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公开(公告)号：US20160331878A1
公开(公告)日：2016-11-17
申请号：US15110520
申请日：2015-01-15
Applicant: ENDOCELLUTIONS, INC.
Inventor： Andrew McGillicuddy , Andy H. Levine
CPC classification number: A61M1/0086 , A61B10/025 , A61B2010/0258 , A61B2017/3443 , A61B2090/034 , A61M1/0084 , A61M2205/586
Abstract: A bone marrow aspiration device and associated method includes an introducer needle assembly and an aspiration needle assembly. The introducer needle assembly includes an introducer cannula having proximal and distal ends, each end including an opening, and a screw assembly coupled to the introducer handle. The screw assembly includes a threaded tube and a lead screw receivable in the threaded tube. An outer cover is disposed around and in sealing engagement with the threaded tube and the lead screw. The aspiration needle assembly is receivable in the introducer cannula and includes an aspiration cannula forming a channel for aspirating bone marrow and including a flexible portion that extends from a distal end along a length of the aspiration cannula. A length of the aspiration cannula that extends beyond the distal end of the introducer cannula is adjustable by advancing the lead screw into or reversing the lead screw out of the threaded tube.
Abstract translation: 骨髓抽吸装置和相关方法包括导引针组件和抽吸针组件。 引导器针组件包括具有近端和远端的导引器插管，每个端部包括开口，以及联接到导引器手柄的螺钉组件。 螺杆组件包括螺纹管和可接收在螺纹管中的丝杠。 外盖设置在螺纹管和丝杠的周围并与其密封接合。 抽吸针组件可接纳在导引套管中，并且包括形成用于吸入骨髓的通道的抽吸插管并且包括从远端沿着吸液套管的长度延伸的柔性部分。 延伸超过导引套管远端的抽吸套管的长度可通过将导螺杆推进螺纹管或从螺旋管中反转来调节。
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公开(公告)号：US10568661B2
公开(公告)日：2020-02-25
申请号：US15721123
申请日：2017-09-29
Applicant: EndoCellutions, Inc.
Inventor： Andrew McGillicuddy
Abstract: A bone marrow access device includes a cannula and a sharp stylet removably positioned in the cannula. The cannula defines a distal opening at a distal tip and a side aperture in a side of the cannula, proximally from the distal opening. The stylet has a sharp distal tip and extends beyond the distal opening. A plug is receivable in the cannula distal to the side aperture to seal the distal opening when the stylet is removed. A method of accessing bone includes inserting the cannula and sharp stylet positioned in the cannula into bone; removing the sharp stylet from the cannula; pushing a plug through the cannula and distal to the side aperture to seal the distal opening of the cannula; and accessing the bone through the side aperture. Accessing the bone can include aspirating bone marrow, injecting a substance, or inserting an instrument into the bone.
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公开(公告)号：US10231716B2
公开(公告)日：2019-03-19
申请号：US14439022
申请日：2013-10-29
Applicant: EndoCellutions, Inc.
Inventor： Andrew McGillicuddy , Andy H. Levine , Neil F. Duffy, Jr.
Abstract: A bone marrow aspiration device and associated method includes an introducer needle and an aspiration needle. The introducer needle includes an introducer cannula and a removable introducer stylet that includes a sharp tip to penetrate bone. The aspiration needle includes an optionally flexible aspiration cannula and a blunt stylet. The aspiration needle is receivable in the introducer cannula when the introducer stylet is removed from the introducer needle. The aspiration cannula forms a channel for aspirating bone marrow when the stylet is removed. The aspiration device also includes a locking mechanism to lock the aspiration cannula to the introducer cannula when the aspiration cannula is received in the introducer cannula, whereby the aspiration cannula can be advanced distally relative to the introducer cannula in a controlled manner, and whereby pulling the aspiration cannula proximally causes the introducer cannula to move proximally with the aspiration cannula.
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公开(公告)号：US09763877B2
公开(公告)日：2017-09-19
申请号：US14822065
申请日：2015-08-10
Applicant: EndoCellutions, Inc.
