公开(公告)号：US12187798B2

公开(公告)日：2025-01-07

申请号：US17534315

申请日：2021-11-23

Applicant: F-star Therapeutics Limited

Inventor： Mihriban Tuna ,  Francisca Wollerton van Horck ,  Katy Louise Everett ,  Miguel Gaspar ,  Matthew Kraman ,  Katarzyna Kmiecik ,  Natalie Fosh

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/00

Abstract: The present invention relates to specific binding members which bind to lymphocyte-activation gene 3 (LAG-3). The specific binding members preferably comprise a LAG-3 antigen-binding site which may be located in two or more structural loops of a CH3 domain of the specific binding member. The specific binding members of the invention find application, for example, in cancer therapy.

公开(公告)号：US20240376215A1

公开(公告)日：2024-11-14

申请号：US18652676

申请日：2024-05-01

Applicant: GammaDelta Therapeutics Ltd ,  F-star Therapeutics Limited

Inventor： Mihriban Tuna ,  Mark Uden ,  Joshua Freedman ,  Natalie Mount

IPC: C07K16/28

Abstract: The present invention provides multispecific antibodies comprising a Fab region and an Fc region, wherein the Fab region comprises a binding site specific for an epitope of the variable delta 1 (Vδ1) chain of a γδ T cell receptor (TCR); and the Fc region comprises an EGFR binding site. The present invention also provides compositions and pharmaceutical compositions comprising such multispecific antibodies, and method of making such multispecific antibodies. The present invention also provides methods of treatment and medical uses involving the multispecific antibodies.

公开(公告)号：US11827720B2

公开(公告)日：2023-11-28

申请号：US15677667

申请日：2017-08-15

Applicant: F-star Therapeutics Limited

Inventor： Florian Ruker ,  Gottfried Himmler ,  Gordana Wozniak-Knopp

IPC: C07K16/00 ,  C07K16/46 ,  C07K16/28

CPC classification number: C07K16/468 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2887 ,  C07K2317/52

Abstract: The present invention provides a multivalent immunoglobulin or part thereof binding specifically to at least two cell surface molecules of a single cell with at least one modification in at least one structural loop region of the immunoglobulin determining binding to an epitope of the cell surface molecules wherein the unmodified immunoglobulin does not significantly bind to the epitope, its use and methods for producing it.

公开(公告)号：US12103976B2

公开(公告)日：2024-10-01

申请号：US17259754

申请日：2019-07-12

Applicant: F-star Therapeutics Limited

Inventor： Matthew Lakins ,  Jose Munoz-Olaya ,  Sarka Pechouckova ,  Mihriban Tuna

IPC: C07K16/00 ,  A61P35/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/71

Abstract: The invention relates to specific binding members that bind CD137. The specific binding members comprise a CD137 antigen-binding site located in a constant domain of the specific binding member and find application in the treatment of cancer and infectious diseases, for example.

公开(公告)号：US20230357413A1

公开(公告)日：2023-11-09

申请号：US18166202

申请日：2023-02-08

Applicant: F-STAR THERAPEUTICS LIMITED

Inventor： Mihriban Tuna ,  Kin-Mei Leung ,  Haijun Sun ,  Melanie Medcalf ,  Samine Isaac

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/22 ,  A61K31/517 ,  A61K47/68 ,  A61P11/00 ,  A61P35/00 ,  C07K16/46

CPC classification number: C07K16/2863 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/22 ,  A61K31/517 ,  A61K47/6845 ,  A61K47/6813 ,  A61P11/00 ,  A61P35/00 ,  C07K16/468 ,  A61K2039/505

Abstract: The application relates to specific binding members which bind the human epidermal growth factor receptor (EGFR). The specific binding members preferably comprise an EGFR antigen-binding site which may be located in two or more structural loops of a CH3 domain of the specific binding member. The specific binding members are expected to find application in the treatment of cancers expressing EGFR.

