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公开(公告)号：US10072017B2
公开(公告)日：2018-09-11
申请号：US15392727
申请日：2016-12-28
IPC分类号： C07D487/22 , C07D491/22 , C07D487/20 , C07D487/14
CPC分类号： C07D487/22 , C07D487/14 , C07D487/20 , C07D491/22
摘要： The invention relates to a compound of Formula I or IA compositions comprising compounds of Formula I or IA, and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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公开(公告)号：US20170204110A1
公开(公告)日：2017-07-20
申请号：US15392727
申请日：2016-12-28
IPC分类号： C07D487/22 , C07D491/22 , C07D487/20 , C07D487/14
CPC分类号： C07D487/22 , C07D487/14 , C07D487/20 , C07D491/22
摘要： The invention relates to a compound of Formula I or IA compositions comprising compounds of Formula I or IA, and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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公开(公告)号：US20170313659A1
公开(公告)日：2017-11-02
申请号：US15483413
申请日：2017-04-10
IPC分类号： C07D211/96 , A61K31/4245 , C07D413/12 , C07D405/14 , C07D401/14 , C07D401/12 , A61K45/06 , A61K31/7036 , A61K31/506 , A61K31/497 , A61K31/4725 , A61K31/4545 , A61K31/454 , A61K31/4525 , A61K31/4468 , A61K31/443 , A61K31/437 , C07D417/12 , C07D471/04
CPC分类号： C07D211/96 , A61K31/4245 , A61K31/437 , A61K31/443 , A61K31/4468 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/7036 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K2300/00
摘要： The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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公开(公告)号：US20230055237A1
公开(公告)日：2023-02-23
申请号：US17383797
申请日：2021-07-23
发明人： Michael P. Zawistoski , Christopher Oalmann , Feng Li , Andrew Kolodziej , Marshall Morningstar
IPC分类号： C07D498/20 , C07D487/20 , C07D487/10 , C07D519/00 , A61K45/06
摘要： The invention relates to a compound of Formula I, pharmaceutical compositions comprising a compound of Formula I, and pharmaceutically acceptable slats thereof, pharmaceutical compositions comprising such compounds and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula Ito a subject in need thereof.
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公开(公告)号：US09944603B2
公开(公告)日：2018-04-17
申请号：US15483413
申请日：2017-04-10
IPC分类号： C07D401/14 , A61K31/437 , C07D211/96 , C07D401/12 , A61K31/4525 , A61K31/4725 , A61K31/7036 , A61K45/06 , A61K31/506 , C07D417/12 , A61K31/454 , C07D413/12 , C07D405/14 , A61K31/4545 , C07D471/04 , A61K31/4245 , A61K31/443 , A61K31/497 , A61K31/4468
CPC分类号： C07D211/96 , A61K31/4245 , A61K31/437 , A61K31/443 , A61K31/4468 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/7036 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K2300/00
摘要： The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof.
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公开(公告)号：US09771327B2
公开(公告)日：2017-09-26
申请号：US14210232
申请日：2014-03-13
IPC分类号： C07D405/14 , A61K31/4468 , C07D211/96 , A61K31/437 , C07D471/04 , C07D401/12 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/14 , C07D413/12 , C07D417/12 , A61K31/4245 , A61K31/443 , A61K31/4525 , A61K31/4725 , A61K31/7036
CPC分类号： C07D211/96 , A61K31/4245 , A61K31/437 , A61K31/443 , A61K31/4468 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/7036 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K2300/00
摘要： The invention relates to a compound of Formula I and methods of treating CFTR (cystic fibrosis transmembrane conductance regulator) mediated diseases, in particular cystic fibrosis, comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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