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公开(公告)号：US10550148B2
公开(公告)日：2020-02-04
申请号：US14736596
申请日：2015-06-11
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Herbert Lutz , Bala Raghunath
IPC: C07K1/34 , C07K1/18 , C07K16/00 , C07K1/22 , B01D15/08 , B01D61/14 , C07K16/06 , C07K1/36 , B01D15/12 , A61L2/00
Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.
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公开(公告)号：US20190099716A1
公开(公告)日：2019-04-04
申请号：US16207874
申请日：2018-12-03
Applicant: EMD Millipore Corporation
Inventor： Herbert Lutz , Joseph Parrella , Bala Raghunath
IPC: B01D61/14
Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
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公开(公告)号：US20230211291A1
公开(公告)日：2023-07-06
申请号：US18183609
申请日：2023-03-14
Applicant: EMD Millipore Corporation
Inventor： Elizabeth M. Goodrich , Akshat Gupta , Herbert Lutz
CPC classification number: B01D61/146 , B01D61/18 , B01D61/22 , B01D65/02 , B01D2311/04 , B01D2311/08 , B01D2311/25 , B01D2313/18 , B01D2313/243 , B01D2313/50 , B01D2315/10 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2317/04 , B01D2321/16
Abstract: Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.
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公开(公告)号：US20190153027A1
公开(公告)日：2019-05-23
申请号：US16259489
申请日：2019-01-28
Applicant: EMD Millipore Corporation
Inventor： Venkatesh Natarajan , Herbert Lutz , Bala Raghunath
IPC: C07K1/18 , C07K16/00 , B01D15/08 , C07K1/22 , C07K1/36 , B01D61/14 , C07K16/06 , C07K1/34 , B01D15/12
Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.
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公开(公告)号：US10195550B2
公开(公告)日：2019-02-05
申请号：US14839779
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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Patent Agency Ranking
公开(公告)号：US12201925B2
公开(公告)日：2025-01-21
申请号：US17682221
申请日：2022-02-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US11679349B2
公开(公告)日：2023-06-20
申请号：US17315721
申请日：2021-05-10
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
CPC classification number: B01D29/908 , B01D29/52 , B01D29/603 , B01D61/145 , B01D61/146 , B01D61/147 , B01D63/082 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2315/10 , B01D2315/16 , B01D2319/022
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US20210355159A1
公开(公告)日：2021-11-18
申请号：US17311099
申请日：2019-11-11
Applicant: EMD Millipore Corporation
Inventor： Thomas Elich , Herbert Lutz
Abstract: Method and system for purifying a sample comprising a biomolecule of interest and impurities, comprising expressing said biomolecule of interest in a bioreactor to form a product sample comprising said biomolecule of interest and impurities; subjecting said product sample to single pass tangential flow filtration to form a concentrated product sample; and subjecting said concentrated product sample to affinity chromatography to remove impurities from said concentrated product sample.
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公开(公告)号：US20190282937A1
公开(公告)日：2019-09-19
申请号：US16427942
申请日：2019-05-31
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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10.发明申请公开(公告)号：US20160059159A1
公开(公告)日：2016-03-03
申请号：US14839779
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
CPC classification number: B01D29/908 , B01D29/52 , B01D29/603 , B01D61/142 , B01D61/145 , B01D61/147 , B01D63/082 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2315/10 , B01D2315/16 , B01D2319/022
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
Abstract translation: 描述了一种过滤液体进料的方法，包括使液体进料通过单程切向流过滤（SPTFF）系统，并在分离的容器中回收系统中的渗余物和渗透物。 还描述了过滤液体进料的方法，包括使液体进料通过切向流过滤（TFF）系统，在分离的容器中从系统中回收渗透物和一部分滞留物，而不通过TFF系统再循环，并将剩余物 的滞留物通过TFF系统至少一次。 本发明的方法可以使用包括歧管段的SPTFF或TFF系统来进行，以串行化进料和滞留物的流动路径，而不需要转向板。
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