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    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
    1.
    发明申请
    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开

    公开(公告)号：US20060293383A1

    公开(公告)日：2006-12-28

    申请号：US11194875

    申请日：2006-03-30

    申请人： Ellen Codd ,  Carlos Plata-Salaman ,  Boyu Zhao

    发明人： Ellen Codd ,  Carlos Plata-Salaman ,  Boyu Zhao

    IPC分类号： A61K31/325

    CPC分类号： A61K31/325 ,  A61K31/27

    摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of Formula (I) substantially free of other enantiomers or an enantiomeric mixture wherein an enantiomer of Formula (I) predominates: wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1 and R2 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
    2.
    发明申请
    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开
    用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物

    公开(公告)号：US20050009905A1

    公开(公告)日：2005-01-13

    申请号：US10870103

    申请日：2004-06-17

    申请人： Ellen Codd ,  Carlos Plata-Salaman ,  Boyu Zhao

    发明人： Ellen Codd ,  Carlos Plata-Salaman ,  Boyu Zhao

    IPC分类号： A61P25/04 ,  A61K31/27 ,  A61K31/325

    CPC分类号： A61K31/325 ,  A61K31/27

    摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of Formula (I) substantially free of other enantiomers or an enantiomeric mixture wherein an enantiomer of Formula (I) predominates: wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1 and R2 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

    摘要翻译： 本发明涉及一种用于预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的基本上不含其它对映异构体或对映体混合物的式（I）对映异构体 其中式（I）的对映异构体占主导地位：其中苯基在X上被一至五个独立地选自氟，氯，溴和碘的卤素原子取代; 和; R 1和R 2独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
    3.
    发明申请
    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开
    用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物

    公开(公告)号：US20050250847A1

    公开(公告)日：2005-11-10

    申请号：US11120278

    申请日：2005-02-24

    申请人： Ellen Codd ,  Carlos Plata-Salaman ,  Boyu Zhao

    发明人： Ellen Codd ,  Carlos Plata-Salaman ,  Boyu Zhao

    IPC分类号： A61P25/02 ,  A61K31/27 ,  A61P25/04 ,  A61P25/06 ,  A61K31/325

    CPC分类号： A61K31/27

    摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

    摘要翻译： 本发明涉及一种预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一个 至五个独立地选自氟，氯，溴和碘的卤素原子; 和; R 1，R 2，R 3和R 4各自独立地选自氢和C 1个C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1〜 C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。

    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
    4.
    发明申请
    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开
    用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物

    公开(公告)号：US20060183795A1

    公开(公告)日：2006-08-17

    申请号：US11194876

    申请日：2005-02-18

    申请人： Ellen Codd ,  Richard Shank ,  Katherine Rogers ,  Carlos Plata-Salaman ,  Boyu Zhao

    发明人： Ellen Codd ,  Richard Shank ,  Katherine Rogers ,  Carlos Plata-Salaman ,  Boyu Zhao

    IPC分类号： A61K31/325

    CPC分类号： A61K31/27

    摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of Formula (I) substantially free of other enantiomers or an enantiomeric mixture wherein an enantiomer of Formula (I) predominates: wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1 and R2 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

    摘要翻译： 本发明涉及一种用于预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的基本上不含其它对映异构体或对映体混合物的式（I）对映异构体 其中式（I）的对映异构体占主导地位：其中苯基在X上被一至五个独立地选自氟，氯，溴和碘的卤素原子取代; 和; R 1和R 2独立地选自氢和C 1 -C 4烷基; R 1，R 2和R 2独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1〜 C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。