公开(公告)号：US20150276651A1

公开(公告)日：2015-10-01

申请号：US14436211

申请日：2013-10-07

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： James R. Petisce ,  Alexander H. Gorham ,  David Zhou

IPC: G01N27/327 ,  C23F1/26 ,  C23F1/12 ,  C23F1/44

CPC classification number: G01N27/3271 ,  C12Q1/001 ,  C23F1/12 ,  C23F1/26 ,  C23F1/44 ,  G01N27/3272

Abstract: Methods for fabricating analyte sensor components using IC- or MEMs-based fabrication techniques and sensors prepared therefrom. Fabrication of the analyte sensor component comprises providing an inorganic substrate having deposited thereon a release layer, a first flexible dielectric layer and a second flexible dielectric layer insulating there between electrodes, contact pads and traces connecting the electrodes and the contact pads of a plurality of sensors. Openings are provided in one of the dielectric layers over one or more of the electrodes to receive an analyte sensing membrane for the detection of an analyte of interest and for electrical connection with external electronics. The plurality of fabricated sensor components are lifted off the inorganic substrate. Methods of improving sensor performance by solution based and non-solution based etching are provided.

Abstract translation: 使用基于IC或MEM的制造技术和由其制备的传感器来制造分析物传感器部件的方法。 分析物传感器部件的制造包括提供其上沉积有释放层的无机基材，在电极之间绝缘的第一柔性介电层和绝缘的第二柔性介电层，连接多个传感器的电极和接触焊盘的接触焊盘和迹线 。 在一个或多个电极中的一个电介质层中提供开口，以接收用于检测感兴趣分析物并与外部电子器件电连接的分析物感测膜。 将多个制造的传感器部件从无机基板上提起。 提供了通过基于溶液和非溶液的蚀刻来提高传感器性能的方法。

公开(公告)号：US20140209459A1

公开(公告)日：2014-07-31

申请号：US14229369

申请日：2014-03-28

Applicant: Edwards Lifesciences Corporation

Inventor： Henry W. Oviatt ,  James R. Petisce ,  Charles R. Mooney

IPC: G01N27/327

CPC classification number: G01N27/3271 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/415 ,  C12Q1/001 ,  C12Q1/002

Abstract: Electrochemical sensors for measurement of an analyte comprising an analyte sensing membrane comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof. Sensor testing methods comprising contacting an electrochemical sensor with an aqueous solution comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof and contacting the electrochemical sensor with one or more concentrations of analyte, the one or more concentrations of analyte being in the clinical concentration range of the analyte.

Abstract translation: 用于测量包括分析物感测膜的分析物传感膜的电化学传感器，其包含至少一种乙酸根离子，碳酸根离子，碳酸氢根离子或其混合物的盐。 传感器测试方法，包括使电化学传感器与包含至少一种乙酸根离子，碳酸根离子，碳酸氢根离子或其混合物的盐的水溶液接触，并使电化学传感器与一种或多种浓度的分析物接触，所述一种或多种分析物浓度 处于分析物的临床浓度范围。

公开(公告)号：US20140166612A1

公开(公告)日：2014-06-19

申请号：US14185627

申请日：2014-02-20

Applicant: Edwards Lifesciences Corporation

Inventor： James R. Petisce ,  David Zhou ,  Mena Valiket

IPC: G01N27/327 ,  B81C1/00

CPC classification number: G01N27/3272 ,  A61B5/0006 ,  A61B5/415 ,  A61B2562/028 ,  A61B2562/043 ,  A61B2562/12 ,  A61B2562/125 ,  B32B37/025 ,  B32B2309/105 ,  B32B2311/02 ,  B32B2457/00 ,  B32B2535/00 ,  B81C1/00539

Abstract: Methods for fabricating analyte sensor components using IC- or MEMs-based fabrication techniques and sensors prepared therefrom. Fabrication of the analyte sensor component comprises providing an inorganic substrate having deposited thereon a release layer, a first flexible dielectric layer and a second flexible dielectric layer insulating there between electrodes, contact pads and traces connecting the electrodes and the contact pads of a plurality of sensors. Openings are provided in one of the dielectric layers over one or more of the electrodes to receive an analyte sensing membrane for the detection of an analyte of interest and for electrical connection with external electronics. The plurality of fabricated sensor components are lifted off the inorganic substrate.

Abstract translation: 使用基于IC或MEM的制造技术和由其制备的传感器来制造分析物传感器部件的方法。 分析物传感器部件的制造包括提供其上沉积有释放层的无机基材，在电极之间绝缘的第一柔性介电层和绝缘的第二柔性介电层，连接多个传感器的电极和接触焊盘的接触焊盘和迹线 。 在一个或多个电极中的一个电介质层中提供开口，以接收用于检测感兴趣分析物并与外部电子器件电连接的分析物感测膜。 将多个制造的传感器部件从无机基板上提起。

公开(公告)号：US20130228002A1

公开(公告)日：2013-09-05

申请号：US13864936

申请日：2013-04-17

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： James R. Petisce ,  Michael Higgins ,  Kristie P. Trinh ,  Todd Abraham

IPC: G01N33/96

CPC classification number: G01N33/96 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/4839 ,  A61M2207/00 ,  A61M2230/201 ,  Y10T436/10 ,  Y10T436/102499 ,  Y10T436/104998 ,  Y10T436/108331

Abstract: Methods and systems for preparation of calibrant infusion fluid sources are disclosed. In one embodiment, a precise volume of glucose is injected into a saline-solution filled calibrant infusion fluid source proximate in time to conducting a calibration procedure. The glucose concentration in the calibrant infusion fluid source is subsequently calculated based on the measured weight of the saline-solution, as determined prior to glucose injection, and the volume of glucose injected. This method provides a highly accurate and convenient manner for use in a hospital environment, for example, with an intravenous blood glucose sensor system. In another embodiment, a premixed calibrant infusion fluid source is provided that includes saline solution and a predetermined concentration of glucose. In such embodiments, shelf life problems related to water evaporation are mitigated by hermetically covering or otherwise hermetically containing the calibrant infusion fluid source up until the point of use.

Abstract translation: 公开了用于制备校准液输注液源的方法和系统。 在一个实施方案中，在时间上将精确体积的葡萄糖注入盐水溶液填充的校准液输注液源中以进行校准程序。 随后根据在注射葡萄糖之前测定的盐水溶液的测量重量和注入的葡萄糖体积来计算校准液输注液源中的葡萄糖浓度。 该方法提供了在医院环境中使用的高度准确和方便的方式，例如使用静脉内血糖传感器系统。 在另一个实施方案中，提供了预混合的校准液输注液源，其包括盐溶液和预定浓度的葡萄糖。 在这样的实施方案中，通过气密地覆盖或以其他方式密封含有校准液输注流体源直到使用点来减轻与水蒸发相关的保质期问题。