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公开(公告)号：US20230148412A1
公开(公告)日：2023-05-11
申请号：US17812415
申请日：2022-07-13
发明人： Doron LIPSON , Geoffrey Alan OTTO , Alexander Nevin PARKER , Philip James STEPHENS , Sean R. DOWNING , Mirna JAROSZ , Mikhail G. SHAPIRO , Roman YELENSKY
IPC分类号： C12Q1/6827 , C12Q1/6874 , G16B20/10 , G16B30/10 , G16B20/20 , G16B20/00 , G16B30/00
CPC分类号： C12Q1/6827 , C12Q1/6874 , G16B20/10 , G16B30/10 , G16B20/20 , G16B20/00 , G16B30/00 , C12Q1/6886
摘要： A method of analyzing a tumor sample comprising:
(a) acquiring a library comprising a plurality of tumor members from a tumor sample;
(b) contacting the library with a bait set to provide selected members;
(c) acquiring a read for a subgenomic interval from a tumor member from said library;
(d) aligning said read; and
(e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.-
公开(公告)号：US20230372338A1
公开(公告)日：2023-11-23
申请号：US18346029
申请日：2023-06-30
发明人： Siraj Mahamed ALI , Matthew J. HAWRYLUK , Jie HE , Doron LIPSON , Vincent A. MILLER , Jeffrey S. ROSS , Philip James STEPHENS
IPC分类号： A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/498 , A61K31/496 , A61K31/517 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
CPC分类号： A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/498 , A61K31/496 , A61K31/517 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C12Y207/10001 , C07K16/40 , C12N15/1137 , C12Q1/6883 , G01N33/573 , C12Q2600/156 , C07K2319/00 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Q2600/158 , G01N2333/912 , G01N2500/04
摘要： Methods and compositions for treating cholangiocarcinoma.
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公开(公告)号：US20220251667A1
公开(公告)日：2022-08-11
申请号：US17673718
申请日：2022-02-16
发明人： Maureen T. CRONIN , Garrett Michael FRAMPTON , Doron LIPSON , Vincent A. MILLER , Gary PALMER , Jeffrey S. ROSS , Philip James STEPHENS , Roman YELENSKY
IPC分类号： C12Q1/6886 , A61K31/565 , A61K31/4196 , A61K31/675 , A61K31/439 , A61K31/567 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/472 , A61K31/536 , A61K31/5415 , A61K45/06 , C07K14/72 , C07K16/28 , A61K31/436
摘要： Novel mutant ESR1 molecules and uses are disclosed.
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公开(公告)号：US20230241065A1
公开(公告)日：2023-08-03
申请号：US17817619
申请日：2022-08-04
发明人： Sean R. DOWNING , Matthew J. HAWRYLUK , Doron LIPSON , Alexander N. PARKER , Philip James STEPHENS
IPC分类号： A61K31/517 , C07K14/82 , C12N9/14 , C12Q1/6886 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C12N15/113
CPC分类号： A61K31/517 , A61K31/47 , A61K31/404 , A61K31/444 , A61K31/513 , A61K31/4412 , C07K14/82 , C12N9/14 , C12N15/1135 , C12Q1/6886 , C07K2319/00 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： Novel RET fusion molecules and uses are disclosed.
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公开(公告)号：US20220145402A1
公开(公告)日：2022-05-12
申请号：US17535492
申请日：2021-11-24
IPC分类号： C12Q1/6886 , A61K45/06
摘要： Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
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公开(公告)号：US20210283134A1
公开(公告)日：2021-09-16
申请号：US17204830
申请日：2021-03-17
发明人： Siraj Mahamed ALI , Matthew J. HAWRYLUK , Jie HE , Doron LIPSON , Vincent A. MILLER , Jeffrey S. ROSS , Philip James STEPHENS
IPC分类号： A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/498 , A61K31/496 , A61K31/517 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
摘要： Methods and compositions for treating cholangiocarcinoma.
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