公开(公告)号：US11827720B2

公开(公告)日：2023-11-28

申请号：US15677667

申请日：2017-08-15

Applicant: F-star Therapeutics Limited

Inventor： Florian Ruker ,  Gottfried Himmler ,  Gordana Wozniak-Knopp

IPC: C07K16/00 ,  C07K16/46 ,  C07K16/28

CPC classification number: C07K16/468 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2887 ,  C07K2317/52

Abstract: The present invention provides a multivalent immunoglobulin or part thereof binding specifically to at least two cell surface molecules of a single cell with at least one modification in at least one structural loop region of the immunoglobulin determining binding to an epitope of the cell surface molecules wherein the unmodified immunoglobulin does not significantly bind to the epitope, its use and methods for producing it.

公开(公告)号：US20230340696A1

公开(公告)日：2023-10-26

申请号：US17963509

申请日：2022-10-11

Applicant: F-STAR THERAPEUTICS LIMITED

Inventor： Gottfried Himmler ,  Florian Ruker ,  Gordana Wozniak-Knopp

IPC: C40B40/08 ,  C07K19/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/40

CPC classification number: C40B40/08 ,  C07K19/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/40 ,  C07K2317/526 ,  C40B40/10

Abstract: Libraries of immunoglobulins which each have one or more amino acid modifications in at least one structural loop region of such immunoglobulins, where the modified loop region specifically binds to an epitope of an antigen to which an unmodified immunoglobulin does not significantly bind.

公开(公告)号：US20240150495A1

公开(公告)日：2024-05-09

申请号：US18521492

申请日：2023-11-28

Applicant: F-STAR THERAPEUTICS LIMITED

Inventor： Florian Ruker ,  Gottfried Himmler ,  Gordana Wozniak-Knopp

IPC: C07K16/46 ,  C07K16/00 ,  C07K16/28

CPC classification number: C07K16/468 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2887 ,  C07K2317/52

Abstract: The present invention provides a multivalent immunoglobulin or part thereof binding specifically to at least two cell surface molecules of a single cell with at least one modification in at least one structural loop region of the immunoglobulin determining binding to an epitope of the cell surface molecules wherein the unmodified immunoglobulin does not significantly bind to the epitope, its use and methods for producing it.

公开(公告)号：US11499249B2

公开(公告)日：2022-11-15

申请号：US16692220

申请日：2019-11-22

Applicant: F-star Therapeutics Limited

Inventor： Gottfried Himmler ,  Florian Ruker ,  Gordana Wozniak-Knopp

IPC: C40B40/08 ,  C07K19/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/40 ,  C40B40/10

Abstract: Libraries of immunoglobulins which each have one or more amino acid modifications in at least one structural loop region of such immunoglobulins, where the modified loop region specifically binds to an epitope of an antigen to which an unmodified immunoglobulin does not significantly bind.