Inventor： Neil F. Duffy, Jr. , Andrew McGillicuddy
IPC: A61K9/00 , A61K35/35 , A61K35/50 , A61K35/51 , A61K35/28 , A61K35/12 , C12N5/077 , C12N5/0775 , C12N5/07 , C12N5/074
CPC classification number: A61K9/0053 , A61K9/0019 , A61K35/12 , A61K35/28 , A61K35/35 , A61K35/50 , A61K35/51 , C12N5/06 , C12N5/0607 , C12N5/0653 , C12N5/0663 , C12N5/0667 , Y10S514/866
Abstract: The anatomic and functional arrangement of the gastrointestinal tract suggests an important function of this organ is its ability to regulate the trafficking of metabolites as well as control the equilibrium between tolerance and immunity through gut-associated lymphoid tissue, the neuroendocrine network, and the intestinal epithelial barrier. Combining nucleated cells from various tissues and introducing them directly into the small intestine will have a positive effect on diabetes.
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公开(公告)号：US20200305930A1
公开(公告)日：2020-10-01
申请号：US16729095
申请日：2019-12-27
Applicant: EndoCellutions, Inc.
Inventor： Andrew McGillicuddy
Abstract: A bone marrow access device includes a cannula and a sharp stylet removably positioned in the cannula. The cannula defines a distal opening at a distal tip and a side aperture in a side of the cannula, proximally from the distal opening. The stylet has a sharp distal tip and extends beyond the distal opening. A plug is receivable in the cannula distal to the side aperture to seal the distal opening when the stylet is removed. A method of accessing bone includes inserting the cannula and sharp stylet positioned in the cannula into bone; removing the sharp stylet from the cannula; pushing a plug through the cannula and distal to the side aperture to seal the distal opening of the cannula; and accessing the bone through the side aperture. Accessing the bone can include aspirating bone marrow, injecting a substance, or inserting an instrument into the bone.
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Patent Agency Ranking
公开(公告)号：US10603665B2
公开(公告)日：2020-03-31
申请号：US14764115
申请日：2014-01-29
Applicant: EndoCellutions, Inc.
Inventor： Andy H. Levine , John C. Meade , Neil Tischler , Jeffrey R. Chabot , Andrew McGillicuddy , Neil F. Duffy, Jr.
Abstract: A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a container defining a cavity for receiving the fluid. The container has a top, a sidewall extending from the top, and a bottom disposed opposite the top and in sealing engagement with the sidewall. An insert is slidably disposed in the cavity of the container and defines a lumen through the insert. The lumen, which includes a hole and a funnel-shaped upper portion in fluid communication with the hole, forms an open fluid path between opposite ends of the insert. The insert has a density such that upon centrifugation a selected component of the fluid resides within the lumen. A container port is disposed in the top of the container to transfer the fluid into the container and to withdraw a fluid component other than the selected component from the container. The system includes a manifold that includes a manifold port, a vent to vent the container, and a connector to couple to the container port. A cannula is receivable in the manifold port and extendable through the container port into the container and into the lumen of the insert to withdraw the selected component from the lumen.
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公开(公告)号：US20160008808A1
公开(公告)日：2016-01-14
申请号：US14764115
申请日：2014-01-29
Applicant: ENDOCELLUTIONS, INC.
Inventor： Andy H. Levine , John C. Meade , Neil Tischler , Jeffrey R. Chabot , Andrew McGillicuddy , Neil F. Duffy, JR.
CPC classification number: B01L3/5082 , A61M1/029 , A61M1/3693 , B01D21/262 , B01L3/0282 , B01L3/50215 , B01L2200/026 , B01L2200/0684 , B01L2200/0689 , B01L2300/046 , B01L2300/0858 , B01L2400/0409 , B01L2400/0478
Abstract: A system and associated method for concentrating and separating components of different densities from fluid containing cells using a centrifuge includes a container defining a cavity for receiving the fluid. The container has a top, a sidewall extending from the top, and a bottom disposed opposite the top and in sealing engagement with the sidewall. An insert is slidably disposed in the cavity of the container and defines a lumen through the insert. The lumen, which includes a hole and a funnel-shaped upper portion in fluid communication with the hole, forms an open fluid path between opposite ends of the insert. The insert has a density such that upon centrifugation a selected component of the fluid resides within the lumen. A container port is disposed in the top of the container to transfer the fluid into the container and to withdraw a fluid component other than the selected component from the container. The system includes a manifold that includes a manifold port, a vent to vent the container, and a connector to couple to the container port. A cannula is receivable in the manifold port and extendable through the container port into the container and into the lumen of the insert to withdraw the selected component from the lumen.
