capable of specifically binding to the measurement target substance or a substance capable of binding to the first binding substance, in which the first particle having a label is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle.




    Each symbol in Formula (1) has the meaning described in the present specification.

    Kit for quantitatively determining bile acid in biological sample, and method for quantitatively determining bile acid in biological sample
    6.
    发明授权
    Kit for quantitatively determining bile acid in biological sample, and method for quantitatively determining bile acid in biological sample 有权

    公开(公告)号：US10883986B2

    公开(公告)日：2021-01-05

    申请号：US16115594

    申请日：2018-08-29

    Applicant: FUJIFILM Corporation

    Inventor： Noriyuki Kasagi ,  Hiroyuki Chiku ,  Ayumi Era

    IPC: G01N33/543 ,  G01N33/48 ,  G01N33/53

    Abstract: An object of the present invention is to provide a kit for quantitatively determining a bile acid, in which it is possible to improve measurement accuracy by sufficiently dissociating the bile acid from a polymer component, and to rapidly carry out the quantitative determination of the bile acid with high accuracy under various environments, and a method for quantitatively determining the bile acid.
    According to the present invention, a kit for quantitatively determining a bile acid in a biological sample, including a compound represented by General Formula (I) defined in the present specification in a dry state; a fluorescent particle that has a first binding substance capable of binding to the bile acid; and a substrate that has a detection region having a second binding substance capable of binding to any one of the bile acid and the first binding substance, is provided.

    KIT AND METHOD FOR MEASURING MEASUREMENT TARGET SUBSTANCE IN BIOLOGICAL SAMPLE
    7.
    发明申请
    KIT AND METHOD FOR MEASURING MEASUREMENT TARGET SUBSTANCE IN BIOLOGICAL SAMPLE 审中-公开

    公开(公告)号：US20200018765A1

    公开(公告)日：2020-01-16

    申请号：US16584079

    申请日：2019-09-26

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki Chiku ,  Tomoaki Yoshioka ,  Kousuke Watanabe ,  Kazuhiro Hamada ,  Kouitsu Sasaki

    IPC: G01N33/58 ,  C07F5/02 ,  C09K11/06

    Abstract: An object of the present invention is to provide a kit and a method which are capable of measuring a measurement target substance in a biological sample with high precision in a measurement range from a low concentration range to a high concentration range. According to the present invention, there is provided a kit for measuring a measurement target substance in a biological sample, including a labeled particle having a first binding substance capable of binding to a measurement target substance in a biological sample, and a substrate having a second binding substance capable of binding to any one of the measurement target substance or the first binding substance, in which the labeled particle is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.

    Kit, method and reagent for measuring measurement target substance
    10.
    发明授权
    Kit, method and reagent for measuring measurement target substance 有权

    公开(公告)号：US11519860B2

    公开(公告)日：2022-12-06

    申请号：US16585406

    申请日：2019-09-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki Chiku ,  Tomoaki Yoshioka ,  Kousuke Watanabe ,  Kazuhiro Hamada ,  Kouitsu Sasaki

    IPC: G01N21/64 ,  G01N33/543 ,  C07F5/02

    Abstract: An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of a measurement target substance in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance, the kit including: a first particle having a label and modified with a first binding substance; a second particle having no label and modified with a second binding substance; a flow channel for flowing the first particle and the second particle; and a substrate having a third binding substance capable of specifically binding to the measurement target substance or a substance capable of binding to the first binding substance, in which the first particle having a label is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.

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