公开(公告)号：US20230406935A1

公开(公告)日：2023-12-21

申请号：US18063521

申请日：2022-12-08

Applicant: F-star Therapeutics Limited

Inventor： Mihriban Tuna ,  Francisca Wollerton Van Horck ,  Ryan Fiehler ,  Mustapha Faroudi ,  Frederick Akele ,  Fadi Badr ,  Cyril Privezentzev

IPC: C07K16/28

CPC classification number: C07K16/2827 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/76 ,  C07K2317/92

Abstract: The application relates to specific binding members which bind to programmed death-ligand 1 (PD-L1). The specific binding members preferably comprise a PD-L1 antigen-binding site located in structural loops of a constant domain of the specific binding member. The specific binding members find application, for example, in the treatment of cancer, as well as infectious diseases, inflammation, diseases and conditions associated with inflammation, and inflammatory diseases.

公开(公告)号：US20230340696A1

公开(公告)日：2023-10-26

申请号：US17963509

申请日：2022-10-11

Applicant: F-STAR THERAPEUTICS LIMITED

Inventor： Gottfried Himmler ,  Florian Ruker ,  Gordana Wozniak-Knopp

IPC: C40B40/08 ,  C07K19/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/40

CPC classification number: C40B40/08 ,  C07K19/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/40 ,  C07K2317/526 ,  C40B40/10

Abstract: Libraries of immunoglobulins which each have one or more amino acid modifications in at least one structural loop region of such immunoglobulins, where the modified loop region specifically binds to an epitope of an antigen to which an unmodified immunoglobulin does not significantly bind.

公开(公告)号：US20220185890A1

公开(公告)日：2022-06-16

申请号：US17534315

申请日：2021-11-23

Applicant: F-star Therapeutics Limited

Inventor： Mihriban Tuna ,  Francisca Wollerton ,  Katy Everett ,  Miguel Gaspar ,  Matthew Kraman ,  Katarzyna Kmiecik ,  Natalie Fosh

IPC: C07K16/28 ,  A61P35/00

Abstract: The present invention relates to specific binding members which bind to lymphocyte-activation gene 3 (LAG-3). The specific binding members preferably comprise a LAG-3 antigen-binding site which may be located in two or more structural loops of a CH3 domain of the specific binding member. The specific binding members of the invention find application, for example, in cancer therapy.

公开(公告)号：US20240150495A1

公开(公告)日：2024-05-09

申请号：US18521492

申请日：2023-11-28

Applicant: F-STAR THERAPEUTICS LIMITED

Inventor： Florian Ruker ,  Gottfried Himmler ,  Gordana Wozniak-Knopp

IPC: C07K16/46 ,  C07K16/00 ,  C07K16/28

CPC classification number: C07K16/468 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2887 ,  C07K2317/52

Abstract: The present invention provides a multivalent immunoglobulin or part thereof binding specifically to at least two cell surface molecules of a single cell with at least one modification in at least one structural loop region of the immunoglobulin determining binding to an epitope of the cell surface molecules wherein the unmodified immunoglobulin does not significantly bind to the epitope, its use and methods for producing it.

公开(公告)号：US20240132599A1

公开(公告)日：2024-04-25

申请号：US18451047

申请日：2023-08-16

Applicant: GammaDelta Therapeutics Ltd ,  F-Star Therapeutics Limited

Inventor： Mihriban Tuna ,  Mark Uden ,  Joshua Freedman ,  Natalie Mount

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  C07K16/2809 ,  C07K2317/31

Abstract: The present invention provides multispecific antibodies comprising a Fab region and an Fc region, wherein the Fab region comprises a binding site specific for an epitope of the variable delta 1 (Vδ1) chain of a γδ T cell receptor (TCR); and the Fe region comprises an EGFR binding site. The present invention also provides compositions and pharmaceutical compositions comprising such multispecific antibodies, and method of making such multispecific antibodies. The present invention also provides methods of treatment and medical uses involving the multispecific antibodies.