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公开(公告)号：US09790215B2
公开(公告)日：2017-10-17
申请号：US14210273
申请日：2014-03-13
IPC分类号： A61K31/502 , C07D487/00 , C07D413/12 , A61K45/06 , C07D413/14 , C07D498/04 , A61K31/38 , A61K31/4245 , A61K31/443 , A61K31/47 , A61K31/5025 , A61K31/506 , A61K31/519 , C07D237/32 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D487/04 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/14 , C07D495/14 , C07D519/00
CPC分类号： C07D413/12 , A61K31/38 , A61K31/4245 , A61K31/443 , A61K31/47 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D237/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/14 , C07D498/04 , C07D519/00 , A61K2300/00
摘要： The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I to a patient in need thereof:
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公开(公告)号：US09783529B2
公开(公告)日：2017-10-10
申请号：US14210277
申请日：2014-03-13
IPC分类号： A61K31/502 , C07D237/26 , C07D413/12 , A61K45/06 , C07D413/14 , C07D498/04 , A61K31/38 , A61K31/4245 , A61K31/443 , A61K31/47 , A61K31/5025 , A61K31/506 , A61K31/519 , C07D237/32 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D487/04 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/14 , C07D495/14 , C07D519/00
CPC分类号： C07D413/12 , A61K31/38 , A61K31/4245 , A61K31/443 , A61K31/47 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D237/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/14 , C07D498/04 , C07D519/00 , A61K2300/00
摘要： The invention relates to a compound of having the following formulae and methods of treating cystic fibrosis:
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公开(公告)号：US10472357B2
公开(公告)日：2019-11-12
申请号：US15891846
申请日：2018-02-08
IPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K45/06 , A61K31/4196 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/519 , C07D487/04 , A61P11/00
摘要： The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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公开(公告)号：US20180230146A1
公开(公告)日：2018-08-16
申请号：US15891846
申请日：2018-02-08
IPC分类号： C07D471/04 , A61K31/444 , C07D487/04 , A61K31/4439 , A61P11/00 , A61K31/496 , A61K45/06 , A61K31/4196 , A61K31/4545 , A61K31/437 , A61K31/519
摘要： The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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公开(公告)号：US20170233388A1
公开(公告)日：2017-08-17
申请号：US15409991
申请日：2017-01-19
IPC分类号： C07D471/04 , A61K45/06 , A61K31/519 , A61K31/444 , A61K31/4545 , C07D487/04 , A61K31/437 , A61K31/496
CPC分类号： C07D471/04 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K45/06 , A61P11/00 , C07D487/04
摘要： The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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公开(公告)号：US10370366B2
公开(公告)日：2019-08-06
申请号：US15726813
申请日：2017-10-06
IPC分类号： C07D413/12 , A61K31/502 , A61K45/06 , C07D413/14 , C07D498/04 , A61K31/38 , A61K31/4245 , A61K31/443 , A61K31/47 , A61K31/5025 , A61K31/506 , A61K31/519 , C07D237/32 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D487/04 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/14 , C07D495/14 , C07D519/00
摘要： The invention relates to a compound of having the following formulae and methods of treating cystic fibrosis:
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公开(公告)号：US09926315B2
公开(公告)日：2018-03-27
申请号：US15409991
申请日：2017-01-19
IPC分类号： C07D471/02 , C07D471/04 , A61K31/437 , A61K31/496 , A61K45/06 , A61K31/4196 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/519 , C07D487/04
CPC分类号： C07D471/04 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K45/06 , A61P11/00 , C07D487/04
摘要： The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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公开(公告)号：US20170313659A1
公开(公告)日：2017-11-02
申请号：US15483413
申请日：2017-04-10
IPC分类号： C07D211/96 , A61K31/4245 , C07D413/12 , C07D405/14 , C07D401/14 , C07D401/12 , A61K45/06 , A61K31/7036 , A61K31/506 , A61K31/497 , A61K31/4725 , A61K31/4545 , A61K31/454 , A61K31/4525 , A61K31/4468 , A61K31/443 , A61K31/437 , C07D417/12 , C07D471/04
CPC分类号： C07D211/96 , A61K31/4245 , A61K31/437 , A61K31/443 , A61K31/4468 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/7036 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K2300/00
摘要： The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
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公开(公告)号：US20200017486A1
公开(公告)日：2020-01-16
申请号：US16511315
申请日：2019-07-15
IPC分类号： C07D413/12 , A61K31/502 , A61K45/06 , C07D413/14 , C07D498/04 , A61K31/38 , A61K31/4245 , A61K31/443 , A61K31/47 , A61K31/5025 , A61K31/506 , A61K31/519 , C07D237/32 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D487/04 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/14 , C07D495/14 , C07D519/00
摘要： The invention relates to a compound of having the following formulae and methods of treating cystic fibrosis:
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公开(公告)号：US09944603B2
公开(公告)日：2018-04-17
申请号：US15483413
申请日：2017-04-10
IPC分类号： C07D401/14 , A61K31/437 , C07D211/96 , C07D401/12 , A61K31/4525 , A61K31/4725 , A61K31/7036 , A61K45/06 , A61K31/506 , C07D417/12 , A61K31/454 , C07D413/12 , C07D405/14 , A61K31/4545 , C07D471/04 , A61K31/4245 , A61K31/443 , A61K31/497 , A61K31/4468
CPC分类号： C07D211/96 , A61K31/4245 , A61K31/437 , A61K31/443 , A61K31/4468 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/7036 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , A61K2300/00
摘要： The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof.
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