Abstract translation: 使用离心机将不同密度的组分与含有流体的细胞集中和分离的系统和相关方法包括限定用于接收流体的空腔的容器。 容器具有顶部，从顶部延伸的侧壁和与顶部相对设置并与侧壁密封接合的底部。 插入件可滑动地设置在容器的空腔中并且通过插入件限定内腔。 包括孔和与孔流体连通的漏斗形上部的内腔在插入物的相对端之间形成开放的流体路径。 插入物具有这样的密度，使得在离心时，选定的流体成分位于内腔内。 容器端口设置在容器的顶部以将流体转移到容器中并且从容器中抽出除了所选择的部件之外的流体部件。 该系统包括歧管，其包括歧管端口，用于排出容器的通风口以及连接到容器端口的连接器。 套管可接收在歧管端口中并且可以通过容器端口延伸到容器中并进入插入件的内腔，以从管腔中抽出所选择的部件。
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公开(公告)号：US20220072330A1
公开(公告)日：2022-03-10
申请号：US17414740
申请日：2019-12-18
Applicant: EndoCellutions, Inc. , IPG Photonics Corporation
Inventor： Andrew McGillicuddy , Ilya Yaroslavsky , Emil Sobol , Andrey Baskov
Abstract: A device and associated method for treatment of tissue in a joint of a mammal includes an energy source and an energy-delivery implement coupled to the energy source. The energy-delivery implement has a distal portion configured to be inserted into the joint, the distal portion having at least one energy-emitting portion. A control module causes the energy source to produce energy in a pre-defined treatment sequence, the sequence comprising at least two pulses of energy separated by an interval. The energy-delivery implement is configured to emit the energy at the distal portion, to create a zone of thermal stress within target tissue, without causing substantial coagulation of the target tissue, wherein the size of the thermal stress zone is substantially less than the size of the target tissue being treated. A biologic can be injected or otherwise delivered into the joint before, during, or after delivery of the energy.
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公开(公告)号：US20210038201A1
公开(公告)日：2021-02-11
申请号：US17080999
申请日：2020-10-27
Applicant: EndoCellutions, Inc.
Inventor： Andrew McGillicuddy
IPC: A61B10/02
Abstract: A bone marrow aspiration device and related method includes an introducer assembly and an aspiration assembly to couple to the introducer assembly. The introducer assembly includes an introducer cannula having a proximal end and a distal end. The introducer cannula defines a lumen between the distal and proximal ends, the distal end being configured to penetrate bone of a patient. The aspiration assembly includes an aspiration cannula that is receivable in the lumen of the introducer cannula and that extends beyond the distal end of the introducer cannula. The aspiration cannula includes a port to aspirate bone marrow, the port being distal to the distal end of the introducer cannula. The aspiration device further includes a mechanism at the introducer assembly to move the introducer cannula and the aspiration cannula in tandem relative to a distal end of the mechanism when the aspiration cannula is positioned within bone.
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公开(公告)号：US10556046B2
公开(公告)日：2020-02-11
申请号：US15110520
申请日：2015-01-15
Applicant: EndoCellutions, Inc.
Inventor： Andrew McGillicuddy , Andy H. Levine
Abstract: A bone marrow aspiration device and associated method includes an introducer needle assembly and an aspiration needle assembly. The introducer needle assembly includes an introducer cannula having proximal and distal ends, each end including an opening, and a screw assembly coupled to the introducer handle. The screw assembly includes a threaded tube and a lead screw receivable in the threaded tube. An outer cover is disposed around and in sealing engagement with the threaded tube and the lead screw. The aspiration needle assembly is receivable in the introducer cannula and includes an aspiration cannula forming a channel for aspirating bone marrow and including a flexible portion that extends from a distal end along a length of the aspiration cannula. A length of the aspiration cannula that extends beyond the distal end of the introducer cannula is adjustable by advancing the lead screw into or reversing the lead screw out of the threaded tube.
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